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Träfflista för sökning "AMNE:(MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area) ;lar1:(hh);pers:(Burkhardt Harald)"

Search: AMNE:(MEDICAL AND HEALTH SCIENCES Basic Medicine Immunology in the medical area) > Halmstad University > Burkhardt Harald

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1.
  • Uysal, Hüseyin, et al. (author)
  • Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis
  • 2009
  • In: Journal of Experimental Medicine. - New York, NY : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 206:2, s. 449-462
  • Journal article (peer-reviewed)abstract
    • Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear. To obtain insight into this question, a panel of mouse monoclonal antibodies was generated against a major triple helical collagen type II (CII) epitope (position 359-369; ARGLTGRPGDA) with or without arginines modified by citrullination. These antibodies bind cartilage and synovial tissue, and mediate arthritis in mice. Detection of citrullinated CII from RA patients' synovial fluid demonstrates that cartilage-derived CII is indeed citrullinated in vivo. The structure determination of a Fab fragment of one of these antibodies in complex with a citrullinated peptide showed a surprising beta-turn conformation of the peptide and provided information on citrulline recognition. Based on these findings, we propose that autoimmunity to CII, leading to the production of antibodies specific for both native and citrullinated CII, is an important pathogenic factor in the development of RA.
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2.
  • Uysal, Hüseyin, et al. (author)
  • The crystal structure of the pathogenic collagen type II-specific mouse monoclonal antibody CIIC1 Fab : Structure to function analysis
  • 2008
  • In: Molecular Immunology. - Oxford : Elsevier. - 0161-5890 .- 1872-9142. ; 45:8, s. 2196-2204
  • Journal article (peer-reviewed)abstract
    • Monoclonal anti-collagen type II antibody CIIC1 is an arthritogenic autoantibody, which induces arthritis in mice. We crystallized and solved the structure of CIIC1 Fab molecule. Analysis of structure revealed an interaction between the CDR regions of one Fab to the CH1 domain of another Fab, which resembles an antibody-antigen interaction. ELISA experiments confirmed the cross-reactivity of both the full CIIC1 antibody and a single chain Fv fragment to other anti-collagen antibodies which are of different isotypes and epitope specificity. The rheumatoid factor like reactivity of CIIC1 antibody together with its collagen type II specificity may explain the pathogenicity of this antibody. © 2007 Elsevier Ltd. All rights reserved.
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