| 41. |
- Albåge, Anders, et al.
(författare)
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Long-Term Risk of Ischemic Stroke After the Cox-Maze III Procedure for Atrial Fibrillation
- 2017
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Ingår i: Annals of Thoracic Surgery. - : Elsevier BV. - 0003-4975 .- 1552-6259. ; 104:2, s. 523-529
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Tidskriftsartikel (refereegranskat)abstract
- Background The long-term risk of stroke after surgical treatment of atrial fibrillation is not well known. We performed an observational cohort study with long follow-up after the “cut-and-sew” Cox-maze III procedure (CM-III), including left atrial appendage excision. The aim was to analyze the incidence of stroke/transient ischemic attack (TIA) and the association to preoperative CHA2DS2-VASc (age in years, sex, congestive heart failure history, hypertension history, stroke/TIA, thromboembolism history, vascular disease history, diabetes mellitus) score. Methods Preoperative and perioperative data were collected in 526 CM-III patients operated in four centers 1994 to 2009, 412 men, mean age of 57.1 ± 8.3 years. The incidence of any stroke/TIA was identified through analyses of the Swedish National Patient and Cause-of-Death Registers and from review of individual patient records. The cumulative incidence of stroke/TIA and association with CHA2DS2-VASc score was estimated using methods accounting for the competing risk of death. Results Mean follow-up was 10.1 years. There were 29 patients with any stroke/TIA, including 6 with intracerebral bleedings (2 fatal) and 4 with perioperative strokes (0.76%). The remaining 13 ischemic strokes and six TIAs occurred at a mean of 7.1 ± 4.0 years postoperatively, with an incidence of 0.36% per year (19 events per 5,231 patient-years). In all CHA2DS2-VASc groups, observed ischemic stroke/TIA rate was lower than predicted. A higher risk of ischemic stroke/TIA was seen in patients with CHA2DS2-VASc score 2 or greater compared with score 0 or 1 (hazards ratio 2.15, 95% confidence interval: 0.87 to 5.32) but no difference by sex or stand-alone versus concomitant operation. No patient had ischemic stroke as cause of death. Conclusions This multicenter study showed a low incidence of perioperative and long-term postoperative ischemic stroke/TIA after CM-III. Although general risk of ischemic stroke/TIA was reduced, patients with CHA2DS2-VASc score 2 or greater had a higher risk compared with score 0 or 1. Complete left atrial appendage excision may be an important reason for the low ischemic stroke rate.
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| 42. |
- Andell, Pontus, et al.
(författare)
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Outcome of patients with chronic obstructive pulmonary disease and severe coronary artery disease who had a coronary artery bypass graft or a percutaneous coronary intervention
- 2017
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Ingår i: European Journal of Cardio-Thoracic Surgery. - : Oxford University Press (OUP). - 1010-7940 .- 1873-734X. ; 52:5, s. 930-936
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Patients with chronic obstructive pulmonary disease (COPD) who also have acute coronary syndromes are a high-risk population with a high mortality rate. Little is known about these patients following coronary artery bypass grafting (CABG). METHODS: Patients presenting with acute coronary syndromes between 2006 and 2014 with an angiogram showing 3-vessel disease or left main coronary artery involvement who were treated with CABG or percutaneous coronary intervention (PCI) only were included from the nationwide SWEDEHEART registry. Patients were stratified according to COPD status and compared with regard to outcome. The primary end-point was the 5-year mortality rate; secondary outcomes were the 30-day mortality rate and in-hospital complications after CABG. RESULTS: We identified 6985 patients in the population who had CABG (COPD prevalence = 8.0%) and 14 209 who had PCI only (COPD = 8.2%). Patients with COPD were older and had more comorbidities than patients without COPD. The 5-year mortality rate was nearly doubled in patients with COPD versus patients without COPD (CABG: 27.2% vs 14.5%, P < 0.001; PCI only: 50.1% vs 29.1%, P < 0.001). After adjusting for age, sex and comorbidities, patients with COPD in both CABG-treated [hazard ratio = 1.52 (1.25-1.86), P < 0.001] and PCI-treated populations still had a significantly higher 5-year mortality rate. COPD was also independently associated with significantly more postoperative infections in need of antibiotics [odds ratio = 1.48 (1.07-2.04), P = 0.017] and pneumonia [odds ratio = 2.21 (1.39-3.52), P = 0.001]. CONCLUSIONS: Patients with COPD presenting with acute coronary syndromes and severe coronary artery disease are a high-risk population following CABG or PCI only, with higher risk of long-term and short-term death and postoperative infections. Preventive measures, including careful monitoring for signs of infection and prompt antibiotic treatment when indicated, should be considered.
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| 43. |
- Antonsson, Ann-Beth, 1956-, et al.
