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Effect of industria...
Effect of industrially produced trans fat on markers of systemic inflammation : evidence from a randomized trial in women
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Bendsen, Nathalie T. (författare)
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Stender, Steen (författare)
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Szecsi, Pal B. (författare)
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Pedersen, Steen B. (författare)
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- Basu, Samar (författare)
- Uppsala universitet,Oxidativ stress och inflammation
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Hellgren, Lars I. (författare)
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Newman, John W. (författare)
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Larsen, Thomas M. (författare)
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Haugaard, Steen B. (författare)
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Astrup, Arne (författare)
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(creator_code:org_t)
- 2011
- 2011
- Engelska.
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Ingår i: Journal of Lipid Research. - 0022-2275 .- 1539-7262. ; 52:10, s. 1821-1828
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated with systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. Therefore, we conducted a 16 week double-blind parallel intervention study with the objective to examine the effect of IP-TFA intake on bio-markers of inflammation, oxidative stress, and endothelial dysfunction. Fifty-two healthy overweight postmenopausal women (49 completers) were randomly assigned to receive either partially hydrogenated soybean oil (15.7 g/day IP-TFA) or control oil without IP-TFA. After 16 weeks, IP-TFA intake increased baseline-adjusted serum tumor necrosis factor (TNF) alpha by 12% [95% confidence interval (CI): 5-20; P = 0.002] more in the IP-TFA group compared with controls. Plasma soluble TNF receptors 1 and 2 were also increased by IP-TFA [155 pg/ml (CI: 63-247); P < 0.001 and 480 pg/ml (CI: 72-887); P = 0.02, respectively]. Serum C-reactive protein, interleukin (IL) 6 and adiponectin and subcutaneous abdominal adipose tissue mRNA expression of IL6, IL8, TNF alpha, and adiponectin as well as ceramide content were not affected by IP-TFA, nor was urinary 8-iso-prostaglandin-F(2 alpha). In conclusion, this dietary trial indicates that the mechanisms linking dietary IP-TFA to cardiovascular disease may involve activation of the TNF alpha system.
Nyckelord
- fatty acids
- dietary intervention
- oxidative stress
- ceramide
- subcutaneous adipose tissue
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Bendsen, Nathali ...
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Stender, Steen
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Szecsi, Pal B.
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Pedersen, Steen ...
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Basu, Samar
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Hellgren, Lars I ...
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visa fler...
-
Newman, John W.
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Larsen, Thomas M ...
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Haugaard, Steen ...
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Astrup, Arne
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visa färre...
- Artiklar i publikationen
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Journal of Lipid ...
- Av lärosätet
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Uppsala universitet