| 4711. |
- Sodhro, Ali Hassan, et al.
(författare)
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Towards 5G-Enabled Self Adaptive Green and Reliable Communication in Intelligent Transportation System
- 2021
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Ingår i: IEEE transactions on intelligent transportation systems (Print). - : IEEE. - 1524-9050 .- 1558-0016. ; 22:8, s. 5223-5231
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Tidskriftsartikel (refereegranskat)abstract
- Fifth generation (5G) technologies have become the center of attention in managing and monitoring high-speed transportation system effectively with the intelligent and self-adaptive sensing capabilities. Besides, the boom in portable devices has witnessed a huge breakthrough in the data driven vehicular platform. However, sensor-based Internet of Things (IoT) devices are playing the major role as edge nodes in the intelligent transportation system (ITS). Thus, due to high mobility/speed of vehicles and resource-constrained nature of edge nodes more data packets will be lost with high power drain and shorter battery life. Thus, this research significantly contributes in three ways. First, 5G-based self-adaptive green (i.e., energy efficient) algorithm is proposed. Second, a novel 5G-driven reliable algorithm is proposed. Proposed joint energy efficient and reliable approach contains four layers, i.e., application, physical, networks, and medium access control. Third, a novel joint energy efficient and reliable framework is proposed for ITS. Moreover, the energy and reliability in terms of received signal strength (RSSI) and hence packet loss ratio (PLR) optimization is performed under the constraint that all transmitted packets must utilize minimum transmission power with high reliability under particular active time slot. Experimental results reveal that the proposed approach (with Cross Layer) significantly obtains the green (55%) and reliable (41%) ITS platform unlike the Baseline (without Cross Layer) for aging society.
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| 4712. |
- Soler, J. D., et al.
(författare)
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Histogram of oriented gradients: a technique for the study of molecular cloud formation
- 2019
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 622
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Tidskriftsartikel (refereegranskat)abstract
- We introduce the histogram of oriented gradients (HOG), a tool developed for machine vision that we propose as a new metric for the systematic characterization of spectral line observations of atomic and molecular gas and the study of molecular cloud formation models. In essence, the HOG technique takes as input extended spectral-line observations from two tracers and provides an estimate of their spatial correlation across velocity channels. We characterized HOG using synthetic observations of HI and (CO)-C-13(J = 1 -> 0) emission from numerical simulations of magnetohydrodynamic (MHD) turbulence leading to the formation of molecular gas after the collision of two atomic clouds. We found a significant spatial correlation between the two tracers in velocity channels where v(HI) approximate to v(13CO), almost independent of the orientation of the collision with respect to the line of sight. Subsequently, we used HOG to investigate the spatial correlation of the HI, from The HI/OH/recombination line survey of the inner Milky Way (THOR), and the (CO)-C-13(J = 1 -> 0) emission from the Galactic Ring Survey (GRS), toward the portion of the Galactic plane 33.degrees 75 <= l <= 35.degrees 25 and vertical bar b vertical bar <= 1.degrees 25. We found a significant spatial correlation between the two tracers in extended portions of the studied region. Although some of the regions with high spatial correlation are associated with HI self-absorption (HISA) features, suggesting that it is produced by the cold atomic gas, the correlation is not exclusive to this kind of region. The HOG results derived for the observational data indicate significant differences between individual regions: some show spatial correlation in channels around v(HI) approximate to v(13CO) while others present spatial correlations in velocity channels separated by a few kilometers per second. We associate these velocity offsets to the effect of feedback and to the presence of physical conditions that are not included in the atomic-cloud-collision simulations, such as more general magnetic field configurations, shear, and global gas infall.
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| 4713. |
- Solomon, S. D., et al.
