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1.	Orlova, Anna, et al. (author) Cellular processing of 125I- and 111in-labeled epidermal growth factor (EGF) bound to cultured A431 tumor cells 2000 In: Nuclear Medicine and Biology. - 0969-8051 .- 1872-9614. ; 27:8, s. 827-835 Review (other academic/artistic)abstract Low molecular weight of epidermal growth factor (EGF) enables better intratumoral penetration in comparison with larger targeting proteins, but the cellular retention of EGF-associated radioactivity is poor for directly iodinated EGF. An attempt was made to improve intracellular retention by the use of metal-diethylenetriaminepentaacetic acid or nonphenolic linker (N-succinimidyl-para-iodobenzoate) as labeling agents. The use of nonphenolic linker did not improve retention of the radioactivity in A431 carcinoma cell line. The use of the radiometal label provided an appreciable prolongation of radioactivity residence inside the cell.
2.	Orlova, Anna, et al. (author) Cellular processing of indirectly astatinated and iodinated mAb A33 in SW1222 cultured cells 2001 In: Journal of labelled compounds & radiopharmaceuticals. - : Wiley. - 0362-4803 .- 1099-1344. ; 44:suppl 1, s. S715-S717 Review (other academic/artistic)abstract In principle, alpha-emitting radionuclides, such as 211At, are more efficient than beta-emitters to inactive single disseminated cancer cells. However, cellular processing of astatinated proteins has not yet been studied in detail. In this study an anti-colorectal cancer monoclonal antibody (mAb) A33 was indirectly labeled with 211At and for comparison with 125I. Binding and retention of radioactivity was studied in the colorectal cancer cell-line SW1222. A similar pattern of binding and retention of the two radiohalogens was seen. The main difference found, that the retention time of astatinated mAb in SW1222 was almost two times longer, might be of advantage in radionuclide therapy.

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Type of publication: review (2)Undo refine

Type of content: other academic/artistic (2)

Author/Editor: Lundqvist, Hans (2); Orlova, Anna (2); Sjöström, Anna (2)Undo refine; Tolmachev, Vladimir (1); Ericson, A (1); Gedda, Lars (1); show more...; Carlsson, Jörgen (1); Bruskin, Alexander (1); Lebeda, Ondrej (1); Tolmavhev, Vladimir (1); show less...

University: Uppsala University (2)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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