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| 2. |
- Hope, Michael D., et al.
(author)
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Thoracic Aorta Disease : Flow Evaluation by MR
- 2013. - 3
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In: MRI and CT of the Cardiovascular System. - Philadelphia, PA : Lippincott Williams & Wilkins. - 9781451137316 ; , s. -676
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Book chapter (other academic/artistic)abstract
- Leave no disease undetected with MRI and CT of the Cardiovascular System, your definitive guide to magnetic resonance and computed tomography for cardiovascular health. Authored by a collaboration of international experts, this vivid, four-color third edition imparts the latest technologies in a rapidly advancing field. With topics that range from anatomy, to MR in infants and children, to risk assessment in ischemic heart disease this text includes seven new chapters to reflect the rising tide of technological discovery as it pertains to cardiology. Thanks to its expert analysis, procedural guide to implementation, and profound understanding of the recent advances in cardiovascular imagining, MRI and CT of the Cardiovascular System gives you all the tools necessary for powerful screening, diagnosis, and cardiovascular care. Features:--New chapters reflecting technological discoveries in cardiology --Color illustrations for heightened clarity --Companion website with fully searchable text --Units organized by pathology and disease detection --Fully updated information on application of MR and CT--Up-to-date analysis of emerging multi-detector CT
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| 3. |
- Pigot, Harry, et al.
(author)
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Ex Vivo Working Porcine Heart Model
- 2024. - 2
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In: Experimental Models of Cardiovascular Diseases : Methods and Protocols - Methods and Protocols. - 1940-6029 .- 1064-3745. - 9781071638484 - 9781071638453 - 9781071638460 ; 2803, s. 87-107
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Book chapter (other academic/artistic)abstract
- Ex vivo working porcine heart models allow for the study of a heart’s function and physiology outside the living organism. These models are particularly useful due to the anatomical and physiological similarities between porcine and human hearts, providing an experimental platform to investigate cardiac disease or assess donor heart viability for transplantation. This chapter presents an in-depth discussion of the model’s components, including the perfusate, preload, and afterload. We explore the challenges of emulating cardiac afterload and present a historical perspective on afterload modeling, discussing various methodologies and their respective limitations. An actively controlled afterload device is introduced to enhance the model’s ability to rapidly adjust pressure in the large arteries, thereby providing a more accurate and dynamic experimental model. Finally, we provide a comprehensive experimental protocol for the ex vivo working porcine heart model.
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| 4. |
- Rönmark, Eva, et al.
(author)
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Day-care and schools
- 2010
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In: Occupational and environmental lung diseases. - Chichester, UK : John Wiley & Sons. - 9780470515945 - 9780470710425 ; , s. 107-120
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Book chapter (peer-reviewed)
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| 5. |
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| 6. |
- Johnsson, Åse (Allansdotter), 1966, et al.
(author)
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Incidental findings and their handling in the Swedish CArdioPulmonary bioimage study (SCAPIS)
- 2017
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In: Incidental Radiological Findings. - Cham : Springer International Publishing. - 0942-5373 .- 2197-4187. - 9783319425818 - 9783319425795 - 9783319826127 ; , s. 91-101
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Book chapter (peer-reviewed)abstract
- The Swedish CArdioPulmonary bioImage Study (SCAPIS) combines the use of new imaging technologies, large-scale proteomics/metabolomics/genomics, and epidemiological analyses to extensively characterize a Swedish cohort of 30,000 men and women aged between 50 and 64 years. Its main aims are to improve risk prediction and to optimize our ability to study mechanisms of cardiopulmonary diseases. SCAPIS is currently recruiting at six sites in Sweden, and a pilot study was conducted in 2012 to test the feasibility of the comprehensive study protocol. In the planning phase, it was recognized that the detailed phenotyping used in SCAPIS would identify a large number of clinical findings in need of medical attention. This was confirmed by evaluation of results from the pilot study. Here we focus on pulmonary nodules and asymptomatic coronary artery stenosis. These clinical features were observed in a large number of participants, and the clinical handing and prognosis related to these observations are unclear. They thus posed great challenges for the study in their practical and ethical handling. This chapter describes how we developed procedures to handle these findings based on existing evidence and expert consensus as well as deliberations on ethical issues.
