| 171. |
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| 172. |
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| 173. |
- Rana, A.K.M. Masud, et al.
(författare)
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Association of bone and joint diseases with health-related quality of life among older people : a population-based cross-sectional study in rural Bangladesh
- 2009
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Ingår i: Ageing & Society. - : Cambridge University Press. - 0144-686X .- 1469-1779. ; 29:5, s. 727-743
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Tidskriftsartikel (refereegranskat)abstract
- This study examined the cross-sectional association of bone and joint diseases with health-related quality of life (HRQoL) among 850 randomly sampled people aged 60 or more years in a rural area of Bangladesh. Information about arthritis, back and joint pain was collected through self-reports and two physicians' assessments at a health centre. Health-related quality of life was measured using a multi-dimensional generic instrument designed for older people that has questions on the construct's physical, psychological, social, economic, spiritual and environmental dimensions. Bivariate analyses showed that the most negative effects of bone and joint diseases were on the physical and psychological dimensions. Hierarchical linear regression analyses revealed that joint pain, whether doctor-diagnosed or self-reported, and self-reported back pain were all associated with lower HRQoL scores and accounted for almost 20 per cent of the variation (adjusted for age, sex, education, marital status, household size, income, expenditure and occupation). The analyses further revealed that women with self-reported back pain had significantly lower psychological, environmental and overall HRQoL scores than equivalent men, while self-reported joint pain was associated with significantly lower scores only for the environmental dimension. The strong association of bone and joint diseases with HRQoL underscores the importance of regarding these illnesses as public health problems.
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| 174. |
- Rana, A. K. M. M., et al.
(författare)
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Health education improves both arthritis-related illness and self-rated health : An intervention study among older people in rural Bangladesh
- 2010
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Ingår i: Public Health. - : Elsevier BV. - 0033-3506 .- 1476-5616. ; 124:12, s. 705-712
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: To examine changes in self-reported arthritis-related illness and self-rated health as a result of a health education intervention, and the association between self-reported arthritis-related illness and self-rated health. Study design: A quasi-experimental study was conducted in eight randomly selected villages in rural Bangladesh (intervention = 4; control = 4). Methods: The intervention consisted of home-based physical activities, health advice and aspects of healthcare management over 15 months followed by a 3-month latent period. Data were collected before the intervention and after the latent period. Analyses included 839 participants (>= 60 years of age) who participated in both surveys. Participants in the intervention area were further categorized into two groups who self-reported compliance or non-compliance with recommended health advice. Self-rated health was assessed using a single global question. Self-reported arthritis-related illness was indicated by the presence of arthritis, back and joint pain, biting sensation, swelling and inflammation in the joints. Results: Hierarchical logistic regression analyses revealed that positive effects on episodes of arthritis-related illness [ odds ratio (OR) 1.9, 95% confidence interval (CI) 1.3-2.8] and self-rated health (OR 1.4, 95% CI 1.0-1.9) were more likely among the compliant group compared with the control group. Furthermore, positive self-rated health was more likely among participants reporting a positive change in their arthritis-related illness (OR 2.2, 95% CI 1.5-3.2). The results also showed that literate and non-poor participants were more likely to report positive health, and participants with advancing age were less likely to report positive health. Conclusion: Community-based health education is effective in reducing the burden of arthritis-related illness and in enhancing general health in old age.
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| 175. |
- Rana, A.K.M. Masud, et al.
(författare)
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Impact of health education on health-related quality of life among elderly persons : results from a community-based intervention study in rural Bangladesh
- 2009
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Ingår i: Health Promotion International. - : Oxford University Press. - 0957-4824 .- 1460-2245. ; 24:1, s. 36-45
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Tidskriftsartikel (refereegranskat)abstract
- This study examines the change in health-related quality oflife (HRQoL) among (60 years) elderly persons as a result ofhealth education intervention. A community-based interventionstudy was performed in eight randomly selected villages (Intervention:n = 4; Control: n = 4) in rural Bangladesh. A total of 1135elderly persons was selected for this study. The analyses include839 participants (Intervention: n = 425; Control: n = 414) whoparticipated in both baseline and post-intervention surveys.Participants in the intervention area were further stratifiedinto compliant (n = 315) and non-compliant (n = 110) groupsbased on the reported compliance to the intervention activities.The intervention includes, for example, physical activity, adviceon healthy food intake and other aspects of management. To createan enabling environment, social awareness was provided by meansof information about the contribution of and challenges facedby elderly persons at home and the community, including informationabout elderly persons' health and health care. The interventionactivities were provided to the elderly persons, caregivers,household members and community people for 15 months. The HRQoLwas assessed using a multi-dimensional generic instrument designedfor elderly persons. Multivariate analyses revealed that inthe non-compliant group the probabilities of increased scoreswere less likely in overall HRQoL (OR 0.52, 95% CI 0.32–0.82).Among the Control group, increased scores were less likely inthe physical (OR 73, 95% CI 0.54–0.99), social (OR 0.37,95% CI 0.27–0.50), spiritual (OR 0.60, 95% CI 0.34–0.94),environment (OR 0.36, 95% CI 0.26–0.49) dimensions andoverall HRQoL (OR 0.44, 95% CI 0.32–0.59) (adjusted forage, sex, literacy, marital status and economic status). Thisstudy concludes that provision of community-based health educationintervention might be a potential public health initiative toenhance the HRQoL in old age.
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| 176. |
- Rana, A.K.M. Masud, et al.
(författare)
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The impact of health education in managing self-reported arthritis-related illness among elderly persons in rural Bangladesh
- 2008
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Ingår i: Health Education Research. - Oxford : Oxford University Press. - 0268-1153 .- 1465-3648. ; 23:1, s. 94-105
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Tidskriftsartikel (refereegranskat)abstract
- This study examines the impact of health education on prevalenceof and expenditure on treatment of self-reported arthritis-relatedillness among elderly persons in rural Bangladesh. An interventionstudy was conducted, including 1135 elderly persons (60 years)from eight randomly selected villages, four each of an interventionand a control area. The analyses include 839 elderly personswho participated in both pre- and post-intervention surveys(intervention area: n = 425, control area: n = 414). Participantsof the intervention area were further categorized as compliant(n = 315) and non-compliant (n = 110) based on adherence tothe intervention instructions. The intervention that lastedfor 15 months comprised home-based physical exercise, dietaryinstructions and other aspects of management. Results show thatalthough there was no significant difference in self-reportedarthritis-related illness between the compliant and non-compliantgroups at baseline, it was significantly lower in the compliantgroup (71%) at post-intervention compared with the non-compliant(81%). Related monthly expenditure on treatment was significantlyreduced in the compliant group (from Taka 104 to Taka 52) butnot in the other two groups. Logistic regressions further showedthat the control group had a higher probability of increasedtreatment-related expenditure compared with the compliant group(OR 2.0, 95% CI 1.4–2.8).
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| 177. |
- Sandström, Herbert, et al.
(författare)
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Congenital dyserythropoietic anemia type III.
- 2000
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Ingår i: Haematologica. - 0390-6078 .- 1592-8721. ; 85:7, s. 753-7
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND OBJECTIVES: Congenital dyserythropoietic anemia type III (CDA-III) is a group of very rare disorders characterized by similar bone marrow morphology. The clinical picture is characterized by hemolytic anemia and dramatic bone marrow changes dominated by active erythropoiesis with big multinucleated erythroblasts. The aim of this review is to describe the clinical manifestations, laboratory findings, and management CDA-III.EVIDENCE AND INFORMATION SOURCES: The present review critically examines relevant articles and abstracts published in journals covered by the Science Citation Index and Medline. The authors have performed several studies on CDA-III.STATE OF ART AND PERSPECTIVES: The clinical and laboratory manifestations of CDA-III indicate that the gene responsible for it, which has been mapped to chromosome 15q22, is expressed not only in erythroblasts during mitosis but also in B-cells, and in cells of the retina. Preliminary results indicate genetic and phenotypic similarities between a Swedish and an American family, both with an autosomally dominant inherited form of CDA-III. It is possible that the genetic lesion is identical in these families, but the different phenotypes and modes of inheritance reported among some other cases of CDA-III are probably the results of other genetic lesions. At present, the function of the gene responsible for the Swedish (V sterbotten) variant of CDA-III (CDAN3) is unknown and it is an important goal to characterize and clone this gene in order to study its function.
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| 178. |
- Sandström, Herbert, et al.
(författare)
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Intravascular haemolysis and increased prevalence of myeloma and monoclonal gammopathy in congenital dyserythropoietic anaemia, type III.
- 1994
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Ingår i: European Journal of Haematology. - 0902-4441 .- 1600-0609. ; 52:1, s. 42-6
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Tidskriftsartikel (refereegranskat)abstract
- A family with congenital dyserythropoietic anaemia type III was studied. Twenty patients and 10 of their healthy siblings were clinically examined and questioned about their medical history. Blood sampling and bone marrow aspirations were also performed. Forty-five percent of the patients reported symptoms of anaemia and 35% regularly felt weakness, fatigue, or headache. However, the majority of the patients regarded themselves as healthy. The bone marrow showed a uniform picture of erythroid hyperplasia with multinuclear erythroblasts and gigantoblasts with up to 12 nuclei. There was laboratory evidence of intravascular haemolysis and mild anaemia. We also observed a high prevalence of monoclonal gammopathy of undetermined significance (3 cases) and myeloma (1 case) among the patients.
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| 179. |
- Sandström, Herbert, et al.
(författare)
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[Localized gene of the rare "Norrland disease". CDA-III blood disease with dominant heredity].
- 1999
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Ingår i: Läkartidningen. - 0023-7205 .- 1652-7518. ; 96:4, s. 343-7
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Tidskriftsartikel (refereegranskat)abstract
- The article consists in a review of available knowledge of the rare blood disorder, congenital dyserythropoietic anaemia, type III (CDA-III), a disease characterised by autosomal dominant heredity, and mild to moderate haemolytic anaemia. The gene causing CDA-III has been localised on chromosome 15q22. Most patients are adapted to their disease, and have few or no overt manifestations. Bone marrow examination yields a characteristic picture of erythroid hyperplasia and multinucleate erythroblasts. A Swedish family affected with CDA-III has been reported to be characterised by a high prevalence of monoclonal gammopathy and angioid streaks, a triad suggested by the authors to represent a hitherto unreported syndrome.
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| 180. |
- Sandström, Herbert, et al.
(författare)
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Serum thymidine kinase in congenital dyserythropoietic anaemia type III.
- 1994
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Ingår i: British Journal of Haematology. - 0007-1048 .- 1365-2141. ; 87:3, s. 653-4
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Tidskriftsartikel (refereegranskat)abstract
- Serum thymidine kinase (TK) was determined in a family with congenital dyserythropoietic anaemia type III (CDA, type III). 20 patients and 10 of their healthy siblings were investigated. Elevated TK was found in all 20 patients (median 56.2 U) but their healthy siblings had normal values (median 2.65 U). We suggest that determination of TK should be used for discrimination between healthy siblings and individuals affected by CDA type III when bone marrow examination is not suitable.
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