| 1. |
- Robinson, Yohan, 1977-, et al.
(författare)
-
Do biological disease-modifying antirheumatic drugs reduce the spinal fracture risk related to ankylosing spondylitis? : A longitudinal multiregistry matched cohort study
- 2017
-
Ingår i: BMJ Open. - London, UK : BMJ Publishing Group Ltd. - 2044-6055. ; 7:12
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: Ankylosing spondylitis (AS) is associated with an increased spinal fracture risk due to the loss of elasticity in spinal motion segments. With the introduction of biological disease-modifying antirheumatic drug (bDMARD) treatment for AS, the individual course of the disease has been ameliorated. This study aims to examine the association of bDMARD treatment and risk of spinal fracture.Design: Longitudinal population-based multiregistry observational matched cohort study.Setting: Swedish Patient Registry 1987-2014 and Swedish Prescribed Drugs Registry 2005-2014.Participants: Included were patients ≥18 years of age receiving treatment at a healthcare facility for the primary diagnosis of AS. About 1352 patients received more than one prescription of bDMARD from 2005 to 2014. An untreated control group was created by propensity score matching for age, sex, comorbidity, antirheumatic prescriptions and years with AS (n=1352).Main Outcome Measures: Spinal fracture-free survival.Results: No bDMARD treatment-related effect on spinal fracture-free survival was observed in the matched cohorts. Male gender (HR=2.54, 95% CI 1.48 to 4.36) and Charlson Comorbidity Index score (HR=3.02, 95% CI 1.59 to 5.75) contributed significantly to spinal fracture risk.Conclusion: bDMARD had no medium-term effect on the spinal fracture-free survival in patients with AS.Trial Registration Number: NCT02840695
|
|
| 2. |
- Kalezic, Nebojsa, et al.
(författare)
-
Physiological reactivity to functional tests in patients with chronic low back pain
- 2007
-
Ingår i: Journal of Musculoskeletal Pain. - Binghamton : Haworth Press. - 1058-2452 .- 1540-7012. ; 15:1, s. 29-40
-
Tidskriftsartikel (refereegranskat)abstract
- Objectives: The aim of the present study was to investigate autonomic regulation at rest and in response to functional laboratory tests in patients with chronic low back pain [CLBP], as well as its possible relations to different characteristics of the clinical picture.Methods: Ninety-three CLBP patients [47 females, 45 males; age 38 +/- 7 years] and 32 healthy normal control subjects [15 females, 16 males: 36 +/- 9 years] participated. Subjects were examined according to the McKenzie procedure, and filled in Short Form 36 and Oswestry Disability Questionnaires in addition to self-reports of pain. An electrocardiogram, finger plethysmogram, respiration, and skin conductance were recorded. Functional tests included the Stroop Color-Word test, orthostatic test, paced breathing, and handgrip. A five-minute baseline recording was followed by four counterbalanced functional tests, separated by two- to three-minute long pauses.Results: An analysis of variance revealed higher baseline heart rate [P=0.011 in females only], low frequency spectral power [P=0.001] and electrodermal activity [P=0.048], and lower high frequency spectral power [P=0.001]. Each functional test evoked a response, without any group differences in physiological reactivity. There were no significant differences with respect to physiological reactivity between subgroups formed on the basis of prior diagnoses, McKenzie evaluation, VAS pain estimates, Short Form 36, and Oswestry Disability Questionnaire data. The patients did not show high levels of individual response specificity.Conclusions: Presented data show that patients with CLBP exhibit increased sympathetic tonus in comparison with the control group, regardless of CLBP patients' level of pain, functional disability, or clinical status indices.
|
|
| 3. |
- Svendsen, Susanne Wulff, et al.
(författare)
-
Work above shoulder level and degenerative alterations of the rotator cuff tendons : a magnetic resonance imaging study.
- 2004
-
Ingår i: Arthritis and rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 50:10, s. 3314-22
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To determine whether work performed with the arms in a highly elevated position is associated with alterations in the rotator cuff tendons as assessed by magnetic resonance imaging (MRI). METHODS: A cross-sectional study was performed in a historical cohort of male machinists, car mechanics, and house painters. The participants were right-handed, ages 40-50 years, and had been employed in their trades for not less than 10 years. Seventy-one percent of invited subjects participated (136 of 192). Lifetime upper arm elevation was assessed by direct measurements combined with individual work histories obtained by questionnaire and from registry data. Supraspinatus tendinopathy was evidenced by MRI signal intensity changes and morphologic alterations. Infraspinatus and subscapularis tendinopathy were also assessed. Additional outcomes were acromioclavicular joint degeneration and humeral head cysts. The MRI findings were evaluated by radiologists who were blinded to exposure status and symptoms. RESULTS: An exposure-response relationship was found between lifetime upper arm elevation and supraspinatus tendinopathy, with an age-adjusted odds ratio of 1.27 (95% confidence interval 1.02-1.60) for a 5-month increase in the total number of full-time working months spent with the arm elevated >90 degrees . CONCLUSION: Work with the arms in a highly elevated position is associated with MRI-diagnosed alterations in the supraspinatus tendon. By demonstrating the first part of a possible biologic pathway, the study corroborates the work-relatedness of rotator cuff disorders.
|
|