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| 8. |
- Sager, Morten, 1972
(author)
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Evidens i administrativt limbo : Den implanterbara defibrillatorn mellan forskning och klinik
- 2011
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In: Evidensens många ansikten. - Lund : Arkiv Förlag. - 9789179242282 ; , s. 97-129
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Book chapter (other academic/artistic)abstract
- Den grundläggande målsättningen inom evidensbaserad medicin (EBM) är att den kliniska praktiken skall bygga på forskning av tillräckligt hög kvalitet. Praktiserande vårdpersonal skall alltså inte bara fatta beslut utifrån individuella erfarenheter och existerande rutiner utan också och kanske främst ta hänsyn till nya forskningsrön, det vill säga ”evidens”. Det innebär att det finns två centrala komponenter i evidensbaserad medicin som de flesta aktörer – åtminstone på ett grundläggande plan – är eniga om: bästa möjliga kunskap (evidens) skall användas i beslut om åtgärder i sjukvården (medicinen). Medan EBM står för denna allmänt omfattade ambition har konceptet också definierats mer specifikt av myndigheter och organisationer i termer av vissa metoder och kunskapstyper. Det har etablerats graderingar av evidensstyrka där välgjorda randomiserade kliniska studier (RCT:er) och systematiska översikter getts störst vikt. Evidensbaserad medicin antas uppnå sitt mål när en kunskapsmässig kedja etableras från kliniska studier, vidare till systematiska sammanställningar och sist till införandet av rekommenderade behandlingar i klinisk praktik. Mot bakgrund av den enighet som råder om EBM:s allmänna mål och de detaljerade definitioner som görs av myndigheter är det intressant att granska hur olika aktörer inom vården längre ned i den tänkta evidenskedjan faktiskt beter sig och tänker. Är EBM viktig för dessa aktörer och vad menar man med det i så fall? Hur tänker sig olika aktörer att vår- den skall utformas med EBM i åtanke? Ännu mer förenklat: vad innebär evidensbaserad medicin ute i den kliniska verkligheten? Detta är huvudfrågan i kapitlet. Frågan ställs i förhållande till implementeringen av en implanterbar defibrillator i ett svenskt landsting.
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| 9. |
- Henein, Michael Y., et al.
(author)
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Diabetes and coronary circulation : from pathology to imaging
- 2021
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In: Diabetes and cardiovascular disease. - Amsterdam : Elsevier. - 9780128174289 ; , s. 227-267
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Book chapter (peer-reviewed)abstract
- Coronary artery disease (CAD) is the leading cause of mortality and morbidity among patients with diabetes mellitus. Despite the large fall in CAD mortality in the general population over the last four decades, the overall risk of CAD in people with diabetes did not change significantly. Compared to the general population, diabetics have a higher prevalence, extent, and severity of CAD and a higher risk of mortality due to myocardial infarction and to a lesser extent to stroke. Also, cardiovascular disease has been shown to develop earlier in individuals with diabetes and is followed by worse event-related survival than in nondiabetics. Although most data on the relationship between diabetes and CAD refer to type 2 diabetes, cardiovascular disease remains the leading cause of mortality even in patients with type 1 diabetes. Chronic hyperglycemia and insulin resistance have a key role in inducing coronary atherosclerosis by promoting inflammation and endothelial dysfunction. In diabetic patients, once the coronary atherogenesis has started, the progression from early lesions to plaque rupture or erosion follows the same pathological pathway as in the general population. Although the risk of CAD has been traditionally associated with coronary stenosis severity, more recent research has led to a paradigm shift, with more emphasis on total coronary plaque burden. Both clinical and postmortem studies have shown that diabetics have significantly greater total plaque burden compared to nondiabetics. Direct, invasive, and noninvasive visualization of atherosclerotic lesions allows accurate evaluation of the extent of disease and degree of plaque calcification. However, imaging of the presence and extent of plaque inflammatory activity, using positron emission tomography or cardiac magnetic resonance, may serve in identifying individuals with a more severe atherosclerotic disease who may benefit from intensive treatment.
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| 10. |
- Erfurth, Eva Marie
(author)
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Obesity and metabolic disturbances in adamantinomatous craniopharyngioma patients
- 2017
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In: Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma. - Cham : Springer International Publishing. - 9783319518909 - 9783319518886 ; , s. 85-99
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Book chapter (peer-reviewed)abstract
- An adamantinous craniopharyngioma (CP) is rare benign pituitary tumour often growing invasively and thereby affecting the hypothalamus. The recurrence rate in CP is high and therapy of choice is surgery, followed by cranial radiotherapy (CRT) in about half of the patients. Patients with CP have a 3-19 fold higher cardiovascular mortality in comparison to the general population. The majority of patients have an extended hypopituitarism that needs balanced hormone supplementation. About half of the patient population suffer from hypothalamic damage due to the tumour or operation. These patients suffer from hypothalamic obesity together with increased vascular morbidity and compromised bone health, thirst disorders as well as somnolence and sleep apnea. Cardiovascular risk factors need up front therapy. There is a need for centralising this rare aggressive and difficult tumour to only a few centres and that it will be managed by a multidisciplinary team with experienced neurosurgeons, endocrinologists, neurooncologists, neuroradiologists, and neuroopthamologists for a better prognosis.
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