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Investigations on t...
Investigations on the role of ionic liquid on the physicochemical characteristics and toxicological consequences of liposomes
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- Mandal, Manas Kumar (author)
- Department of Chemistry, Vidyasagar University, Midnapore, 721102, West Bengal, India
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- Manna, Emili (author)
- Department of Chemistry, Vidyasagar University, Midnapore, 721102, West Bengal, India
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- Sultana, Habiba (author)
- Department of Chemistry, Vidyasagar University, Midnapore, 721102, West Bengal, India
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- Barai, Manas (author)
- Department of Chemistry, Vidyasagar University, Midnapore, 721102, West Bengal, India
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- Guchhait, Kartik Chandra (author)
- Department of Human Physiology, Vidyasagar University, Midnapore, 721102, West Bengal, India
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- Ghosh, Chandradipa (author)
- Department of Human Physiology, Vidyasagar University, Midnapore, 721102, West Bengal, India
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- Patra, Anuttam (author)
- Luleå tekniska universitet,Kemiteknik
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- Nag, Kaushik (author)
- Department of Biochemistry, Memorial University of Newfoundland, Canada
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- Yusa, Shin-ichi (author)
- Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, Hyogo, 671-2280, Japan
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- Panda, Amiya Kumar (author)
- Department of Chemistry, Vidyasagar University, Midnapore, 721102, West Bengal, India; Sadhu Ram Chand Murmu University of Jhargram, Jhargram, 721507, West Bengal, India
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: JCIS Open. - : Elsevier. - 2666-934X. ; 6
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Effect of 1-butyl-3-methylimidazolium chloride ionic liquid ([bmim]Cl, IL) on the monolayer/bilayer of either soy-phosphatidylcholine (SPC) or hydrogenated soy-phosphatidylcholine (HSPC), in combination with 30 mol% cholesterol (Chol), were investigated. Impact of IL on monolayers were explored by measuring the surface pressure (π)-area (A) isotherm with a Langmuir-surface balance. Lift-off area (A0) of the monomolecular films gradually increased [A0(HSPC+IL) > A0(SPC+IL)], collapse pressures (πc) decreased and passed through minima [πc(HSPC+IL) > πc(SPC+IL)] with increasing IL concentration ([IL]). Minimum molecular area (Amin) increased monotonously and compression moduli (Cs−1) followed the sequence (HSPC+IL) > (SPC+IL) at a particular π with respect to [IL]. Dynamic light scattering studies were carried out to determine the hydrodynamic diameter (dh), zeta potential (Z.P.) and polydispersity index (PDI) values while fluorescence anisotropy studies, using 7-hydroxycoumarin and 1,6-diphenyl-1,3,5-hexatriene, could reveal the micro-viscosity of liposomes. Increased size and rigidity, induced by IL, suggest the formation of leak-proof, condensed liposomes. Disruption of vesicles induced by IL were observed from transmission electron microscopic (TEM) studies. IL induced disintegration of liposome and kinetics of subsequent formation of adsorbed monolayer were accomplished by surface pressure-time isotherms. IL-induced liposomes were substantially less toxic as revealed by MTT assay. These liposomes are considered to be safely used as effective and controlled drug delivery systems.
Subject headings
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Ionic liquid
- Surface pressure
- Monolayers
- Vesicles
- TEM
- Cytotoxicity
- Chemistry of Interfaces
- Gränsytors kemi
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- ref (subject category)
- art (subject category)
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Mandal, Manas Ku ...
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Manna, Emili
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Sultana, Habiba
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Barai, Manas
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Guchhait, Kartik ...
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Ghosh, Chandradi ...
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Patra, Anuttam
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Nag, Kaushik
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Yusa, Shin-ichi
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Panda, Amiya Kum ...
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NATURAL SCIENCES
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MEDICAL AND HEAL ...
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Luleå University of Technology