| 1. |
- Hansen, Kjetil Falkenberg, 1972-, et al.
(författare)
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A music puzzle game application for engaging in active listening
- 2012
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Ingår i: Proceedings of 97th Information Science and Music (SIGMUS) Research Conference. - Tokyo : Information Processing Society of Japan. ; , s. 1-4
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Konferensbidrag (refereegranskat)abstract
- In this paper we introduce an application for tablet devices with Android operating system called The Music Puzzle.This work is part of an ongoing projectcalled The Soundparkï¿œUsing modern smartphones to create interactive listening experiences for hearing impaired. In the Soundpark, we intend to provide different experimental applications for interacting with sound. The aim of the presented study was to create interactive and game-inspired listening experiences for persons with hearing impairmens (and possibly using hearing aids or having cochlea implants). Audio-based programs constitute a significant part of the Android market, but the scopes of existing applications are limited. Modern smart devices open up new possibilities both in terms of usingexternal information as input and providing real-time audio feedback to the user, and the Music Puzzle has a novel approach that explores the new possibilities.
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| 2. |
- Mulu, Berhanu, et al.
(författare)
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Simulation-based investigation of unsteady flow in near-hub region of a Kaplan Turbine with experimental comparison
- 2015
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Ingår i: Engineering Applications of Computational Fluid Mechanics. - : Informa UK Limited. - 1994-2060 .- 1997-003X. ; 9:1, s. 139-156
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Tidskriftsartikel (refereegranskat)abstract
- his paper presents a detailed comparison of steady and unsteady turbulent flow simulation results in the U9 Kaplan turbine draft tube with experimental velocity and pressure measurements. The computational flow domain includes the guide vanes, the runner and the draft tube. A number of turbulence models were studied, including the standard k-eps, RNG k-eps, SST and SST-SAS models. Prediction of the flow behavior in the conical section of the draft tube directly below the runner cone is very sensitive to the prediction of the separation point on the runner cone. The results demonstrate a significant increase in precision of the flow modeling in the runner cone region by using unsteady flow simulations compare to stage simulation. The prediction of the flow in the runner cone region, however, remains delicate, and no turbulence model could accurately predict the complex phenomena observed experimentally.
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| 3. |
- Tukiainen, Taru, et al.
(författare)
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Chromosome x-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.
- 2014
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Ingår i: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 10:2
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Tidskriftsartikel (refereegranskat)abstract
- The X chromosome (chrX) represents one potential source for the "missing heritability" for complex phenotypes, which thus far has remained underanalyzed in genome-wide association studies (GWAS). Here we demonstrate the benefits of including chrX in GWAS by assessing the contribution of 404,862 chrX SNPs to levels of twelve commonly studied cardiometabolic and anthropometric traits in 19,697 Finnish and Swedish individuals with replication data on 5,032 additional Finns. By using a linear mixed model, we estimate that on average 2.6% of the additive genetic variance in these twelve traits is attributable to chrX, this being in proportion to the number of SNPs in the chromosome. In a chrX-wide association analysis, we identify three novel loci: two for height (rs182838724 near FGF16/ATRX/MAGT1, joint P-value = 2.71×10(-9), and rs1751138 near ITM2A, P-value = 3.03×10(-10)) and one for fasting insulin (rs139163435 in Xq23, P-value = 5.18×10(-9)). Further, we find that effect sizes for variants near ITM2A, a gene implicated in cartilage development, show evidence for a lack of dosage compensation. This observation is further supported by a sex-difference in ITM2A expression in whole blood (P-value = 0.00251), and is also in agreement with a previous report showing ITM2A escapes from X chromosome inactivation (XCI) in the majority of women. Hence, our results show one of the first links between phenotypic variation in a population sample and an XCI-escaping locus and pinpoint ITM2A as a potential contributor to the sexual dimorphism in height. In conclusion, our study provides a clear motivation for including chrX in large-scale genetic studies of complex diseases and traits.
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