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Träfflista för sökning "WFRF:(Viitanen M) "

Search: WFRF:(Viitanen M)

  • Result 41-50 of 219
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43.
  • Cornelius, C, et al. (author)
  • : prevalence and association with drug use
  • 1997
  • In: Clinical drug investigation. - : Springer Science and Business Media LLC. - 1173-2563. ; 13:2, s. 105-117
  • Journal article (peer-reviewed)
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44.
  • Cornelius, C, et al. (author)
  • Self-reported symptoms in the elderly and association with drug use
  • 1997
  • In: Clinical drug investigation. - 1173-2563 .- 1179-1918. ; 13:2, s. 105-117
  • Journal article (peer-reviewed)abstract
    • Summary: In a cross-sectional study, we have investigated the prevalence of self-reported symptoms and their association with medicinal drug use in elderly people. Data from the Kungsholmen Project were used, a population-based study of elderly people aged 75 years and over in Stockholm, Sweden. The study sample comprised 1800 persons. Information on the occurrence of 22 different symptoms and the actual drug use was obtained at interviews with the participants. The relation of symptoms to age, gender and housing, and their association with drug use was analysed using logistic regression. The most commonly reported symptoms were pain and tiredness. In general, symptoms were more common in women and at higher ages. Many of the associations between symptoms and drug use reflected established treatments. However, some were suggestive of inappropriate treatment or dosage; for example, the association between tiredness and the use of anxiolytics and hypnotics-sedatives.
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47.
  • Heikela, H., et al. (author)
  • Hydroxysteroid (17 beta) dehydrogenase 12 is essential for metabolic homeostasis in adult mice
  • 2020
  • In: American Journal of Physiology-Endocrinology and Metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 319:3
  • Journal article (peer-reviewed)abstract
    • Hydroxysteroid 17 beta dehydrogenase 12 (HSD17B12) is suggested to be involved in the elongation of very long chain fatty acids. Previously. we have shown a pivotal role for the enzyme during mouse development. In the present study we generated a conditional Hsd17b12 knockout (HSD17B12cKO) mouse model by breeding mice homozygous for a floxed Hsd17b12 allele with mice expressing the tamoxifen-inducible Cre recombinase at the ROSA26 locus. Gene inactivation was induced by administering tamoxifen to adult mice. The gene inactivation led to a 20% loss of body weight within 6 days, associated with drastic reduction in both white (83% males, 75% females) and brown (65% males. 60% females) fat, likely due to markedly reduced food and water intake. Furthermore, the knockout mice showed sickness behavior and signs of liver toxicity. specifically microvesicular hepatic steatosis and increased serum alanine aminotransferase (4.6-fold in males, 7.7-fold in females). The hepatic changes were more pronounced in females than males. Proinflammatory cytokines, such as interleukin-6 (IL-6), IL-17, and granulocyte colony-stimulating factor, were increased in the HSD17B12cKO mice indicating an inflammatory response. Serum lipidomics study showed an increase in the amount of dihydroceramides, despite the dramatic overall loss of lipids. In line with the proposed role for HSD17B12 in fatty acid elongation, we observed accumulation of ceramides, dihydroceramides, hexosylceramides, and lactosylceramides with shorter than 18-carbon fatty acid side chains in the serum. The results indicate that HSD17B12 is essential for proper lipid homeostasis and HSD17B12 deficiency rapidly results in fatal systemic inflammation and lipolysis in adult mice.
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  • Result 41-50 of 219
Type of publication
journal article (194)
conference paper (21)
book chapter (3)
doctoral thesis (1)
Type of content
peer-reviewed (176)
other academic/artistic (43)
Author/Editor
Viitanen, M (207)
Winblad, B (75)
Fratiglioni, L (35)
Kalimo, H (26)
Lannfelt, L (24)
Rinne, JO (17)
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Poyhonen, M (16)
Guo, ZC (15)
Fastbom, J (12)
Kallio, H. (12)
Vahlberg, T (12)
Johansson, K (11)
Almkvist, O (11)
Basun, H (11)
Backman, L (9)
Amberla, K (9)
Holm-Pedersen, P (9)
Aguero-Torres, H (8)
Axelman, K (8)
Mykkanen, K (8)
Baumann, M (8)
Nagren, K (7)
Wahlund, LO (7)
Kalaria, RN (7)
von Strauss, Eva (7)
Tuisku, S (7)
Avlund, K (7)
Viikari, L (7)
Lilius, L (7)
Salminen, M. (7)
Aalto, S (6)
Kivipelto, M (6)
Nordberg, A (6)
Soininen, H (6)
Behbahani, H (6)
Helin, S (6)
Tikka, S (6)
Lehtonen, A (6)
Panahi, M (5)
Zhu, L (5)
Hardy, J (5)
Kareholt, I (5)
Tuomilehto, J. (5)
Jarvinen, R. (5)
Nissinen, A (5)
Helkala, EL (5)
Jula, A. (5)
Small, BJ (5)
Corder, EH (5)
Cornelius, C (5)
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University
Karolinska Institutet (200)
Uppsala University (17)
University of Gothenburg (7)
Red Cross University College (7)
Lund University (5)
Umeå University (2)
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Stockholm University (2)
Royal Institute of Technology (1)
Halmstad University (1)
Linköping University (1)
Jönköping University (1)
Chalmers University of Technology (1)
RISE (1)
Marie Cederschiöld högskola (1)
Swedish University of Agricultural Sciences (1)
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Language
English (218)
Swedish (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (14)
Natural sciences (4)
Social Sciences (3)
Engineering and Technology (1)

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