1. |
|
|
2. |
- Eklund, Johan
(författare)
-
Searching for genetical cancer risks using a database of familial cancer : part I
- 1999
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A method to estimate cancer risks, when a recessive genetic defect is assumed to influence the risk to develop cancer, is presented. The proportion of the recessive defect is also estimated. The method uses cancer diagnosis data from a large sample of biological families. A family is here parents and two children. The information used is the frequencies of cancer diagnoses among siblings. Estimations are performed with the method of moments. The work is methodological, meaning that no specific type of cancer is considered.
|
|
3. |
|
|
4. |
- Wiklund, Fredrik, et al.
(författare)
-
Prediction of cancer incidence
- 1998
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In this paper a method for predicting future number of cancer diagnoses is derived. The method is based on estimation of the cumulative hazard of cancer diagnosis and cumulative hazard of population mortality. The estimation of cancer hazard is done non-parametrically, while the population death hazard is assumed to follow the Gompertz-Makeham distribution. The prediction is based on the assumption that cancer incidence and population mortality in the prediction intervals are derived. Also, prediction intervals, based on non-parametric bootstrap, are presented. The method is applied to predict number of colon cancer diagnoses among females in the northern part of Sweden. It has shown to detect and adjust for changes in population age structure, and to provide good predictions in situation where the cancer incidence and population mortality are stable during the prediction period.
|
|
5. |
|
|
6. |
|
|
7. |
|
|
8. |
|
|
9. |
|
|
10. |
|
|