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Sökning: tom karlsson

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  • Santti, Kirsi, et al. (författare)
  • High cyclin A expression, but not Ki67, is associated with early recurrence in desmoid tumors
  • 2018
  • Ingår i: Journal of Surgical Oncology. - : Wiley-Interscience Publishers. - 0022-4790 .- 1096-9098. ; 118:1, s. 192-198
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND AND OBJECTIVES: Desmoid tumors are soft-tissue tumors originating from myofibroblasts with a tendency to recur after surgery. High expression of proliferation markers is associated with shortened progression-free and/or overall survival in many neoplasms, including soft-tissue sarcomas. We investigated the prognostic role of cyclin A and Ki67 in desmoid tumors by immunohistochemistry.METHODS: The study included 76 patients with desmoid tumor operated at Helsinki University Hospital between 1987 and 2011. A tissue micro array (TMA) was constructed and the TMA sections were immunostained with cyclin A and Ki67 antibodies. A computer-assisted image analysis was performed.RESULTS: Cyclin A expression was evaluable in 74 and Ki67 in 70 patients. Cyclin A immunopositivity varied from 0% to 9.9%, with a mean of 1.9%. Cyclin A expression correlated significantly with Ki67. Cyclin A expression was associated with recurrence-free survival (HR 1.9, 95% CI = 1.1-3.2, P = .02), as were positive margin (HR 6.0, 95% CI = 1.6-22.5, P = .008) and extremity location (HR 5.3, 95% CI = 1.7-16.8, P = 0.005). Ki67 immunopositivity varied from 0.33% to 13.8%, with a mean of 4.6%, but had no significant prognostic impact (HR 1.1, P = .2).CONCLUSIONS: Our study indicates that cyclin A may be a new prognostic biomarker in surgically treated desmoid tumors.
  • Sarwar, Nadeem, et al. (författare)
  • Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies
  • 2012
  • Ingår i: The Lancet. - New York, NY, USA : Elsevier. - 1474-547X .- 0140-6736. ; 379:9822, s. 1205-1213
  • Tidskriftsartikel (refereegranskat)abstract
    • Background Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling. Methods In a collaborative meta-analysis, we studied Asp358Ala (rs2228145) in IL6R in relation to a panel of conventional risk factors and inflammation biomarkers in 125 222 participants. We also compared the frequency of Asp358Ala in 51 441 patients with coronary heart disease and in 136 226 controls. To gain insight into possible mechanisms, we assessed Asp358Ala in relation to localised gene expression and to postlipopolysaccharide stimulation of interleukin 6. Findings The minor allele frequency of Asp358Ala was 39%. Asp358Ala was not associated with lipid concentrations, blood pressure, adiposity, dysglycaemia, or smoking (p value for association per minor allele >= 0.04 for each). By contrast, for every copy of 358Ala inherited, mean concentration of IL6R increased by 34.3% (95% CI 30.4-38.2) and of interleukin 6 by 14.6% (10.7-18.4), and mean concentration of C-reactive protein was reduced by 7.5% (5.9-9.1) and of fibrinogen by 1.0% (0.7-1.3). For every copy of 358Ala inherited, risk of coronary heart disease was reduced by 3.4% (1.8-5.0). Asp358Ala was not related to IL6R mRNA levels or interleukin-6 production in monocytes. Interpretation Large-scale human genetic and biomarker data are consistent with a causal association between IL6R-related pathways and coronary heart disease.
  • Sehlstedt-Persson, Margot, et al. (författare)
  • Mold growth on sapwood boards exposed outdoors : the impact of wood drying
  • 2011
  • Ingår i: Forest products journal. - 0015-7473. ; 61:2, s. 170-179
  • Tidskriftsartikel (refereegranskat)abstract
    • Mold growth on dried Norway spruce and Scots pine sapwood boards was investigated in an accelerated outdoor field test for 96 days. The boards were dried using three different methods of stacking: single stacking, double stacking with the sapwood sides in each pair facing toward each other, and double stacking with sapwood sides facing outward. Drying was performed at three temperatures: 25ºC, corresponding to air drying, and kiln drying at 70ºC and 110ºC. The degree of mold growth was visually assessed on both sides of each board. On average, pine boards showed a higher level of mold growth than the spruce boards. The highest average level of mold growth was found on the boards kiln dried at 708C, whereas the air-dried boards and the boards kiln dried at 110ºC showed considerably less mold growth. Stacking the boards during drying had a large impact on mold susceptibility of the sapwood. This study confirmed that, during the drying process, it is possible to direct the migration of nutrients in sapwood toward one chosen side of each board by double stacking; the opposite side leaches out, which has a great impact on surface mold growth. Chemical analyses of monosaccharide sugar gradients beneath the boards’ surfaces confirmed the results.
