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1.
  • Beahm, Brendan J, et al. (författare)
  • A visualizable chain-terminating inhibitor of glycosaminoglycan biosynthesis in developing zebrafish
  • 2014
  • Ingår i: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 53:13, s. 3347-3352
  • Tidskriftsartikel (refereegranskat)abstract
    • Heparan sulfate (HS) and chondroitin sulfate (CS) glycosaminoglycans (GAG) are proteoglycan-associated polysaccharides with essential functions in animals. They have been studied extensively by genetic manipulation of biosynthetic enzymes, but chemical tools for probing GAG function are limited. HS and CS possess a conserved xylose residue that links the polysaccharide chain to a protein backbone. Here we report that, in zebrafish embryos, the peptide-proximal xylose residue can be metabolically replaced with a chain-terminating 4-azido-4-deoxyxylose (4-XylAz) residue by administration of UDP-4-azido-4-deoxyxylose (UDP-4-XylAz). UDP-4-XylAz disrupted both HS and CS biosynthesis and caused developmental abnormalities reminiscent of GAG biosynthesis and laminin mutants. The azide substituent of protein-bound 4-XylAz allowed for rapid visualization of the organismal sites of chain termination in vivo through bioorthogonal reaction with fluorescent cyclooctyne probes. UDP-4-XylAz therefore complements genetic tools for studies of GAG function in zebrafish embryogenesis.
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4.
  • Li, Yunyao, et al. (författare)
  • Jennifer for COVID-19: An NLP-Powered Chatbot Built for the Peopleand by the People to Combat Misinformation
  • 2020
  • Ingår i: Proceedings of the 1st Workshop on NLP for COVID-19 at ACL 2020.
  • Konferensbidrag (refereegranskat)abstract
    • Just as SARS-CoV-2 continues to infect a growing number of people around the world, harmful misinformation about the outbreak also continues to spread. We designed and built Jennifer chatbot to provide easily accessible information from reliable resources to answer questions related to the current COVID-19 pandemic. It covers a wide variety of topics, from case statistics to best practices for disease prevention and management.
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