SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Sigurdsson E) "

Sökning: WFRF:(Sigurdsson E)

  • Resultat 61-70 av 155
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
61.
  •  
62.
  • Majewski, S., et al. (författare)
  • The impact of a quadrivalent human papillomavirus (types 6, 11, 16, 18) virus-like particle vaccine in European women aged 16 to 24
  • 2009
  • Ingår i: Journal of the European Academy of Dermatology and Venereology. - : Wiley. - 1468-3083 .- 0926-9959. ; 23:10, s. 1147-1155
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Quadrivalent human papillomavirus (HPV types 6/11/16/18) L1 VLP vaccine is highly effective in preventing HPV 6/11/16/18-related cervical and external genital disease. Herein, we evaluated the impact of the quadrivalent HPV 6/11/16/18 L1 VLP vaccine on prevention of HPV-associated cervico-genital lesions in a broad population of sexually active European women. Methods Female subjects (N = 9265) aged 16-24 with four or fewer lifetime sexual partners were enrolled and randomized to quadrivalent HPV vaccine or placebo. Subjects underwent cervicovaginal sampling for HPV DNA detection. Papanicolaou testing and anti-HPV 6/11/16/18 serology testing was also performed. Results Vaccine efficacy against lesions representing immediate cervical cancer precursors (cervical intraepithelial neoplasia grade 2/3 or adenocarcinoma in situ) related to HPV 6/11/16/18 in the per-protocol population was 100.0%[95% confidence interval (95% CI), 89.8-100.0]. Efficacy against external genital lesions (vulvar or vaginal intraepithelial neoplasia, condyloma, vulvar or vaginal cancer) related to vaccine HPV types in the per-protocol European population was 99.0% (95% CI, 94.4-100.0). Conclusion These data demonstrate that quadrivalent HPV 6/11/16/18 vaccination programs in 16- to 24-year-old European women can be beneficial. NCT0009252, NCT00092534, NCT00092495.
  •  
63.
  • Palmer, Nicholette D, et al. (författare)
  • A genome-wide association search for type 2 diabetes genes in African Americans.
  • 2012
  • Ingår i: PloS one. - San Francisco : Public Library of Science (PLoS). - 1932-6203. ; 7:1, s. e29202-
  • Tidskriftsartikel (refereegranskat)abstract
    • African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n = 550 independent loci) were genotyped in a replication cohort and 122 SNPs (n = 98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P<0.0071), were directionally consistent in the Replication cohort and were associated with T2DM in subjects without nephropathy (P<0.05). Meta-analysis in all cases and controls revealed a single SNP reaching genome-wide significance (P<2.5×10(-8)). SNP rs7560163 (P = 7.0×10(-9), OR (95% CI) = 0.75 (0.67-0.84)) is located intergenically between RND3 and RBM43. Four additional loci (rs7542900, rs4659485, rs2722769 and rs7107217) were associated with T2DM (P<0.05) and reached more nominal levels of significance (P<2.5×10(-5)) in the overall analysis and may represent novel loci that contribute to T2DM. We have identified novel T2DM-susceptibility variants in the African-American population. Notably, T2DM risk was associated with the major allele and implies an interesting genetic architecture in this population. These results suggest that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
  •  
64.
  •  
65.
  •  
66.
  •  
67.
  •  
68.
  •  
69.
  •  
70.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 61-70 av 155
Typ av publikation
tidskriftsartikel (143)
konferensbidrag (9)
annan publikation (1)
forskningsöversikt (1)
bokkapitel (1)
Typ av innehåll
refereegranskat (140)
övrigt vetenskapligt/konstnärligt (15)
Författare/redaktör
Stefansson, K (57)
Stefansson, H. (40)
Rietschel, M (33)
Steinberg, S (31)
Mors, O (30)
Werge, T (29)
visa fler...
Mattheisen, M (29)
Cichon, S (29)
Mortensen, PB (27)
Nothen, MM (27)
Borglum, AD (27)
Breen, G (26)
Ripke, S (26)
Craddock, N (25)
Hougaard, DM (25)
Nordentoft, M (25)
Esko, T (25)
Metspalu, A (25)
O'Donovan, MC (25)
Sullivan, PF (24)
Thorsteinsdottir, U (24)
Djurovic, S (23)
Muller-Myhsok, B (23)
Wray, NR (23)
Degenhardt, F (23)
Agerbo, E (22)
Herms, S. (22)
Frank, J (22)
Gill, M. (22)
Andreassen, OA (21)
Rujescu, D (21)
Hoffmann, P (21)
McIntosh, AM (21)
Smoller, JW (21)
Martin, NG (21)
Schulze, TG (21)
Grove, J (21)
Sigurdsson, G (21)
Bybjerg-Grauholm, J. (21)
Escott-Price, V (21)
Levinson, DF (20)
Strohmaier, J (20)
Melle, I (19)
Gudnason, V (19)
Montgomery, GW (19)
Lucae, S (19)
Shi, JX (19)
Knowles, JA (19)
Witt, SH (19)
Kendler, KS (19)
visa färre...
Lärosäte
Karolinska Institutet (101)
Lunds universitet (39)
Göteborgs universitet (32)
Uppsala universitet (29)
Umeå universitet (21)
Stockholms universitet (10)
visa fler...
Sveriges Lantbruksuniversitet (4)
Linköpings universitet (2)
Handelshögskolan i Stockholm (2)
Mittuniversitetet (2)
Chalmers tekniska högskola (2)
Mälardalens universitet (1)
Örebro universitet (1)
RISE (1)
visa färre...
Språk
Engelska (155)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (79)
Naturvetenskap (17)
Lantbruksvetenskap (4)
Teknik (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy