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Träfflista för sökning "WFRF:(Zhao SC) "

Search: WFRF:(Zhao SC)

  • Result 51-60 of 104
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  • Graslund, S, et al. (author)
  • Protein production and purification
  • 2008
  • In: Nature methods. - : Springer Science and Business Media LLC. - 1548-7105 .- 1548-7091. ; 5:2, s. 135-146
  • Journal article (peer-reviewed)
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  • Hillmer, AM, et al. (author)
  • Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes
  • 2011
  • In: Genome research. - : Cold Spring Harbor Laboratory. - 1549-5469 .- 1088-9051. ; 21:5, s. 665-675
  • Journal article (peer-reviewed)abstract
    • Somatic genome rearrangements are thought to play important roles in cancer development. We optimized a long-span paired-end-tag (PET) sequencing approach using 10-Kb genomic DNA inserts to study human genome structural variations (SVs). The use of a 10-Kb insert size allows the identification of breakpoints within repetitive or homology-containing regions of a few kilobases in size and results in a higher physical coverage compared with small insert libraries with the same sequencing effort. We have applied this approach to comprehensively characterize the SVs of 15 cancer and two noncancer genomes and used a filtering approach to strongly enrich for somatic SVs in the cancer genomes. Our analyses revealed that most inversions, deletions, and insertions are germ-line SVs, whereas tandem duplications, unpaired inversions, interchromosomal translocations, and complex rearrangements are over-represented among somatic rearrangements in cancer genomes. We demonstrate that the quantitative and connective nature of DNA–PET data is precise in delineating the genealogy of complex rearrangement events, we observe signatures that are compatible with breakage-fusion-bridge cycles, and we discover that large duplications are among the initial rearrangements that trigger genome instability for extensive amplification in epithelial cancers.
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  • Result 51-60 of 104
Type of publication
journal article (97)
conference paper (2)
research review (1)
Type of content
peer-reviewed (93)
other academic/artistic (7)
Author/Editor
Brenner, H (26)
Jonas, JB (26)
Gudnason, V (24)
Ikram, MA (22)
Lehtimaki, T. (22)
Gupta, R. (21)
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Vollenweider, P. (21)
Liu, J. (20)
Kim, J. (20)
Mahajan, A. (20)
Cheng, CY (20)
Peters, A (19)
Khan, M (19)
Pandey, A (19)
Jukema, JW (19)
Wong, TY (19)
Diaz, A. (18)
Sepanlou, SG (18)
Topor-Madry, R (18)
Tuomilehto, J. (18)
Joshi, P. (18)
Evans, A. (17)
Das, S. (17)
Lotufo, PA (17)
Guo, Y (16)
Liu, SW (16)
Malekzadeh, R (16)
Panda-Jonas, S (16)
Shibuya, K (16)
Shiri, R (16)
Lee, J. (16)
Yang, J. (16)
Wang, Q. (16)
Elliott, P (16)
He, J (16)
Linneberg, A. (16)
Sundstrom, J (16)
Li, Y. (15)
Zhang, Y. (15)
Kumar, A. (15)
Khan, A. (15)
Djalalinia, S (15)
Farzadfar, F (15)
Mohammadifard, N (15)
Schutte, AE (15)
Silva, DAS (15)
Sorensen, TIA (15)
Taylor, A (15)
Khaw, KT (15)
Dorobantu, M (15)
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University
Karolinska Institutet (101)
Uppsala University (46)
Lund University (27)
University of Gothenburg (21)
Umeå University (15)
Högskolan Dalarna (10)
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Linköping University (5)
University of Skövde (5)
Stockholm University (2)
Örebro University (2)
Kristianstad University College (1)
Royal Institute of Technology (1)
Stockholm School of Economics (1)
Swedish University of Agricultural Sciences (1)
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Language
English (104)
Research subject (UKÄ/SCB)
Medical and Health Sciences (58)
Natural sciences (5)
Social Sciences (2)
Humanities (1)

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