(författare)
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Influence of ejection fraction on cardiovascular outcomes in a broad spectrum of heart failure patients
- 2005
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Ingår i: Circulation. - 1524-4539. ; 112:24, s. 3738-44
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Left ventricular function is a principal determinant of cardiovascular risk in patients with heart failure. The growing number of patients with preserved systolic function heart failure underscores the importance of understanding the relationship between ejection fraction and risk. METHODS AND RESULTS: We studied 7599 patients with a broad spectrum of symptomatic heart failure enrolled in the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) Program. All patients were randomized to candesartan at a target dose of 32 mg once daily or matching placebo and followed up for a median of 38 months. We related left ventricular ejection fraction (LVEF), measured before randomization at the sites, to cardiovascular outcomes and causes of death. Mean LVEF in patients enrolled in CHARM was 38.8+/-14.9% (median LVEF 36%). Patients with lower LVEF tended to have higher baseline New York Heart Association class. The hazard ratio for all-cause mortality increased by 39% for every 10% reduction in ejection fraction below 45% (hazard ratio 1.39, 95% CI 1.32 to 1.46), with adjustment for baseline covariates. All-cause mortality, cardiovascular death, and all components of cardiovascular death declined with increasing ejection fraction until an ejection fraction of 45%, after which the risk of these outcomes remained relatively stable with increasing LVEF. The absolute change in rate per 100 patient-years for each 10% reduction in LVEF was greatest for sudden death and heart failure-related death. The effect of candesartan in reducing cardiovascular outcomes was consistent across LVEF categories. CONCLUSIONS: LVEF is a powerful predictor of cardiovascular outcome in heart failure patients across a broad spectrum of ventricular function. Nevertheless, once elevated to a range above 45%, ejection fraction does not further contribute to assessment of cardiovascular risk in heart failure patients.
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| 4714. |
- Solorzano, Leslie, 1989-, et al.
(författare)
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Machine learning for cell classification and neighborhood analysis in glioma tissue
- 2021
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Ingår i: Cytometry Part A. - : Wiley. - 1552-4922 .- 1552-4930. ; 99:12, s. 1176-1186
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Tidskriftsartikel (refereegranskat)abstract
- Multiplexed and spatially resolved single-cell analyses that intend to study tissue heterogeneity and cell organization invariably face as a first step the challenge of cell classification. Accuracy and reproducibility are important for the downstream process of counting cells, quantifying cell-cell interactions, and extracting information on disease-specific localized cell niches. Novel staining techniques make it possible to visualize and quantify large numbers of cell-specific molecular markers in parallel. However, due to variations in sample handling and artifacts from staining and scanning, cells of the same type may present different marker profiles both within and across samples. We address multiplexed immunofluorescence data from tissue microarrays of low-grade gliomas and present a methodology using two different machine learning architectures and features insensitive to illumination to perform cell classification. The fully automated cell classification provides a measure of confidence for the decision and requires a comparably small annotated data set for training, which can be created using freely available tools. Using the proposed method, we reached an accuracy of 83.1% on cell classification without the need for standardization of samples. Using our confidence measure, cells with low-confidence classifications could be excluded, pushing the classification accuracy to 94.5%. Next, we used the cell classification results to search for cell niches with an unsupervised learning approach based on graph neural networks. We show that the approach can re-detect specialized tissue niches in previously published data, and that our proposed cell classification leads to niche definitions that may be relevant for sub-groups of glioma, if applied to larger data sets.
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| 4715. |
- Sonderby, Ida E., et al.
(författare)
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Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
- 2020
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Ingår i: Molecular Psychiatry. - : Nature Publishing Group. - 1359-4184 .- 1476-5578. ; 25:3, s. 584-602
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Tidskriftsartikel (refereegranskat)abstract
- Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = −0.71 to −1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = −0.95, P = 0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P = 0.0032, 8.9 × 10−6, 1.7 × 10−9, 3.5 × 10−12 and 1.0 × 10−4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non-carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.
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| 4716. |
- Song, C.X., et al.
(författare)
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Large-scale multiconfiguration Dirac-Hartree-Fock calculations for astrophysics : n=4 levels in P-like ions from Mn XIto Ni XIV
- 2020
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Ingår i: Astrophysical Journal Supplement Series. - : Institute of Physics (IOP). - 0067-0049 .- 1538-4365. ; 247:70, s. 1-11
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Tidskriftsartikel (refereegranskat)abstract
- Using the multiconfiguration Dirac–Hartree–Fock and the relativistic configuration interaction methods, a consistent set of transition energies and radiative transition data for the lowest 546 (623, 701, and 745) states of the , , , , , , , , , , , , , , , and configurations in Mn xi (Fe xii, Co xiii, and Ni xiv) is provided. The comparison between calculated excitation energies for the n = 4 states and available experimental values for Fe xii indicate that the calculations are highly accurate, with uncertainties of only a few hundred cm−1. Lines from these states are prominent in the soft X-rays. With the present calculations, several recent new identifications are confirmed. Other identifications involving levels in Fe xii that were found to be questionable are discussed and a few new assignments are recommended. As some n = 4 states of the other ions also show large discrepancies between experimental and calculated energies, we reassess their identification. The present study provides highly accurate atomic data for the n = 4 states of P-like ions of astrophysical interest, for which experimental data are scarce.
