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  • Elgqvist, Jörgen, 1963, et al. (författare)
  • Therapeutic efficacy and tumor dose estimations in radioimmunotherapy of intraperitoneally growing OVCAR-3 cells in nude mice with (211)At-labeled monoclonal antibody MX35
  • 2005
  • Ingår i: J Nucl Med. - 0161-5505. ; 46:11, s. 1907-15
  • Tidskriftsartikel (refereegranskat)abstract
    • The purpose of this study was to investigate the therapeutic efficacy of-and to estimate the absorbed dose to-tumor cells from radioimmunotherapy (RIT) in an ovarian cancer model using the alpha-particle-emitting nuclide (211)At labeled to monoclonal antibody (mAb) MX35. Previous studies on mAb MOv18 did not allow for dosimetry because of antigen shedding in vitro. METHODS: Five-week-old female nude BALB/c nu/nu mice were inoculated intraperitoneally with 1 x 10(7) cells of the human tumor cell line OVCAR-3. Three weeks later, the animals were given approximately 400, 800, or 1,200 kBq of (211)At-labeled mAb MX35 intraperitoneally. As controls, one group of animals was injected with unlabeled mAb and another group was injected with phosphate-buffered saline (PBS). Another group was given approximately 400 kBq of (211)At labeled to the previously investigated mAb MOv18 for efficacy comparison. Two months after treatment, the animals were sacrificed and the presence of macroscopic and microscopic tumors, as well as ascites, was determined. The absorbed dose to tumor cells on the peritoneal surface was estimated in terms of the sum of a specific and a nonspecific contribution. The specific contribution, arising from mAbs binding to the antigenic sites on the cell membrane, was calculated using a dynamic compartment model developed in-house and Monte Carlo software. The model used as input values the number of mAbs injected into the abdominal cavity, N(mAb), the specific activity, A(sp), the association rate constant, k(on), and the maximal number of mAbs bound per cell, B(max)-all determined by in vitro experiments. This specific component of the absorbed dose was calculated for assumed cell cluster sizes with radii of 25, 50, and 100 microm. The nonspecific contribution to the absorbed dose was derived from unbound mAbs freely circulating in the abdominal cavity, also using the Monte Carlo software. RESULTS: In the control groups given unlabeled MX35 or PBS, all 18 animals had ascites, 6 of 9 animals in each group had macroscopic tumors, and all animals had microscopic growth. In the 3 groups given different amounts of (211)At-MX35, only 3 of 25 animals developed ascites. None of these animals had any sign of macroscopic tumors, but 8 had microscopic growth. In the group given (211)At-MOv18, no animals had ascites or macroscopic tumors, but 3 of 10 animals had microscopic tumors. After injecting 400 kBq of (211)At-MX35, the absorbed dose due to specific binding, for a cell cluster with a radius of 50 microm, ranged from 413 to 223 Gy between 0- and 45-microm distance from the cluster center, assuming a homogeneous distribution of (211)At-MX35 in the cluster. The contribution from unbound (211)At-MX35 and (211)At-MX35 only distributed on the cluster surface, for this cluster size, ranged from 7 to 14 Gy and from 29 to 94 Gy, between 0- and 45-microm distance from the cluster center, respectively. The calculated total absorbed doses are in a clinically relevant range and were effective as verified in the nude mice with subclinical intraperitoneal growth of OVCAR-3 cells. CONCLUSION: (211)At-MX35 injected intraperitoneally exhibits a high efficacy when treating micrometastatic growth of the ovarian cancer cell line OVCAR-3 on the peritoneum of nude mice.
  • Firtin, Cemil Eren, et al. (författare)
  • Calculation, justification, and medical profession: Introduction of performance appraisals and pecuniary incentives within an emergency unit
  • 2019
  • Ingår i: The Centre for Global Human Resource Management, International Interdisciplinary Conference on HRM, 03-05 April 2019, Gothenburg.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • In this article, we address the issues of calculation and economization within contemporary public organizations. We address issues of how choices of organizing emergency health care have been affected by a production of calculation. More specifically, we pay specific attention to how the use of performance appraisals, in terms of calculations and valuations, has become important components in the construction of pecuniary incentives for individual professionals within healthcare organizations. Drawing on empirical data from 12 in-depth interviews at three different emergency health care sites, the analysis reveals how calculation and accounting as a performative act shapes professional work. This article contributes to the growing literature focusing on accountingization by showing how the calculations enable the meet between accounting and medical profession and demonstrating the performative consequences of accounting on the medical work.
  • Firtin, Cemil Eren, et al. (författare)
  • (Re)descriptions of medical professional work: exploring accounting as a performative device within an emergency unit health-care context : Exploring accounting as a performative device
  • 2020
  • Ingår i: Journal of Public Budgeting, Accounting and Financial Management. - 1096-3367. ; 32:2, s. 159-176
  • Tidskriftsartikel (refereegranskat)abstract
    • Abstract Purpose This article addresses issues of calculation and economization in contemporary public organizations. In particular, it investigates how choices of organizing emergency health-care have been affected by accounting as a performative device. Special attention has been paid to how accounting brings about performative consequences in shaping the medical profession and its context. Design/methodology/approach The article employs qualitative research methods and draws its analysis on empirical data from in-depth interviews at an emergency health-care unit in Sweden. Findings It is demonstrated how accounting, in the form of calculations of treatment time and number of patients, enables performative consequences for medical professional work. It is also demonstrated how the use of accounting engages (re)descriptions of practices and roles, creates accounts of patients, and helps to sustain such (re)descriptions. Accounting terms (such as efficiency and control) have been reframed into medical terminology (such as health-care quality and security), ensuring and retaining (re)described medical professional work in terms of practices and emerging roles. Originality/value This article contributes to (1) the literature on accounting practices within health-care contexts by demonstrating a case where the accounting ideas and practices of medical professionals are coexistent and interwoven and (2) the increasing body of literature focusing on accountingization by showing how emerging calculative technologies carry performative power over medical professional work through formative (re)descriptions.
  • Funck, Elin, 1979, et al. (författare)
  • 25 years of studying New Public Management: Accomplishments and limitations
  • 2018
  • Ingår i: The 22nd Annual International Research Society for Public Management (IRSPM) Conference. Edinburgh, Scotland: 11-13 April.
  • Konferensbidrag (övrigt vetenskapligt)abstract
    • 25 years ago, Christopher Hood made a substantial contribution to public administration research in his formulation of the concept New Public Management (NPM). In many ways, his article can be understood as an enabler of research focusing on public sector reforms. To this day, numerous articles and books have been published, discussing the concept itself and the empirical phenomenon. In celebration of this anniversary, this article revisits the current knowledge through a systematic literature review of 299 articles published between 1991 and 2016. This approach enables a meta-analysis of research published in five top-ranked international public administration journals. We identify four important themes as emerging from our review; (i) a reform with a vague intention, (ii) the limping concept, (iii) the one- sided perspective and (iv) NPM as the new norm. An important effect of this is that Hoods framework may have been curtailed, leading to a distorted knowledge-base when it comes to future studies.
  • Funck, Elin, et al. (författare)
  • Fyra starka trender efter NPM
  • 2019
  • Ingår i: Kommunal ekonomi. - : Föreningen Sveriges Kommunalekonomer. - 0282-0099. ; :3
  • Tidskriftsartikel (populärvet., debatt m.m.)
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