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- Kruger, C, et al.
(författare)
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The effects of egg-derived antibodies to glucosyltransferases on dental caries in rats
- 2004
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Ingår i: Caries research. - : S. Karger AG. - 0008-6568 .- 1421-976X. ; 38:1, s. 9-14
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Tidskriftsartikel (refereegranskat)abstract
- The role of <i>Streptococcus mutans</i> in the development of dental caries is well recognized. Important virulence factors include the glucosyltransferases (gtf), essential for production of glucans. We evaluated the anticariogenic effects of orally administered chicken anti-cell-associated (CA) Gtf antibodies in desalivated rats. The animals were infected with <i>S. mutans</i> MT8148R and treated with chicken anti-CA-Gtf egg yolk antibodies (IgY) or nonimmune egg yolk powder. Smooth surface lesions were significantly lower in the anti-CA-Gtf-treated group in comparison to the control groups. Sulcal surface caries was also decreased and of less severity. Our study suggests that chicken anti-CA-Gtf antibodies may have promise as a prophylaxis for high caries risk patients.
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