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| 4717. |
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| 4718. |
- Song, J., et al.
(författare)
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Parameter optimization analysis of rotary electromagnetic vibration energy harvester for performance enhancement under free vibration
- 2023
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Ingår i: iScience. - : Elsevier Inc.. - 2589-0042. ; 26:10
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, three new important aspects of rotary electromagnetic vibration energy harvesting technology (RE-VEH) are concerned and investigated: (i) vibro-electric coupling mechanism of the RE-VEH system is studied through theoretical modeling; (ii) quantitative analysis of system parameters based on numerical simulation method is carried out for the optimal design of RE-VEH; and (iii) dynamic power output performance of the RE-VEH system in free vibration is discussed. The parameter adjusting methods of the RE-VEH system in free vibration mode are obtained through theoretical analysis and numerical simulation. The experimental results show that the power output performance of RE-VEH in free vibration mode matches the numerical simulation results. The simulation and experimental results show that the maximum voltage output and power output of the RE-VEH with different structure parameters under free vibration can be up to the level of 100∼101 V/watt. The above results indicate that RE-VEH in a free vibration environment has significant energy output performance.
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| 4719. |
- Song, Lingyun, et al.
(författare)
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Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity
- 2011
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Ingår i: Genome Research. - : Cold Spring Harbor Laboratory. - 1088-9051 .- 1549-5469. ; 21:10, s. 1757-1767
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Tidskriftsartikel (refereegranskat)abstract
- The human body contains thousands of unique cell types, each with specialized functions. Cell identity is governed in large part by gene transcription programs, which are determined by regulatory elements encoded in DNA. To identify regulatory elements active in seven cell lines representative of diverse human cell types, we used DNase-seq and FAIRE-seq (Formaldehyde Assisted Isolation of Regulatory Elements) to map open chromatin.'' Over 870,000 DNaseI or FAIRE sites, which correspond tightly to nucleosome-depleted regions, were identified across the seven cell lines, covering nearly 9% of the genome. The combination of DNaseI and FAIRE is more effective than either assay alone in identifying likely regulatory elements, as judged by coincidence with transcription factor binding locations determined in the same cells. Open chromatin common to all seven cell types tended to be at or near transcription start sites and to be coincident with CTCF binding sites, while open chromatin sites found in only one cell type were typically located away from transcription start sites and contained DNA motifs recognized by regulators of cell-type identity. We show that open chromatin regions bound by CTCF are potent insulators. We identified clusters of open regulatory elements (COREs) that were physically near each other and whose appearance was coordinated among one or more cell types. Gene expression and RNA Pol II binding data support the hypothesis that COREs control gene activity required for the maintenance of cell-type identity. This publicly available atlas of regulatory elements may prove valuable in identifying noncoding DNA sequence variants that are causally linked to human disease.
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| 4720. |
- Song, S. S., et al.
(författare)
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A global assessment of the mixed layer in coastal sediments and implications for carbon storage
- 2022
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- The sediment-water interface in the coastal ocean is a highly dynamic zone controlling biogeochemical fluxes of greenhouse gases, nutrients, and metals. Processes in the sediment mixed layer (SML) control the transfer and reactivity of both particulate and dissolved matter in coastal interfaces. Here we map the global distribution of the coastal SML based on excess Pb-210 (Pb-210(ex)) profiles and then use a neural network model to upscale these observations. We show that highly dynamic regions such as large estuaries have thicker SMLs than most oceanic sediments. Organic carbon preservation and SMLs are inversely related as mixing stimulates oxidation in sediments which enhances organic matter decomposition. Sites with SML thickness >60 cm usually have lower organic carbon accumulation rates (<50 g C m(-2) yr(-1)) and total organic carbon/specific surface area ratios (<0.4 mg m(-2)). Our global scale observations reveal that reworking can accelerate organic matter degradation and reduce carbon storage in coastal sediments. The authors map the global distribution of the mixed layer in coastal ocean sediments, based on a neural network model. These observations reveal that mixing can accelerate organic matter degradation and reduce carbon storage in the coastal ocean.
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