SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Yu JC) "

Sökning: WFRF:(Yu JC)

  • Resultat 61-70 av 131
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
61.
  •  
62.
  •  
63.
  •  
64.
  •  
65.
  •  
66.
  •  
67.
  •  
68.
  •  
69.
  • Callaway, EM, et al. (författare)
  • A multimodal cell census and atlas of the mammalian primary motor cortex
  • 2021
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 598:7879, s. 86-102
  • Tidskriftsartikel (refereegranskat)abstract
    • Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input–output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization1–5. First, our study reveals a unified molecular genetic landscape of cortical cell types that integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a consensus taxonomy of transcriptomic types and their hierarchical organization that is conserved from mouse to marmoset and human. Third, in situ single-cell transcriptomics provides a spatially resolved cell-type atlas of the motor cortex. Fourth, cross-modal analysis provides compelling evidence for the transcriptomic, epigenomic and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types. We further present an extensive genetic toolset for targeting glutamatergic neuron types towards linking their molecular and developmental identity to their circuit function. Together, our results establish a unifying and mechanistic framework of neuronal cell-type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.
  •  
70.
  • Chen, XD, et al. (författare)
  • Non-invasive early detection of cancer four years before conventional diagnosis using a blood test
  • 2020
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 3475-
  • Tidskriftsartikel (refereegranskat)abstract
    • Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and were then monitored for cancer occurrence. Here we report the preliminary results of PanSeer, a noninvasive blood test based on circulating tumor DNA methylation, on TZL plasma samples from 605 asymptomatic individuals, 191 of whom were later diagnosed with stomach, esophageal, colorectal, lung or liver cancer within four years of blood draw. We also assay plasma samples from an additional 223 cancer patients, plus 200 primary tumor and normal tissues. We show that PanSeer detects five common types of cancer in 88% (95% CI: 80–93%) of post-diagnosis patients with a specificity of 96% (95% CI: 93–98%), We also demonstrate that PanSeer detects cancer in 95% (95% CI: 89–98%) of asymptomatic individuals who were later diagnosed, though future longitudinal studies are required to confirm this result. These results demonstrate that cancer can be non-invasively detected up to four years before current standard of care.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 61-70 av 131
Typ av publikation
tidskriftsartikel (129)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (123)
övrigt vetenskapligt/konstnärligt (7)
Författare/redaktör
Brenner, H (42)
Jonas, JB (40)
Mokdad, AH (34)
Monasta, L (33)
Yonemoto, N (33)
Yu, CH (32)
visa fler...
Fischer, F (31)
Mendoza, W (31)
Miller, TR (31)
Ronfani, L (31)
Hay, SI (30)
Nangia, V (30)
Singh, JA (30)
Shaikh, MA (29)
Violante, FS (29)
Murray, CJL (29)
Yu, JC (29)
Bennett, DA (28)
Hamadeh, RR (28)
Khader, YS (28)
Mohammed, S (28)
Sepanlou, SG (28)
Younis, MZ (28)
Hall, P (28)
Shen, CY (28)
Gupta, R. (27)
Dandona, R (27)
Farzadfar, F (27)
Liu, SW (27)
Majeed, A (27)
Samy, AM (27)
Schwebel, DC (27)
Shiri, R (27)
Tabares-Seisdedos, R (27)
Mannermaa, A (27)
Chang-Claude, J (27)
Alvis-Guzman, N (26)
Dandona, L (26)
Fereshtehnejad, SM (26)
Hosseinzadeh, M (26)
Islam, SMS (26)
Kim, YJ (26)
Kumar, GA (26)
Meretoja, TJ (26)
Oh, IH (26)
Olagunju, AT (26)
Radfar, A (26)
Tran, BX (26)
Waheed, Y (26)
Hopper, JL (26)
visa färre...
Lärosäte
Karolinska Institutet (129)
Uppsala universitet (51)
Lunds universitet (33)
Högskolan Dalarna (22)
Göteborgs universitet (17)
Umeå universitet (11)
visa fler...
Stockholms universitet (7)
Chalmers tekniska högskola (4)
Linköpings universitet (2)
Örebro universitet (1)
Jönköping University (1)
Handelshögskolan i Stockholm (1)
Södertörns högskola (1)
Högskolan i Skövde (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (131)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (72)
Naturvetenskap (8)
Samhällsvetenskap (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy