SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Spaak J) "

Sökning: WFRF:(Spaak J)

  • Resultat 111-111 av 111
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
111.
  • Wilms, Torben, et al. (författare)
  • PD-L1 in squamous cell carcinoma of the oral tongue shows gender-specific association with prognosis
  • 2020
  • Ingår i: Oral Diseases. - : John Wiley & Sons. - 1354-523X .- 1601-0825. ; 26:7, s. 1414-1423
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: To use alternative quantitation approaches to clarify the clinical implication of programmed cell death ligand 1 (PD‐L1) in squamous cell carcinoma of the oral tongue (SCCOT).Materials and Methods: Ventana SP263 immunohistochemistry assay and a multiplicative QuickScore method were applied to quantify PD‐L1 in tumor and surrounding immune cells from 101 patients with SCCOT. Tumor‐infiltrating immune cells were estimated from bulk tissue transcriptional profiles of 25 patients. Circulating PD‐L1 levels were measured in serum from 30 patients using an electrochemiluminescence assay platform.Results: We found higher tumor cell PD‐L1 levels in females than males (p  = .019). For patients with low PD‐L1 in tumor cells, better survival was seen in males than females (overall survival p  = .021, disease‐free survival p  = .020). Tumor‐infiltrating natural killer T cells, immature dendritic cells, and M1 macrophages were positively associated with tumor cell PD‐L1 (p  < .05).Conclusions: Our data confirmed the significance of gender on tumor cell PD‐L1 expression and demonstrated combined effects of gender and PD‐L1 levels on clinical outcome in patients with SCCOT. The data also indicated the involvement of specific immune cell types in PD‐L1‐regulated immune evasion.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 111-111 av 111

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy