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| 2. |
- Risberg, Jarl, et al.
(författare)
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A new tomographic technique for absolute measurements of white and gray matter blood flow
- 2004
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Ingår i: Proceedings of the 8th Nordic Meeting in Neuropsychology, Turku, Finland, August 26–29, 2004, 85.
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Konferensbidrag (refereegranskat)abstract
- Objective. Most methods for measurements of the regional cerebral blood flow are unable to provide absolute blood flow values. Until now interest has been focused on measurement of the gray matter blood flow, while the white matter blood flow has been rather neglected. The aim of the present project was to develop and evaluate an improved method for reliable tomographic measurements of absolute white and gray matter blood flow Method. The new tomographic method (modified Xe-SPECT) is based on an extension of the period of 133Xe inhalation from one to eight minutes followed by 22 instead of four minutes of breathing of ambient air. This gives a markedly enhanced signal from the white matter and better basis for correct quantification of the blood flow. The arrival and clearance of the tracer are recorded by a three head gamma camera system that provides flow maps with a spatial resolution of about one cm. Results The new method has been evaluated in 33 healthy younger and older (around 70 years) subjects as well as in a group of elderly patients with organic dementia. Our preliminary findings indicate that new and clinically valuable information is obtained by the improved Xe-SPECT method.
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| 3. |
- Rothenberg, Elisabeth, 1960, et al.
(författare)
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Dietary intake and energy metabolism
- 2004
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Ingår i: To become old: The Gerontological and Geriatric Population Studies in Göteborg, Sweden 1971-2002 Editor: Bertil Steen. - Göteborg : Göteborg University. - 9163171821 ; , s. 41-44
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 6. |
- McCaddon, Andrew, et al.
(författare)
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Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease
- 2004
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Ingår i: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 17:3, s. 215-221
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Tidskriftsartikel (refereegranskat)abstract
- Isoforms of the vitamin B<sub>12</sub> carrier protein transcobalamin (TC) might influence its cellular availability and contribute to the association between disrupted single-carbon metabolism and Alzheimer’s disease (AD). We therefore investigated the relationships between the TC 776C>G (Pro259Arg) genetic polymorphism, total serum cobalamin and holo-TC levels, and disease onset in 70 patients with clinically diagnosed AD and 74 healthy elderly controls. TC 776C>G polymorphism was also determined for 94 histopathologically confirmed AD patients and 107 controls. Serum holo-TC levels were significantly higher in TC 776C homozygotes (p = 0.04). Kaplan-Meier survival functions differed between homozygous genotypes (Cox’s F-Test F(42, 46) = 2.1; p = 0.008) and between 776C homozygotes and heterozygotes (Cox’s F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study.
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| 7. |
- Wallin, Åsa, et al.
(författare)
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Five-year outcome of cholinergic treatment of Alzheimer's disease: Early response predicts prolonged time until nursing home placement, but does not alter life expectancy
- 2004
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Ingår i: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 18:2, s. 197-206
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Tidskriftsartikel (refereegranskat)abstract
- Fifty consecutive outpatients with Alzheimer’s disease (AD) received treatment with the cholinesterase inhibitor tacrine in an open longitudinal study. Assessments using Mini-Mental State Examination, Alzheimer’s Disease Assessment Scale – cognitive subscale, and a global rating were made at baseline and at 6, 12, 24, 36, 48 and 60 months. Three outcome groups were characterized: responders, unchanged and deteriorated. Additional outcome measures were time until nursing home placement, and mortality rate. At 6 months –75%, at 12 months –42%, at 24 months –20%, and after that 10% of the patients still on medication had improved or remained stable. The mortality rate did not differ between the outcome groups. Response to tacrine treatment at 6 or 12 months was found to predict a prolonged time until nursing home placement. No predictors for a positive treatment response could be identified at baseline.
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| 8. |
- Bauer, Betty, et al.
(författare)
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Right temporal lobe activation when listening to emotionally significant music
- 2004
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Ingår i: Applied Neuropsychology. - : Informa UK Limited. - 0908-4282 .- 1532-4826. ; 11:3, s. 161-166
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Tidskriftsartikel (refereegranskat)abstract
- The cerebral activation when normal elderly participants (6 women, 6 men, M age = 70 years) listened to self-selected emotionally significant music was investigated. Musical memories and preferences were discussed in an interview, and a piece of music with great emotional significance to the participant was selected and later played during measurement of the regional cerebral blood flow (rCBF). Measurements were made during silence, individually selected emotional music, and standard neutral music. The right temporal lobe showed a significant (p < .01) increase in rCBF when the emotional music was compared to silence. A temporal lobe asymmetry (right > left) during emotional music was also significant (p < .01). A decrease in the left prefrontal areas reached significance (p < .05) when standard music was compared to silence. For the emotional music, the right prefrontal area showed a decrease (p < .05). Emotional music thus activates right temporal and deactivates prefrontal regions in the right hemisphere.
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| 10. |
- Akner, Gunnar, 1953-
(författare)
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Geriatric medicine in Sweden : a study of the organisation, staffing and care production in 2000-2001
- 2004
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Ingår i: Age and Ageing. - : Oxford University Press (OUP). - 0002-0729 .- 1468-2834. ; 33:4, s. 338-341
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: the organisation of long-term medicine and geriatric medicine has undergone many changes during the last 15 years. The aim of this study is to gain an overall perspective of the present organisation of geriatric medicine in Sweden.DESIGN: questionnaire survey.METHODS: The Swedish Society for Geriatric Medicine and Gerontology, in collaboration with the Federation of County Councils and the Swedish Association of Local Authorities, sent out a survey to people in all county councils in Sweden. The subject of the survey was the speciality of geriatric medicine in the Swedish healthcare system, with regard to healthcare organisation, staffing and care production in 2000/2001.RESULTS: there were 52 separate geriatric units, 41 independent 'clinics' and 11 'sections' within other departments. There were a total of 3,101 geriatric inpatient beds. On average, there was one geriatric bed for every 799 individuals within the local population aged 65 years and over, with a 10-fold variation between counties. Four counties had no geriatric provision. The 'geriatric clinics' were mainly located in university towns and averaged 85 beds per clinic, again with a 10-fold variation. There were 604 established positions for doctors within geriatrics, of which 63% were at geriatric clinics. On average, the clinics had 16 positions each (of which 75% were filled with geriatric specialists) with 7 beds per doctor. The corresponding averages for nurses and paramedics could not be summarised due to organisational differences between the county councils. In general, there were very few nurses with specialist training in geriatric medicine.CONCLUSIONS: the field of geriatric medicine in Sweden is very heterogeneous regarding terminology, designations, structure, staffing and care production. There is no overall structural plan for the role of geriatric medicine in Swedish healthcare, with the desired close connection between content and dimensioning of geriatric specialist training and the practical organisation of the activities. The county councils designate geriatric medicine so differently that it is hardly possible to compare different geriatric facilities today. Considering how many patients at hospitals today are elderly and suffer from multiple illnesses, it is a major quality issue to ensure that these patients have access to geriatric specialists.
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