  • Søvik, Torgeir T, et al. (författare)
  • Gastrointestinal function and eating behavior after gastric bypass and duodenal switch.
  • 2013
  • Ingår i: Surgery for obesity and related diseases. - : ELSEVIER SCIENCE INC. - 1878-7533 .- 1550-7289. ; 9:5, s. 641-647
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Duodenal switch provides greater weight loss than gastric bypass in severely obese patients; however, comparative data on the changes in gastrointestinal symptoms, bowel function, eating behavior, dietary intake, and psychosocial functioning are limited. METHODS: The setting for the present study was 2 university hospitals in Norway and Sweden. Participants with a body mass index of 50-60 kg/m(2) were randomly assigned to gastric bypass (n = 31) or duodenal switch (n = 29) and followed up for 2 years. Of the 60 patients, 97% completed the study. Their mean weight decreased by 31.2% after gastric bypass and 44.8% after duodenal switch. At inclusion and 1 and 2 years of follow-up, the participants completed the Gastrointestinal Symptom Rating Scale, a bowel function questionnaire, the Three-Factor Eating Questionnaire-R21, a 4-day food record, and the Obesity-related Problems scale. RESULTS: Compared with the gastric bypass group, the duodenal switch group reported more symptoms of diarrhea (P = .0002), a greater mean number of daytime defecations (P = .007), and more anal leakage of stool (50% versus 18% of participants, respectively; P = .015) after 2 years. The scores for uncontrolled and emotional eating were significantly and similarly reduced after both operations. The mean total caloric intake and intake of fat and carbohydrates were significantly reduced in both groups. Protein intake was significantly reduced only after gastric bypass (P = .008, between-group comparison). Psychosocial function was significantly improved after both operations (P = .23, between the 2 groups). CONCLUSION: Gastrointestinal side effects and anal leakage of stool were more pronounced after duodenal switch than after gastric bypass. Both procedures led to reduced uncontrolled and emotional eating, reduced caloric intake, and improved psychosocial functioning.
  • Åstrand, Per, 1935-, et al. (författare)
  • Nonsubmerged and submerged implants in the treatment of the partially edentulous maxilla.
  • 2002
  • Ingår i: Clinical Implant Dentistry and Related Research. - 1523-0899 .- 1708-8208. ; 4:3, s. 115-127
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Dental implants vary in design and surfaces. In addition, different surgical techniques have been used for implant insertion. The ITI Dental Implant System (Straumann AG, Waldenburg, Switzerland) has always required a one-stage technique, whereas the Brσnemark System (Nobel Biocare AB, Gothenburg, Sweden) requires a two-stage technique. PURPOSE: The aim of this study is to compare the outcome of fixed partial bridges in the maxilla supported by both ITI and Brσnemark implants in a split-mouth design. MATERIALS AND METHODS: Twenty-eight patients with a residual anterior dentition in the maxilla were included in this split-mouth study. The Brσnemark implants were used on one side and the ITI implants on the other side of the residual dentition according to a randomization procedure. A blocking size of four was used, giving equal probability of placing ITI or Brσnemark implants in the right or left side of the jaw. The surgical and prosthetic procedures followed the guidelines given by the manufacturers. The prosthetic treatment with the two-implant systems was performed at the same time, and for that reason the healing period was 6 months for both systems. The observation period for all patients was 1 year after loading. RESULTS: Two Brσnemark implants (in one patient) were lost before loading, and one ITI implant was lost 1 year after loading. There was no significant difference in survival rate. Radiographic examination of the bone level was performed at the time of delivery of the bridge and after 1 year. The mean marginal bone level at baseline was situated 1.9 mm from the reference point for the Brσnemark implants and 1.5 mm for the ITI implants. With regard to the insertion depth used, these bone levels indicate that bone loss had taken place before baseline. However, between baseline and the 1-year examination, there was no significant change of the marginal bone (0.2 +/- 0.08 mm at the Brσnemark implants and 0.1 +/- 0.11 mm at the ITI implants). The difference between results with the two implants was not statistically significant. Crater-form bone destructions were seen at some ITI implants, indicating periimplantitis. However, at only two implants were there clinical signs of periimplantitis. CONCLUSIONS: No significant difference in survival rate or in marginal bone change could be demonstrated between the two systems. At some ITI implants (18%), crater-form bone loss was observed.
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