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- Bixo, Marie, 1957-
(författare)
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Ovarian steroids in rat and human brain : effects of different endocrine states
- 1987
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Ovarian steroid hormones are known to produce several different effects in the brain. In addition to their role in gonadotropin release, ovulation and sexual behaviour they also seem to affect mood and emotions, as shown in women with the premenstrual tension syndrome. Some steroids have the ability to affect brain excitability. Estradiol decreases the electroshock threshold while progesterone acts as an anti-convulsant and anaesthetic in both animals and humans. Several earlier studies have shown a specific uptake of several steroids in the animal brain but only a few recent studies have established the presence of steroids in the human brain.In the present studies, the dissections of rat and human brains were carried out macroscopically and areas that are considered to be related to steroid effects were chosen. Steroid concentrations were measured by radioimmunoassay after extraction and separation with celite chromatography. The accuracy and specificity of these methods were estimated.In the animal studies, immature female rats were treated with Pregnant Mare's Serum Gonadotropin (PMSG) to induce simultaneous ovulations. Concentrations of estradiol and progesterone were measured in seven brain areas pre- and postovulatory. The highest concentration of estradiol, pre- and postovulatory, was found in the hypothalamus and differences between the two cycle phases were detected in most brain areas. The preovulatory concentrations of progesterone were low and the highest postovulatory concentration was found in the cerebral cortex.In one study, the rats were injected with pharmacological doses of progesterone to induce "anaesthesia". High uptake of progesterone was found and a regional variation in the formation of 5<*-pregnane-3,20-dione in the brain with the highest ratio in the medulla oblongata.Concentrations of progesterone, 5a-pregnane-3*20-dione, estradiol and testosterone were determined in 17 brain areas of fertile compared to postmenopausal women. All steroids displayed regional differences in brain concentrations. Higher concentrations of estradiol and progesterone were found in the fertile compared to the postmenopausal women.In summary, these studies show that the concentrations of ovarian steroids in the brain are different at different endocrine states in both rats and humans and that there are regional differences in brain steroid distribution.
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| 2. |
- Sandman, Per-Olof, 1950-, et al.
(författare)
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Nutritional status and dietary intake in institutionalised patients with Alzheimer's disease and multifarct dementia
- 1987
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Ingår i: Journal of The American Geriatrics Society. - 0002-8614 .- 1532-5415. ; 35, s. 31-38
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Tidskriftsartikel (refereegranskat)abstract
- Nutritional status, dietary intake, weight change, and mortality were studied in a sample of severely demented, institutionalized patients. Dietary intake was registered during five days in two periods, five weeks apart. A weighing method was used. Nutritional status was assessed by anthropometric measurements (weight for height index, triceps skinfold thickness, arm muscle circumference) and determination of circulating proteins (albumin, transferrin, and prealbumin). Energy and/or protein malnutrition was found in 50% of the patients. The mean dietary intake was sufficient according to energy (2059 kcal/day), proteins, vitamins, and minerals. A comparison of patients with or without malnutrition showed no differences in dietary intake, diagnoses, age, length of hospital stay, or duration of illness. However, malnourished patients had had four times as many infectious periods treated by antibiotics as patients with no malnutrition. Thirty-nine of 44 patients lost weight during their hospital stay. There was no correlation between loss of weight, length of hospital stay, or duration of illness.
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| 3. |
- Steen, B., et al.
(författare)
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Body composition in the elderly estimated with an electrical impedance method.
- 1987
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Ingår i: Comprehensive gerontology. Section A, Clinical and laboratory sciences. - 0902-0071. ; 1:3, s. 102-105
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of the present study was to test the reliability and validity of a new electrical impedance method for estimating body composition in 35 healthy persons and patients in different sex and age groups, and to obtain basal data on the size of different body composition compartments in elderly individuals in health and disease. The reliability studies showed no significant differences with the new method in intraindividual comparisons before and after changing the positions of the electrodes, drinking of water, and overnight fasting, as well as at a double estimation on 2 consecutive days. The results with this method are compared to results from measurements of total body potassium and total body water, and from a four-compartment model technique using total body potassium and total body water. We conclude that the method has an acceptable reliability and validity and should be of great value not only in field studies but also in clinical practice. Data on body composition with the electrical impedance method are obtained from 147 individuals in different groups, namely healthy females, 80-81-year-old males, female patients from a nursing home, and patients of both sexes from a day care unit.
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