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Sökning: AMNE:(MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation) > Jönköping University > (2010-2014) > Theorell Tores > Job strain and the ...

Job strain and the risk of inflammatory bowel diseases : individual-participant meta-analysis of 95 000 men and women

Heikkila, Katriina (författare)
Finnish Institute of Occupational Health, Helsinki, Finland
Madsen, Ida E. H. (författare)
National Research Centre for the Working Environment, Copenhagen, Denmark
Theorell, Töres (författare)
Stockholms universitet,Karolinska Institutet,Stressforskningsinstitutet
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Fransson, Eleonor (författare)
Stockholms universitet,Karolinska Institutet,Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. ADULT,Stressforskningsinstitutet,Karolinska Institutet, Sweden; Jönköping University, Sweden
Ahola, Kirsi (författare)
Finnish Institute of Occupational Health, Helsinki, Finland
Alfredsson, Lars (författare)
Karolinska Institutet
Bjorner, Jakob B. (författare)
National Research Centre for the Working Environment, Copenhagen, Denmark
Borritz, Marianne (författare)
Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark
Burr, Hermann (författare)
Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany
Dragano, Nico (författare)
Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany
Ferrie, Jane E. (författare)
Department of Epidemiology and Public Health, University College London, London, United Kingdom,School of Community and Social Medicine, University of Bristol, Bristol, United Kingdom
Knutsson, Anders (författare)
Mittuniversitetet,Avdelningen för hälsovetenskap,Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden
Koskenvuo, Markku (författare)
Department of Public Health, University of Helsinki, Helsinki, Finland
Koskinen, Aki (författare)
Finnish Institute of Occupational Health, Helsinki, Finland
Nielsen, Martin L. (författare)
Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark
Nordin, Maria (författare)
Umeå universitet,Institutionen för psykologi,Department of Psychology, Umeå University, Umeå, Sweden
Pejtersen, Jan H. (författare)
The Danish National Centre for Social Research, Copenhagen, Denmark
Pentti, Jaana (författare)
Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland
Rugulies, Reiner (författare)
National Research Centre for the Working Environment, Copenhagen, Denmark
Oksanen, Tuula (författare)
Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland
Shipley, Martin J. (författare)
Department of Epidemiology and Public Health, University College London, London, United Kingdom
Suominen, Sakari B. (författare)
Folkhälsan Research Center, Helsinki, Finland
Theorell, Tores (författare)
Vaananen, Ari (författare)
Finnish Institute of Occupational Health, Helsinki, Finland
Vahtera, Jussi (författare)
Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland
Virtanen, Marianna (författare)
Finnish Institute of Occupational Health, Helsinki, Finland
Westerlund, Hugo (författare)
Stockholms universitet,Stressforskningsinstitutet
Westerholm, Peter J. M. (författare)
Uppsala universitet,Arbets- och miljömedicin
Batty, G. David (författare)
Department of Epidemiology and Public Health, University College London, London, United Kingdom
Singh-Manoux, Archana (författare)
Department of Epidemiology and Public Health, University College London, London, United Kingdom
Kivimaki, Mika (författare)
Department of Epidemiology and Public Health, University College London, London, United Kingdom,Finnish Institute of Occupational Health, Helsinki, Finland
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 (creator_code:org_t)
2014-02-18
2014
Engelska.
Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 9:2, s. e88711-
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background and Aims: Many clinicians, patients and patient advocacy groups believe stress to have a causal role in inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. However, this is not corroborated by clear epidemiological research evidence. We investigated the association between work-related stress and incident Crohn's disease and ulcerative colitis using individual-level data from 95 000 European adults. Methods: We conducted individual-participant data meta-analyses in a set of pooled data from 11 prospective European studies. All studies are a part of the IPD-Work Consortium. Work-related psychosocial stress was operationalised as job strain (a combination of high demands and low control at work) and was self-reported at baseline. Crohn's disease and ulcerative colitis were ascertained from national hospitalisation and drug reimbursement registers. The associations between job strain and inflammatory bowel disease outcomes were modelled using Cox proportional hazards regression. The study-specific results were combined in random effects meta-analyses. Results: Of the 95 379 participants who were free of inflammatory bowel disease at baseline, 111 men and women developed Crohn's disease and 414 developed ulcerative colitis during follow-up. Job strain at baseline was not associated with incident Crohn's disease (multivariable-adjusted random effects hazard ratio: 0.83, 95% confidence interval: 0.48, 1.43) or ulcerative colitis (hazard ratio: 1.06, 95% CI: 0.76, 1.48). There was negligible heterogeneity among the study-specific associations. Conclusions: Our findings suggest that job strain, an indicator of work-related stress, is not a major risk factor for Crohn's disease or ulcerative colitis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
SAMHÄLLSVETENSKAP  -- Psykologi (hsv//swe)
SOCIAL SCIENCES  -- Psychology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)

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