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A Stronger Innate I...
A Stronger Innate Immune Response During Hyperacute HIV-1 Infection is associated with ACUTE retroviral syndrome
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- Hassan, Amin S (author)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,Kenya Medical Research Institute (KEMRI)
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- Hare, Jonathan (author)
- IAVI Human Immunology Laboratory (HIL)
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- Gounder, Kamini (author)
- University of KwaZulu-Natal
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- Nazziwa, Jamirah (author)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups
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- Karlson, Sara (author)
- Lund University,Lunds universitet,Avdelningen för medicinsk mikrobiologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,HIV-1 och HIV-2 värd interaktioner,Forskargrupper vid Lunds universitet,Division of Medical Microbiology,Department of Laboratory Medicine,Faculty of Medicine,HIV-1 and HIV-2 host interactions,Lund University Research Groups
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- Olsson, Linnéa (author)
- Helsingborg Hospital
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Streatfield, Claire (author)
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Kamali, Anatoli (author)
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Karita, Etienne (author)
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Kilembe, William (author)
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Price, Matt A (author)
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- Borrow, Persephone (author)
- University of Oxford
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- Björkman, Per (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups
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- Kaleebu, Pontiano (author)
- London School of Hygiene and Tropical Medicine
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- Allen, Susan (author)
- Emory University
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- Hunter, Eric (author)
- Emory University
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- Ndung'u, Thumbi (author)
- University of KwaZulu-Natal
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Gilmour, Jill (author)
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- Rowland-Jones, Sarah (author)
- University of Oxford
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- Esbjörnsson, Joakim (author)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,University of Oxford
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- Sanders, Eduard J (author)
- University of Oxford
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(creator_code:org_t)
- 2021-02-15
- 2021
- English.
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In: Clinical Infectious Diseases. - : Oxford University Press (OUP). - 1537-6591 .- 1058-4838. ; 73:5, s. 832-841
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Abstract
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- BACKGROUND: Acute retroviral syndrome (ARS) is associated with HIV-1 subtype and disease progression, but the underlying immunopathological pathways are poorly understood. We aimed to elucidate associations between innate immune responses during hyperacute HIV-1 infection (hAHI) and ARS.METHODS: Plasma samples obtained from volunteers (≥18.0 years) before and during hAHI, defined as HIV-1 antibody negative and RNA or p24 antigen positive from Kenya, Rwanda, Uganda, Zambia and Sweden were analysed. Forty soluble innate immune markers were measured using multiplexed assays. Immune responses were differentiated into volunteers with stronger and comparatively weaker responses using principal component analysis. Presence or absence of ARS was defined based on eleven symptoms using latent class analysis. Logistic regression was used to determine associations between immune responses and ARS.RESULTS: Of 55 volunteers, 31 (56%) had ARS. Volunteers with stronger immune responses (n=36 [65%]) had increased odds of ARS which was independent of HIV-1 subtype, age, and risk group (adjusted odds ratio, 7.1 [95% CI: 1.7-28.8], p=0.003). IP-10 was fourteen-fold higher during hAHI, elevated in seven of the eleven symptoms, and independently associated with ARS. IP-10 threshold >466.0 pg/mL differentiated stronger immune responses with a sensitivity of 84.2% (95% CI: 60.4-96.6) and specificity of 100.0% (95% CI: 90.3-100.0).CONCLUSIONS: A stronger innate immune response during hAHI was associated with ARS. Plasma IP-10 may be a candidate biomarker of stronger innate immunity. Our findings provide further insights on innate immune responses in regulating ARS and may inform the design of vaccine candidates harnessing innate immunity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
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- By the author/editor
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Hassan, Amin S
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Hare, Jonathan
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Gounder, Kamini
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Nazziwa, Jamirah
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Karlson, Sara
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Olsson, Linnéa
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show more...
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Streatfield, Cla ...
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Kamali, Anatoli
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Karita, Etienne
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Kilembe, William
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Price, Matt A
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Borrow, Persepho ...
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Björkman, Per
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Kaleebu, Pontian ...
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Allen, Susan
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Hunter, Eric
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Ndung'u, Thumbi
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Gilmour, Jill
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Rowland-Jones, S ...
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Esbjörnsson, Joa ...
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Sanders, Eduard ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Clinical Infecti ...
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Lund University