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  • Result 661-670 of 770
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661.
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662.
  • Northcott, Paul A, et al. (author)
  • Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
  • 2014
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 511:7510, s. 428-428
  • Journal article (peer-reviewed)abstract
    • Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to the developing child. Genomics has illuminated the extensive intertumoral heterogeneity of medulloblastoma, identifying four distinct molecular subgroups. Group 3 and group 4 subgroup medulloblastomas account for most paediatric cases; yet, oncogenic drivers for these subtypes remain largely unidentified. Here we describe a series of prevalent, highly disparate genomic structural variants, restricted to groups 3 and 4, resulting in specific and mutually exclusive activation of the growth factor independent 1 family proto-oncogenes, GFI1 and GFI1B. Somatic structural variants juxtapose GFI1 or GFI1B coding sequences proximal to active enhancer elements, including super-enhancers, instigating oncogenic activity. Our results, supported by evidence from mouse models, identify GFI1 and GFI1B as prominent medulloblastoma oncogenes and implicate 'enhancer hijacking' as an efficient mechanism driving oncogene activation in a childhood cancer.
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663.
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664.
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665.
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666.
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667.
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668.
  • Pelet, J. -É, et al. (author)
  • Don’t believe the hype : a grounded exploratory six country wine purchasing study
  • 2017
  • In: Journal of Wine Research. - : Routledge. - 0957-1264 .- 1469-9672. ; 28:2, s. 91-104
  • Journal article (peer-reviewed)abstract
    • The purpose of this exploratory study was to understand the extent that consumers report purchasing wine on mobile devices and to empirically examine potential drivers of m-wine purchasing across six countries to guide theoretical research enquiry moving forward. Purposive sampling was employed. An online survey involving 2853 respondents from France, Germany, Greece, Canada, US and South Africa forms the basis for the current study. The results of the study indicate that though mobile phone usage, wine consumption and purchasing rates are high, mobile-wine purchasing prevalence is low within all six countries. While technology hype has us believe an online presence is essential for business revenue growth and performance; the current study indicates wineries should carefully consider consumer readiness towards mobile-wine purchasing. Limitations and recommendations for future research are identified.
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669.
  • Peretti, R., et al. (author)
  • Room temperature operation of a deep etched buried heterostructure photonic crystal quantum cascade laser
  • 2016
  • In: Laser & Photonics reviews. - : Wiley-VCH Verlagsgesellschaft. - 1863-8880 .- 1863-8899. ; 10:5, s. 843-848
  • Journal article (peer-reviewed)abstract
    • High power single mode quantum cascade lasers with a narrow far field are important for several applications including surgery or military countermeasure. Existing technologies suffer from drawbacks such as operation temperature and scalability. In this paper we introduce a fabrication approach that potentially solves simultaneously these remaining limitations. We demonstrate and characterize deep etched, buried photonic crystal quantum cascade lasers emitting around a wavelength of 8.5 μm. The active region was dry etched before being regrown with semi-insulating Fe:InP. This fabrication strategy results in a refractive index contrast of 10% allowing good photonic mode control, and simultaneously provides good thermal extraction during operation. Single mode emission with narrow far field pattern and peak powers up to 0.88 W at 263 K were recorded from the facet of the photonic crystal laser, and lasing operation was maintained up to room temperature. The lasing modes emitted from square photonic crystal mesas with a side length of 550μm, were identified as slow Bloch photonic crystal modes by means of three-dimensional photonic simulations and measurements. (Figure presented.).
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670.
  • Peretti, R., et al. (author)
  • Room temperature operation of a photonic crystal quantum cascade laser
  • 2015
  • In: Conference on Lasers and Electro-Optics Europe - Technical Digest. - : Institute of Electrical and Electronics Engineers Inc..
  • Conference paper (peer-reviewed)abstract
    • We report on design, fabrication and investigation of a buried heterostructure photonic crystal quantum cascade laser operating in the mid-IR (8.5μm) at room temperature, leading to single mode emission on a 600μm by 600μm mesa. 
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  • Result 661-670 of 770
Type of publication
journal article (704)
conference paper (36)
research review (16)
other publication (3)
book chapter (3)
book (1)
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doctoral thesis (1)
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Type of content
peer-reviewed (718)
other academic/artistic (46)
Author/Editor
Montaruli, T. (139)
Kappes, A. (137)
Karg, T. (137)
Aguilar, J. A. (135)
Madsen, J. (134)
De Clercq, C. (132)
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Schmidt, T. (131)
Tilav, S. (131)
Kolanoski, H. (130)
Zhang, Z. (130)
Bai, X. (130)
Kowalski, M. (130)
Grant, D. (130)
Helbing, K. (130)
Hoffman, K. D. (130)
Hoshina, K. (130)
Ishihara, A. (130)
Karle, A. (130)
Kiryluk, J. (130)
Meagher, K. (130)
Naumann, U. (130)
Olivas, A. (130)
Rawlins, K. (130)
Resconi, E. (130)
Rhode, W. (130)
Rott, C. (130)
Ruhe, T. (130)
Ryckbosch, D. (130)
Stanev, T. (130)
Stezelberger, T. (130)
Taboada, I. (130)
van Santen, J. (130)
Wendt, C. (130)
Williams, D. R. (130)
Xu, X. W. (130)
Berley, D. (129)
Bernardini, E. (129)
Blaufuss, E. (129)
Desiati, P. (129)
Fazely, A. R. (129)
Gerhardt, L. (129)
Halzen, F. (129)
Hickford, S. (129)
Hultqvist, K. (129)
Przybylski, G. T. (129)
Sarkar, S. (129)
Seckel, D. (129)
Seunarine, S. (129)
Spiering, C. (129)
Wiebusch, C. H. (129)
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University
Uppsala University (232)
Karolinska Institutet (231)
Stockholm University (203)
Lund University (184)
University of Gothenburg (81)
Chalmers University of Technology (49)
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Umeå University (43)
Royal Institute of Technology (17)
Linköping University (15)
Linnaeus University (14)
Högskolan Dalarna (6)
Swedish University of Agricultural Sciences (6)
Örebro University (5)
University of Gävle (4)
Luleå University of Technology (3)
RISE (3)
Karlstad University (3)
Malmö University (2)
Stockholm School of Economics (2)
Mid Sweden University (2)
Södertörn University (2)
Swedish Museum of Natural History (2)
University West (1)
Mälardalen University (1)
University of Skövde (1)
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Language
English (766)
Undefined language (3)
Swedish (1)
Research subject (UKÄ/SCB)
Natural sciences (417)
Medical and Health Sciences (138)
Social Sciences (18)
Engineering and Technology (14)
Agricultural Sciences (9)

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