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A link between sero...
A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety
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- Furmark, Tomas (author)
- Uppsala universitet,Institutionen för psykologi
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- Appel, Lieuwe (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Enheten för nuklearmedicin och PET,Uppsala Imanet, GE Healthcare, Uppsala, Sweden
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- Henningsson, Susanne, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Department ofPharmacology, Göteborg University, Göteborg, Sweden
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- Åhs, Fredrik (author)
- Uppsala universitet,Institutionen för psykologi
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- Faria, Vanda (author)
- Uppsala universitet,Institutionen för psykologi
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- Linnman, Clas (author)
- Uppsala universitet,Institutionen för psykologi
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- Pissiota, Anna (author)
- Uppsala universitet,Institutionen för psykologi
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- Frans, Örjan (author)
- Uppsala universitet,Institutionen för psykologi
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- Bani, Massimo (author)
- GlaxoSmithKline, Medicine Research Centre, Verona, Italy
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- Bettica, Paolo (author)
- GlaxoSmithKline, Medicine Research Centre, Verona, Italy
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- Pich, Emilio Merlo (author)
- GlaxoSmithKline, Medicine Research Centre, Verona, Italy
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- Jacobsson, Eva (author)
- Quintiles AB Phase IServices, Uppsala, Sweden
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- Wahlstedt, Kurt (author)
- Quintiles AB Phase IServices, Uppsala, Sweden
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- Oreland, Lars (author)
- Uppsala universitet,Farmakologi,Department of Neuroscience, Pharmacology, Uppsala University, Uppsala, Sweden
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- Långström, Bengt (author)
- Uppsala Imanet, GE Healthcare, Uppsala, Sweden; Department ofBiochemistry and Organic Chemistry, Uppsala University, Uppsala, Sweden
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- Eriksson, Elias, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology,Department ofPharmacology, Göteborg University, Göteborg, Sweden
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- Fredrikson, Mats (author)
- Uppsala universitet,Institutionen för psykologi
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: Journal of Neuroscience. - 0270-6474 .- 1529-2401. ; 28:49, s. 13066-74
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Abstract
Subject headings
Close
- Placebo may yield beneficial effects that are indistinguishable from those of active medication, but the factors underlying proneness to respond to placebo are widely unknown. Here, we used functional neuroimaging to examine neural correlates of anxiety reduction resulting from sustained placebo treatment under randomized double-blind conditions, in patients with social anxiety disorder. Brain activity was assessed during a stressful public speaking task by means of positron emission tomography before and after an 8 week treatment period. Patients were genotyped with respect to the serotonin transporter-linked polymorphic region (5-HTTLPR) and the G-703T polymorphism in the tryptophan hydroxylase-2 (TPH2) gene promoter. Results showed that placebo response was accompanied by reduced stress-related activity in the amygdala, a brain region crucial for emotional processing. However, attenuated amygdala activity was demonstrable only in subjects who were homozygous for the long allele of the 5-HTTLPR or the G variant of the TPH2 G-703T polymorphism, and not in carriers of short or T alleles. Moreover, the TPH2 polymorphism was a significant predictor of clinical placebo response, homozygosity for the G allele being associated with greater improvement in anxiety symptoms. Path analysis supported that the genetic effect on symptomatic improvement with placebo is mediated by its effect on amygdala activity. Hence, our study shows, for the first time, evidence of a link between genetically controlled serotonergic modulation of amygdala activity and placebo-induced anxiety relief.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- placebo
- genes
- phobia
- serotonin
- brain
- functional neuroimaging
- PHARMACY
- FARMACI
- Serotonin-related gene
- amygdala activity
- social anxiety
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Furmark, Tomas
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Appel, Lieuwe
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Henningsson, Sus ...
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Åhs, Fredrik
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Faria, Vanda
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Linnman, Clas
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show more...
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Pissiota, Anna
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Frans, Örjan
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Bani, Massimo
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Bettica, Paolo
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Pich, Emilio Mer ...
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Jacobsson, Eva
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Wahlstedt, Kurt
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Oreland, Lars
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Långström, Bengt
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Eriksson, Elias, ...
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Fredrikson, Mats
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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and Psychology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
- Articles in the publication
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Journal of Neuro ...
- By the university
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Uppsala University
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University of Gothenburg
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Mid Sweden University