SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Wu HH) "

Sökning: WFRF:(Wu HH)

  • Resultat 31-40 av 77
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
31.
  •  
32.
  • Do, DV, et al. (författare)
  • A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo
  • 2013
  • Ingår i: Genes & development. - : Cold Spring Harbor Laboratory. - 1549-5477 .- 0890-9369. ; 27:12, s. 1378-1390
  • Tidskriftsartikel (refereegranskat)abstract
    • Although it is known that OCT4–NANOG are required for maintenance of pluripotent cells in vitro, the upstream signals that regulate this circuit during early development in vivo have not been identified. Here we demonstrate, for the first time, signal transducers and activators of transcription 3 (STAT3)-dependent regulation of the OCT4–NANOG circuitry necessary to maintain the pluripotent inner cell mass (ICM), the source of in vitro-derived embryonic stem cells (ESCs). We show that STAT3 is highly expressed in mouse oocytes and becomes phosphorylated and translocates to the nucleus in the four-cell and later stage embryos. Using leukemia inhibitory factor (Lif)-null embryos, we found that STAT3 phosphorylation is dependent on LIF in four-cell stage embryos. In blastocysts, interleukin 6 (IL-6) acts in an autocrine fashion to ensure STAT3 phosphorylation, mediated by janus kinase 1 (JAK1), a LIF- and IL-6-dependent kinase. Using genetically engineered mouse strains to eliminate Stat3 in oocytes and embryos, we firmly establish that STAT3 is essential for maintenance of ICM lineages but not for ICM and trophectoderm formation. Indeed, STAT3 directly binds to the Oct4 and Nanog distal enhancers, modulating their expression to maintain pluripotency of mouse embryonic and induced pluripotent stem cells. These results provide a novel genetic model of cell fate determination operating through STAT3 in the preimplantation embryo and pluripotent stem cells in vivo.
  •  
33.
  •  
34.
  •  
35.
  •  
36.
  •  
37.
  • Faure, L, et al. (författare)
  • Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates
  • 2020
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 4175-
  • Tidskriftsartikel (refereegranskat)abstract
    • Somatic sensation is defined by the existence of a diversity of primary sensory neurons with unique biological features and response profiles to external and internal stimuli. However, there is no coherent picture about how this diversity of cell states is transcriptionally generated. Here, we use deep single cell analysis to resolve fate splits and molecular biasing processes during sensory neurogenesis in mice. Our results identify a complex series of successive and specific transcriptional changes in post-mitotic neurons that delineate hierarchical regulatory states leading to the generation of the main sensory neuron classes. In addition, our analysis identifies previously undetected early gene modules expressed long before fate determination although being clearly associated with defined sensory subtypes. Overall, the early diversity of sensory neurons is generated through successive bi-potential intermediates in which synchronization of relevant gene modules and concurrent repression of competing fate programs precede cell fate stabilization and final commitment.
  •  
38.
  •  
39.
  •  
40.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 31-40 av 77
Typ av publikation
tidskriftsartikel (71)
konferensbidrag (2)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (68)
övrigt vetenskapligt/konstnärligt (6)
Författare/redaktör
Jonas, JB (20)
Sepanlou, SG (18)
Farzadfar, F (17)
Khader, YS (17)
Panda-Jonas, S (17)
Gupta, R. (16)
visa fler...
Brenner, H (16)
Malekzadeh, R (16)
Topor-Madry, R (16)
Djalalinia, S (15)
Khan, M (15)
Khang, YH (15)
Lotufo, PA (15)
Shiri, R (15)
Diaz, A. (14)
Banach, M (14)
Silva, DAS (14)
Gudnason, V (14)
Ikram, MA (14)
Gill, TK (13)
Mohammadifard, N (13)
Sarrafzadegan, N (13)
Shibuya, K (13)
Guo, Y (12)
Evans, A. (12)
Giampaoli, S (12)
Ikeda, N (12)
Musa, KI (12)
Nagel, G (12)
Pandey, A (12)
Pourshams, A (12)
Wojtyniak, B (12)
Wu, SL (12)
Amouyel, P (12)
Rahman, M (12)
Zhou, B. (11)
Kim, J. (11)
Aryal, KK (11)
Davletov, K (11)
Islam, M (11)
Islam, SMS (11)
Joukar, F (11)
Ostojic, SM (11)
Schutte, AE (11)
Sobngwi, E (11)
Wang, Q. (11)
Tzourio, C (11)
Cooper, C. (11)
Lehtimaki, T. (11)
He, J (11)
visa färre...
Lärosäte
Karolinska Institutet (73)
Uppsala universitet (21)
Lunds universitet (12)
Göteborgs universitet (11)
Umeå universitet (11)
Högskolan Dalarna (9)
visa fler...
Högskolan i Skövde (5)
Kungliga Tekniska Högskolan (3)
Stockholms universitet (3)
Chalmers tekniska högskola (2)
Linköpings universitet (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (77)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (30)
Naturvetenskap (7)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy