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- Aitken, Candice L., et al.
(author)
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Comparison of three methods used for fusion of SPECT-CT images of liver matastases
- 1998
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In: Fusion98, International Conference on Multisource-Mulltisensor Information Fusion. - : CSREA Press. - 1892512009 ; , s. 435-442
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Conference paper (peer-reviewed)abstract
- We compare three methods for fusing SPECT-CT images: ImageMatch - an automatic three-dimensional/two-dimensional method developed by Focus Imaging; IBM Visualization Data Explorer - a three-diemensional interactive method developed by Internation Business Machines, Inc.; and qsh - an interactive three-dimensional/two-dimensional method developed at New York University. While many fusion methods have proved successful for registering brain images, most methods have been less successful for thoracic and abdominal images. We use images of liver metastases obtained with a radiolabeled breast tumor-directed antibody to illustrate the strengths and weakness of the methods reviewed. The images used are typical clinical images from eigth patients. We conclude that an optimal image fusion program should combine the strengths of each of the methods reviewed.
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- Aitken, Candice L., et al.
(author)
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Tumor localization and image registration of 18-FDG SPECT scans with CT scans
- 1999
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In: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667. ; 40:5, s. 290P-291P
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Journal article (peer-reviewed)abstract
- PURPOSE: The aim of this study was to determine the feasibility of registering routine clinical F-18 fluorodeoxyglucose (FDG) coincidence detection (CD) scans with computed tomographic (CT) scans for radiation treatment planning and case management. METHODS: F-18 FDG CD and chest CT scans, performed in 10 randomly selected patients with confirmed or possible adenocarcinoma of the lung, were evaluated. The quality of the matches was verified by comparisons of the center-to-center distance between a region of interest (ROI) manually drawn on the CT slice and warped onto the CD slice with an ROI drawn manually directly on the CD slice. In addition, the overlap between the two ROIs was calculated. RESULTS: All 10 F-18 FDG CD and CT scans were registered with good superimposition of soft tissue density on increased radionuclide activity. The center-to-center distance between the ROIs ranged from 0.29 mm to 8.08 mm, with an average center-to-center distance of 3.89 mm +/- 2.42 mm (0.69 pixels +/- 0.34 pixels). The ROI overlap ranged from 77% to 99%, with an average of 90% +/- 5.6%. CONCLUSIONS: Although the use of F-18 FDG CD shows great promise for the identification of tumors, it shares the same drawbacks as those associated with radiolabeled monoclonal antibody SPECT and ligand-based positron emission tomographic scans in that anatomic markers are limited. This study shows that image registration is feasible and may improve the clinical relevance of CD images.
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| 3. |
- Farrell, Edward J., et al.
(author)
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Graphical 3D medical image registration and quantification
- 1997
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In: Journal of medical systems. - 0148-5598 .- 1573-689X. ; 21:3, s. 155-172
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Journal article (peer-reviewed)abstract
- We present a graphical three-dimensional method that facilitates image registration and fusion, and provides quantitative geometric and volume information. In particular it enhances the use of functional (radiopharmaceutical) imaging {(SPECT}, {PET)} which, though a powerful clinical tool, has the disadvantage of low spatial resolution and ill-defined boundaries. Registration between functional images and structural images {(MRI}, {CT)} can augment the anatomical context of these functional images.
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| 4. |
- Farrell, Edward J., et al.
(author)
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Quantitative 3D visualization in nuclear medicine
- 1995
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In: Proceedings of the SPIE Medical Imaging 1995. - : SPIE - International Society for Optical Engineering. - 0819417793 ; , s. 54-64
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Conference paper (peer-reviewed)abstract
- SPECT is a powerful clinical tool. However, the low spatial resolution and ill-defined boundaries associated with SPECT require special consideration in visualization. Quantitative geometric and magnitude information are areas of particular usefulness in evaluating disease states. In this paper, we describe a set of practical 3D visualization tools to display and analyze SPECT data, and present interactive methods to measure (1) the relative position, size and shape of regions of interest and (2) the magnitude and distribution of radioactive count information. Interactive pick tools allow users to extract values at selected points, distance between points, or value profiles along selected line segments. In the three-dimensional reconstruction, transparent and opaque isosurfaces are formed simultaneously at specified activity levels, and the volume enclosed by the opaque surface is displayed. The utility of these tools is demonstrated with two types of patient studies: those using tumor-avid agents to identify active tumor in the chest and abdomen, and those used for evaluating the volume of perfused myocardium.
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| 10. |
- Spevack, Daniel M., et al.
(author)
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Feasibility of quantification of unreconstructed SPECT projection views using the opposing view method
- 1996
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In: SPIE - The International Society for Optical Engineering. - : SPIE - International Society for Optical Engineering. ; , s. 734-741
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Conference paper (peer-reviewed)abstract
- When single photon emission computer aided tomography (SPECT) is performed, planar projection views are taken at a series of stepping angles covering the entire arc around the patient. These projection views are identical to planar gamma camera images, except that they are generally taken with a shorter acquisition time. The projection views are reconstructed to create transaxial SPECT images via backprojection techniques. We attempted the following studies to show that opposing SPECT projection views could yield the same correct quantitative information as the planar gamma camera images. Planar and SPECT images were used from patients who had received 0.135 MBq (5 mCi) of In-111-methyl benzyl DTPA BrE- 3 monoclonal antibodies. An In-111 filled flat flood source was utilized to acquire transmission images on the planar gamma camera in order to generate an attenuation map of the patient in the anterior/posterior plane. A camera calibration factor was obtained using a source of known activity. The activity of the liver was determined from abdominal planar images using regions of interest (ROIs) drawn around the liver on opposing anterior and posterior views. Similarly, the activity of the liver was determined from the opposing SPECT projection images which showed the anterior and posterior views. The same attenuation map was used for the correction of both the planar images and SPECT projection views. A cylindrical plastic phantom containing spherical plastic balls was used to validate that this technique accurately measured the activity contained in selected ROIs. Planar and SPECT images were taken of the phantom with each ball containing 6.8 kBq (250 (mu) Ci) of Tc- 99m. A Tc-99m filled flat flood source was utilized to acquire transmission images on the planar gamma camera, and a source of known activity was used to obtain a camera calibration. Using a similar method to that used on the liver images, the activity of the balls was determined from the planar images and the SPECT projection views. Liver activities calculated from SPECT projection views matched the activities calculated from the planar images within 20% error. The activities for each ball in the phantom, calculated from SPECT projection views, matched the activity calculated from the planar images within 5% error, and matched the known activity in each ball within 10% error. The data indicates that despite their short acquisition times, the SPECT projection views may be used to quantify the activity from ROIs, without a significant increase in error associated with activity measurement.
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