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61.	Rheinbay, E, et al. (author) Analyses of non-coding somatic drivers in 2,658 cancer whole genomes 2020 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 102- Journal article (peer-reviewed)abstract The discovery of drivers of cancer has traditionally focused on protein-coding genes1–4. Here we present analyses of driver point mutations and structural variants in non-coding regions across 2,658 genomes from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium5 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). For point mutations, we developed a statistically rigorous strategy for combining significance levels from multiple methods of driver discovery that overcomes the limitations of individual methods. For structural variants, we present two methods of driver discovery, and identify regions that are significantly affected by recurrent breakpoints and recurrent somatic juxtapositions. Our analyses confirm previously reported drivers6,7, raise doubts about others and identify novel candidates, including point mutations in the 5′ region of TP53, in the 3′ untranslated regions of NFKBIZ and TOB1, focal deletions in BRD4 and rearrangements in the loci of AKR1C genes. We show that although point mutations and structural variants that drive cancer are less frequent in non-coding genes and regulatory sequences than in protein-coding genes, additional examples of these drivers will be found as more cancer genomes become available.
62.	Roth, GA, et al. (author) Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017 2018 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 392:10159, s. 1736-1788 Journal article (peer-reviewed)
63.	Sonderby, IE, et al. (author) Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs 2022 In: Human brain mapping. - : Wiley. - 1097-0193 .- 1065-9471. ; 43:1, s. 300-328 Journal article (peer-reviewed)
64.	Stewart, SE, et al. (author) Genome-wide association study of obsessive-compulsive disorder 2013 In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 18:7, s. 788-798 Journal article (peer-reviewed)
65.	Vlenterie, R, et al. (author) Associations Between Maternal Depression, Antidepressant Use During Pregnancy, and Adverse Pregnancy Outcomes: An Individual Participant Data Meta-analysis 2021 In: Obstetrics and gynecology. - 1873-233X. ; 138:4, s. 633-646 Journal article (peer-reviewed)
66.	Vos, T, et al. (author) Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 2016 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 388:10053, s. 1545-1602 Journal article (peer-reviewed)
67.	Yakneen, S, et al. (author) Butler enables rapid cloud-based analysis of thousands of human genomes 2020 In: Nature biotechnology. - : Springer Science and Business Media LLC. - 1546-1696 .- 1087-0156. ; 38:3, s. 288- Journal article (peer-reviewed)abstract We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.
68.	Yakneen, S, et al. (author) Publisher Correction: Butler enables rapid cloud-based analysis of thousands of human genomes 2023 In: Nature biotechnology. - : Springer Science and Business Media LLC. - 1546-1696 .- 1087-0156. ; 41:4, s. 578-578 Journal article (other academic/artistic)abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
69.	Yu, DM, et al. (author) Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD 2015 In: The American journal of psychiatry. - : American Psychiatric Association Publishing. - 1535-7228 .- 0002-953X. ; 172:1, s. 82-93 Journal article (peer-reviewed)
70.	Zhou, B, et al. (author) Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants 2018 In: International journal of epidemiology. - : Oxford University Press (OUP). - 1464-3685 .- 0300-5771. ; 47:3, s. 872- Journal article (peer-reviewed)

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Result 61-70 of 72

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Type of publication: journal article (70); conference paper (1); research review (1)

Type of content: peer-reviewed (67); other academic/artistic (5)

Author/Editor: Stein, DJ (37); Jonas, JB (31); Gupta, R. (29); Shiri, R (29); Brenner, H (26); Sepanlou, SG (26); show more...; Malekzadeh, R (25); Lotufo, PA (24); Farzadfar, F (23); Khader, YS (23); Topor-Madry, R (23); Panda-Jonas, S (22); Silva, DAS (22); Mokdad, AH (21); Bensenor, IM (20); Bhutta, ZA (20); Fischer, F (20); Islam, SMS (20); Mckee, M (20); Monasta, L (20); Nagel, G (20); Nangia, V (20); Shaikh, MA (20); Shibuya, K (20); Venketasubramanian, ... (20); Banach, M (19); Gill, TK (19); Khang, YH (19); Lee, PH (19); Meretoja, A (19); Ronfani, L (19); Sachdev, PS (19); Santos, IS (19); Schutte, AE (19); Singh, JA (19); Vos, T (19); Barker-Collo, SL (18); Davletov, K (18); Djalalinia, S (18); Hankey, GJ (18); Hay, SI (18); Majeed, A (18); Malta, DC (18); Miller, TR (18); Mohammadifard, N (18); Oh, IH (18); Roshandel, G (18); Shigematsu, M (18); Tabares-Seisdedos, R (18); Thankappan, KR (18); show less...

University: Karolinska Institutet (70); Uppsala University (28); University of Gothenburg (21); Lund University (21); Högskolan Dalarna (15); Umeå University (10); show more...; University of Skövde (5); Chalmers University of Technology (3); Stockholm University (1); Örebro University (1); Stockholm School of Economics (1); Mid Sweden University (1); Södertörn University (1); show less...

Language: English (72)

Research subject (UKÄ/SCB): Medical and Health Sciences (40); Natural sciences (3); Social Sciences (1)

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