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Träfflista för sökning "AMNE:(MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper) ;mspu:(conferencepaper)"

Sökning: AMNE:(MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper) > Konferensbidrag

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1.	Abbas, Abdul-Karim, 1959, et al. (författare) Long-term potentiation and insult conditioning in hippocampal slices from young rats: a role for protein synthesis under chemical stress? 2010 Ingår i: The 10th Biennial Meeting of the Asia-Pacific Society for Neurochemistry (APSN), October 17-20, 2010, Phuket, Thailand. Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract We have previously demonstrated that in young rats (12-20-day-old) a sustained long-term potentiation (LTP) can still be induced under conditions of protein synthesis inhibition. It was therefore suggested that sufficient and necessary proteins were already available at the induction time to accomplish LTP maintenance for several hours. Against this background, we have questioned whether hippocampal slices subjected to certain insult conditions might be more sensitive to protein synthesis inhibitors. High K+ concentration has previously been reported to cause an amnesic effect in vivo as well as increasing protein turnover in vitro. We have here employed a K+ insult model under conditions when protein synthesis was inhibited. Recordings were obtained from hippocampal slices for up to 9 h, with or without a cocktail of protein synthesis inhibitors, containing cycloheximide (60 µM) and anisomycin (25 µM). High potassium (50 mM) was transiently applied (5-15 min) shortly after inducing LTP in one of two separate pathways stimulated alternatively. Additionally, an NMDA-receptor antagonist AP5 was supplied after LTP induction to minimize effects related to depolarization-induced glutamate release. Following elimination of all responses for about 30 min, both test and control responses partly recovered. The degree of remaining LTP, defined as test/control ratio, was reduced in both groups of slices (NMDA-independent depotentiation) but was significantly smaller in the drug-treated ones. We are also running an insult model based on oxidative stress, applying hydrogen peroxide (4-5 mM) before or after LTP induction; however, the results are still insufficient for a final conclusion. The potency of cycloheximide, anisomycin or cocktail of the drugs was verified by measurement of incorporation of [3H]-leucine into trichloracetic acid (TCA) precipitable macromolecules. Cycloheximide, anisomycin or cocktail, at concentrations used here caused 95%, 97% and 95% blocking effect, respectively. Our data confirm the idea that sufficient and necessary constitutive proteins are available in the young hippocampus to maintain LTP under conditions of protein synthesis inhibition. They also reveal that LTP in slices subjected to certain insult conditions early after the induction is sensitive to protein synthesis inhibition, probably due to increase in constitutive proteins turnover.
2.	Munthe, Christian, 1962 (författare) Ethical aspects on prioritisation of new cancer drugs 2015 Ingår i: 11th Nordic Melanoma Meeting, Gothenburg, 3 September, 2015. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
3.	Helldén, Anders, et al. (författare) Aciclovir- a nearly atoxic antiviral drug with severe neurotoxic side effects. A retrospective review of 280 cases and the importance of analysing the aciclovir metabolite CMMG. 2008 Ingår i: 2nd World Conference on Magic Bullets (Ehrlich II) Nürnberg, Germany 2008. Konferensbidrag (refereegranskat)abstract Aciclovir- a nearly atoxic antiviral drug with severe neurotoxic side effects. A retrospective review of 280 cases and the importance of analysing the aciclovir metabolite CMMG.
4.	Rolfö, Linda, et al. (författare) Predictors of Preference for the Activity-based Flexible Office 2019 Ingår i: Human Systems Engineering and Design. - Cham : Springer. - 9783030020521 - 9783030020538 ; 876, s. 547-553 Konferensbidrag (refereegranskat)abstract Activity-based Flexible Offices (A-FOs) are implemented with varying degree of success. Employees relocate from cell or open-plan offices, from different organizational backgrounds, varying design and implementation processes, and have different types of work tasks. This study aims at investigating whether preference for the A-FO correlate with these preconditions. The results from Chi-square tests and Spearman’s non-parametric correlation of post-relocation questionnaires distributed to 11 A-FO sites, showed that a high preference for the A-FO correlated strongest with an A-FO preference prior to relocation, being a former open-plan office occupier and with frequent performance of innovation. Low preference for the A-FO correlated with frequent performance of concentration demanding tasks. Working with tasks with high confidentiality did not predict the preference ratings.
5.	Backhaus, Thomas, 1967, et al. (författare) Observed and predicted mixture toxicities of quinolone and fluoroquinolone antibiotics 2005 Ingår i: 15th annual meeting SETAC - Europe (Society for Environmental Toxicology and Chemistry) 22 - 26 May 2005, Lille, France (oral presentation). Konferensbidrag (refereegranskat)
6.	Meyer, W, et al. (författare) Predictability of combination effects of mixtures of estrogenic substances: Comparison of different classes of chemicals 2004 Ingår i: 14th annual meeting SETAC - Europe (Society for Environmental Toxicology and Chemistry), 18 - 22 April 2004, Prague, Czech Republic (oral presentation). Konferensbidrag (refereegranskat)
7.	Borrelli, Pablo, et al. (författare) Artificial Intelligence Based Method for Automated PET/CT Measurements of Prostate Gland Volume and Choline Uptake 2018 Ingår i: European Journal of Nuclear Medicine and Molecular Imaging. - 1619-7070 .- 1619-7089. ; 45:Supplement: 1, s. S531-S532 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
8.	Stryamets, Natalya, et al. (författare) Non-wood forest products for local rural livelihoods in Europe’s East and West 2015 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
9.	Junghans, Marion, et al. (författare) A mathematical framework defining the relation between CA and IA – an application to realistic agricultural exposure scenarios 2007 Ingår i: SETAC - Europe (Society for Environmental Toxicology and Chemistry), Annual Conference, 2007, Porto, Portugal. Konferensbidrag (övrigt vetenskapligt/konstnärligt)
10.	Mardinoglu, Adil, 1982, et al. (författare) Integrated Network Modeling for Novel Target Searches and Better Predictive Models 2016 Ingår i: Journal of Pharmacokinetics and Pharmacodynamics. - : SPRINGER/PLENUM PUBLISHERS. - 1573-8744 .- 1567-567X. ; 43, s. S88-S88 Konferensbidrag (övrigt vetenskapligt/konstnärligt)

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Typ av publikation: konferensbidrag (56)Ta bort avgränsningen

Typ av innehåll: refereegranskat (34); övrigt vetenskapligt/konstnärligt (22)

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