(författare)
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Fatal Carbon Monoxide Intoxication After AcetyleneGas Welding of Pipes
- 2013
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Ingår i: Annals of Occupational Hygiene. - : Oxford University Press. - 0003-4878 .- 1475-3162. ; 57:5, s. 662-666
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Tidskriftsartikel (refereegranskat)abstract
- Acetylene gas welding of district heating pipes can result in exposure to high concentrations of carbon monoxide. A fatal case due to intoxication is described. Measurements of carbon monoxide revealed high levels when gas welding a pipe with closed ends. This fatality and these measurements highlight a new hazard, which must be promptly prevented.
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| 44. |
- Arvidsson, Björn, et al.
(författare)
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Online capillary solid phase extraction and liquid chromatographic separation with quantitative tandem mass spectrometric detection (SPE-LC-MS/MS) of ximelagatran and its metabolites in a complex matrix.
- 2009
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Ingår i: Journal of chromatography. B. - : Elsevier BV. - 1570-0232 .- 1873-376X. ; 877:3, s. 291-297
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Tidskriftsartikel (refereegranskat)abstract
- This work presents the development and validation of a fully automated quantitative analysis method of melagatran, its prodrug ximelagatran, and its major metabolites for the study of drug behavior in biofluids. The method involves online sample clean-up and enrichment on a C4 capillary column followed by separation on a capillary C18 column. Electrospray ionization tandem mass spectrometric detection in positive ion mode was performed with multiple reactions monitoring of eight different transients, divided into two time segments with four transients each. The structural similarity, the complexity of the matrix (pig liver extract) and the formation of isobaric fragment ions, made efficient chromatographic separation necessary. The analysis method provides valid accuracy (<9%; RSD%), precision (<8%; RSD%), linearity (<1.2 nM–1 μM; R2 > 0.999), limit of quantitation (<3.6 nM), retention repeatability (<1.2%; RSD%), selectivity, as well as analyte and column stabilities over a wide concentration range.
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| 45. |
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| 46. |
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| 47. |
- Benbow, Emma, et al.
(författare)
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Toolbox, review of functional triggers : Selection of maintenance candidates
- 2013
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- ToolBox aims at developing a “concept for proper maintenance planning” to assure the selection of adequate maintenance works (“schemes” or “objects”) to make effective use of the maintenance budget, based on available road condition data, to give minimal negative effects on road users, safety for road workers and the environment. This report covers the first phase of the ToolBox findings and development. In chapter 2 there are a discussion on technical parameters and the use of them. This is followed with a listing of available technical parameters in the partner countries, chapter 4. A state of the art covering how selections of maintenance candidates are done in the respective countries follows including a comprehensive reporting of indicators and parameters available. Finally the chapter 6 covers the selection of models that will be used to evaluate the functional performances decided.
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| 48. |
- Bengtsson, Johan, et al.
(författare)
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Modeling of Drivers' Longitudinal Behavior
- 2001
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Ingår i: Nonlinear and Hybrid Systems in Automotive Control. ; , s. 41-58
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Konferensbidrag (refereegranskat)abstract
- In the last few years, many vehicle manufacturers have introduced advance driver support in some of their automobiles. One of those new features is adaptive cruise control (ACC), which extends the conventional cruise control system to control of relative speed and distance to other vehicles. In order to design an ACC controller, it is suitable to have a model of drivers' behavior. Our approach to find dynamical models of the drivers' behavior was to use system identification. Basic data analysis is made by means of system identification methodology, and several models of drivers' longitudinal behavior are proposed, including both linear regression models and subspace-based models. In various situations, detection for when a driver's behavior changes or deviates from the normal is useful. To that purpose, a GARCH (generalized autoregressive conditional heteroskedasticity) model was used to model the driver in situations such as arousal.
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| 49. |
- Bengtsson, Johan, et al.
(författare)
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Modeling of Driver's Longitudinal Behavior
- 2003
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Ingår i: Nonlinear and Hybrid Systems in Automotive Control. - 076801137X ; , s. 41-58
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- In the last years, many vehicle manufacturers have introduced advancedriver support in some of their automobiles. One of those new featuresis Adaptive Cruise Control (ACC), which extends the conventionalcruise control system to control of relative speed and distance toother vehicles. In order to design an ACC controller it is suitable tohave a model on drivers' behavior. Our approach to find dynamicalmodels of the drivers' behavior was to use system identification.Basic data analysis was made by means of system identificationmethodology, and several models of drivers' longitudinal behavior areproposed, including both linear regression models and subspace basedmodels. Detection when a driver is changing his behavior in varioussituations to a deviant behavior is useful. To that purpose a GARCHmodel was used to model the driver in arousal situations, where thedriver changes behavior, is proposed.
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| 50. |
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