| 1. |
- Lundgren, Stina, 1952-, et al.
(författare)
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Smärta vid artrit
- 2007
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Ingår i: Långvarig smärta. - Lund : Studenlitteratur. - 9789144019741 ; , s. 119-143
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Kylén, Erik, et al.
(författare)
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Development of an Animated Video for Pre- and Postoperative Learning for Osteoarthritis Patients
- 2020
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Ingår i: Education and New Developments 2020. - Lisboa, Portugal. - 9789895481521 ; , s. 428-432
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Osteoarthritis (OA) is a condition in the joint that is developing for a long time and hit first and mainlyarticular cartilage, and it is a long-term chronic disease characterized by deterioration. In the final stage itis affected all the tissues of the joints such as bones, ligaments, arthritis, joint fluid and muscles, whichresults in bones rubbing together and creating stiffness, pain, and impaired movement. This disease canaffect the joints in the knees, hands, feet, spine and shoulder. OA is the single most common cause ofdisability in older adults worldwide. Patients need to receive detailed information about the disability,learn about their disease, its treatment and how to follow recommendations both before and after thesurgery. As hospital stays are shortening the need of information is increasing, as the patients need toprepare themselves at home before the operation, as well as take care of their rehabilitation when they arecoming home, discharged from hospital. In this paper we present a case study about the development of aweb-based animated video that was developed to support the learning for patients with OA, using adesign science research approach. DSR is an iterative process that include three iterative research cycles.The relevance cycle provided the requirements for the application from the very beginning. The relevancecycle, the rigor cycle and the design cycle were conducted iteratively, and have generated designalternatives that have been evaluated in discussions with OA surgery physicians, as representatives fromthe application domain.
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| 3. |
- Aggestam, Lena, et al.
(författare)
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The Development and Evaluation of an Animated Video for Pre- and Postoperative Instructions for Patients with Osteoarthritis : A Design Science Research Approach
- 2024
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Ingår i: Geriatrics. - 2308-3417. ; 9:19, s. 1-11
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Tidskriftsartikel (refereegranskat)abstract
- Osteoarthritis (OA) is a condition in the hip or knee joints that develops during a long period of time and sometimes needs hip or knee joint replacement surgery when pain gets too intense for the patient. This paper describes how an animated video for pre- and postoperative instructions for patients with osteoarthritis was designed. The design science research (DSR) approach was followed by creating a web-based animated video. The web-based animated video is used to support surgical departments with education for patients suffering from OA. In the web-based animated video, information about OA surgical treatment and its pre- and post-arrangements was included. The relevance, the rigor, and the design cycles were focused on, with some iterations of and improvements in the animations. Even after implementation, there was a feedback-loop with comments from the surgeons and their patients. Moreover, as more departments will use the web-based animated video, they want to make their special mark on it, so that further changes will be made. This paper presents the design and successful implementation of an animated video for pre- and postoperative instructions for patients with osteoarthritis, tightly linked to the patient journey and the workflow of healthcare professionals. The animated video serves not only as a tool to improve care but also as a basis for further scientific research studies.
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| 4. |
- Lind, Simon, 1993, et al.
(författare)
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Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949
- 2019
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Ingår i: Biochemical Pharmacology. - : Elsevier BV. - 0006-2952 .- 1356-1839 .- 1873-2968. ; 166, s. 163-173
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Tidskriftsartikel (refereegranskat)abstract
- Despite the steadily increased numbers of formyl peptide receptor (FPR) ligands identified over the years, few have been characterized in studies using animal disease models and even less have entered clinical trials in human subjects. A small-molecule compound, Act-389949, was however recently tested in a phase I clinical trial and found to be safe and well tolerated in healthy human subjects. The desired anti-inflammatory property of Act-389949 was proposed to be mediated through FPR2, one of the FPRs expressed in neutrophils, but no basic characterization was included in the study. To gain more insights into FPR2 recognition of this first-in-class compound for future utility of the agonist, we have in this study determined the receptor preference and downstream signaling characteristics induced by Act-389949 in human blood neutrophils isolated from healthy donors. Our data demonstrate that Act-389949 is an agonist for FPR2 that triggers functional/signaling repertoires comparable to what has been earlier described for other FPR2 agonists, including neutrophil chemotaxis, granule mobilization and activation of the NADPH-oxidase. In fact, Act-389949 was found to be as potent as the prototype FPR2 peptide agonist WKYMVM and had the advantage of being resistant to oxidation by MPO-H2O2 halide derived oxidants, as compared to the sensitive WKYMVM. The down-stream signals generated by Act-389949 include an FPR2-dependent and Gaq-independent transient rise in intracellular Ca2+ and recruitment of beta-arrestin. In summary, our data show that Act-389949 serves as an excellent tool-compound for further dissection of FPR2-regulated activities in vitro and in vivo. Potent and stable FPR ligands such as Act-389949 may therefore be used to develop the next generation of FPR signaling regulating anti-inflammatory therapeutics.
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