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- Chin, Kian, et al.
(författare)
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Tumor-infiltrating lymphocytes as a predictor of axillary and primary tumor pathological response after neoadjuvant chemotherapy in patients with breast cancer: a retrospective cohort study
- 2024
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Ingår i: Breast Cancer Research and Treatment. - : SPRINGER. - 0167-6806 .- 1573-7217.
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Tidskriftsartikel (refereegranskat)abstract
- Purpose Tumor-infiltrating lymphocytes (TILs) can predict complete pathological response (pCR) of tumor in the breast but not so well-defined in the axilla after neoadjuvant chemotherapy. Since axillary surgery is being increasingly de-escalated after NACT, we aimed to investigate the relationship between TILs and pCR in the axilla and breast, as well as survival amongst NACT patients.Methods Clinicopathological data on patients who underwent NACT between 2013 and 2020 were retrospectively examined. Specifically, pre-TILs (before NACT), post-TILs (after NACT) and Delta TIL (changes in TILs) were assessed. Primary endpoint was pCR and secondary endpoints were breast cancer-free interval (BCFI) and overall survival (OS).Results Two hundred and twenty patients with nodal metastases were included. Overall axillary and breast pCR rates were 42.7% (94/220) and 39.1% (86/220), respectively, whereas the combined pCR rate was 32.7% (72/220). High pre-TILs (OR 2.03, 95% CI 1.02-4.05; p = 0.04) predicted axillary pCR whereas, high post-TILs (OR 0.33, 95% CI 0.14-0.76; p = 0.009) and increased Delta TILs (OR 0.25, 95% CI 0.08-0.79; p = 0.02) predicted non-axillary pCR. TILs were not a significant predictor for BCFI and OS.Conclusions This study supports the potential use of pre-TILs to select initially node-positive patients for axillary surgical de-escalation after NACT.
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| 3. |
- Haugen, Katarina, 1980-, et al.
(författare)
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The divergent role of spatial access: The changing supply and location of service amenities and service travel distance in Sweden
- 2013
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Ingår i: Transportation Research Part A: Policy and Practice. - : Elsevier. - 0965-8564 .- 1879-2375. ; 49, s. 10-20
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Tidskriftsartikel (refereegranskat)abstract
- This research explores and adds to the literature concerning the relationship between spatial structure and travel behaviour; specifically, the relationship between local and regional accessibility to service amenities and the distance of service-related trips. The analysis is based on a unique combination of national travel survey data for Sweden and official register data with detailed, geo-referenced information about the Swedish population and the location of service amenities in 1995 and 2005/2006. The results show that spatial access to service amenities increased in general over the study period, both locally (i.e., within ranges of 1 km and 5 km, respectively, of residential areas) and regionally (within 50 km). Despite increased spatial accessibility, the observed average travel distance also increased. We find strong and differing associations between spatial access to service amenities and travel distance, depending on level of scale. While the association was negative on the local scale (i.e., a numerically large supply of amenities was related to shorter travel distance), it was the opposite and positive, on the regional scale. In terms of implications for policy, the results imply that land use planning measures to promote local access, and thereby reduce traffic volumes, may per se be insufficient for attaining more sustainable levels of mobility.
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