| 61. |
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| 62. |
- Nilsson, Karin, et al.
(författare)
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Role of impaired renal function as a cause of elevated plasma homocysteine concentration in psychogeriatric patients.
- 2002
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Ingår i: Scandinavian Journal of Clinical & Laboratory Investigation. - : Informa UK Limited. - 1502-7686 .- 0036-5513. ; 62:5, s. 9-385
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Tidskriftsartikel (refereegranskat)abstract
- In previous studies a high frequency of elevated plasma tHcy concentrations has been observed in psychogeriatric patients (40-50%), but the main cause of these increased concentrations could not be established with certainty. Impaired renal function could partly contribute to elevated plasma tHcy concentrations in psychogeriatric patients. Therefore, in the present study, cystatin C was used as a sensitive marker for glomerular filtration. A linear regression analysis including age, blood folate, serum cobalamin, serum cystatin C and serum creatinine showed that only serum creatinine (p<0.001) and blood folate (p<0.001) independently predicted plasma tHcy concentration. However, about 44% of the patients with elevated plasma tHcy concentrations had signs of reduced glomerular filtration rate, as judged by increased serum cystatin C, whereas only about 13% of the patients with normal concentrations of plasma tHcy had signs of reduced glomerular filtration rate. This finding indicates that renal impairment may to some extent contribute to the elevated plasma tHcy concentration, even though serum cystatin C did not independently predict plasma tHcy concentration.
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| 63. |
- Nilsson, Karin, et al.
(författare)
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Treatment of cobalamin deficiency in dementia, evaluated clinically and with cerebral blood flow measurements
- 2000
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Ingår i: Aging. - 0394-9532. ; 12:3, s. 199-207
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Tidskriftsartikel (refereegranskat)abstract
- We investigated the relation between cobalamin deficiency, clinical changes and brain function in dementia patients. On admittance to the clinic, 24 patients had cobalamin deficiency, and dementia with additional symptoms of delirium. During cobalamin supplementation, the patients underwent repeated regional cerebral blood flow (rCBF) studies, psychiatric evaluations, and in some cases assessment with MMSE and the Organic Brain Syndrome scale. Fifteen patients who showed mild to moderate dementia improved clinically, and also showed a concomitant increase in their general CBF after treatment. In contrast, 9 patients who were severely demented showed no obvious clinical improvement, and no general blood flow change, although some regional flow increases were seen in sensory motor areas. We conclude that symptoms which probably indicated superimposed delirium such as clouding of consciousness, disorientation and clinical fluctuation, responded to the vitamin B12 supplementation, while the underlying dementia condition remained basically unchanged. The clinical improvement was also mirrored in general and focal rCBF changes.
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| 64. |
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| 65. |
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| 66. |
- Persson, M., et al.
(författare)
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Validation of a dietary record routine in geriatric patients using doubly labelled water
- 2000
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Ingår i: European Journal of Clinical Nutrition. - : Springer Science and Business Media LLC. - 0954-3007 .- 1476-5640. ; 54:10, s. 789-796
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To validate a 7-day estimated dietary record routine with standardized portion sizes and household measuring in a clinical setting with the doubly labelled water (DLW) method as the reference method. Design: Energy expenditure was measured with deuterium (2H) and oxygen-18 (18O), and water loss was estimated by 2H dilution as part of the DLW measurements. Energy and water intake was measured with a 7 day dietary record. Setting: Five nursing home wards in Sweden. Subjects: Thirty-one geriatric patients with a mean age of 86y. Inclusion criteria were stable body weight, defined as a maximum change of ± 4% during the last 4 months of ± 2% during the last 2 months and without any acute illness. Results: The mean daily energy intake was 7.2 MJ (1727 kcal) and the mean daily energy expenditure was 6.7 MJ (1595 kcal). The mean daily water intake was 1787 ml and mean daily water loss assessed by labelled water was 1774 ml. Using the dietary record routine, the staff overestimated the patients' energy intake by 8% and water intake from food and beverages by < 1% compared to DLW. Conclusion: The 7 day dietary record routine based on standardized portion sizes and household measuring seems to be a valid method for assessing the intake of energy and fluids by geriatric patients.
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| 67. |
- Philpot, M, et al.
(författare)
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Barriers to the use of electroconvulsive therapy in the elderly: a European survey
- 2002
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Ingår i: European Psychiatry. - 1778-3585. ; 17:1, s. 41-45
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Tidskriftsartikel (refereegranskat)abstract
- A postal survey was carried out to determine the clinical and legal guidelines governing the use of electroconvulsive therapy (ECT) in the countries of the wider Europe. Respondents from 23 of the 33 countries returned completed questionnaires. Considerable variation was found in the availability of ECT, the frequency of its use and associated legal procedures. However, there was a broad consensus with regard to the clinical indications. Access to the treatment was most frequently limited by financial or other resource constraints, political or legal restrictions. (C) 2002 Editions scientifiques et medicales Elsevier SAS.
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| 68. |
- Risberg, Jarl, et al.
(författare)
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99mTC-HMPAO-SPECT related to clinical findings in patients with subjective experience of memory deficit
- 2004
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Ingår i: Proceedings of the 8th Nordic Meeting in Neuropsychology.
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Konferensbidrag (refereegranskat)abstract
- Objective. The aim was to evaluate cognitive impairments, psychiatric symptoms and cerebral blood flow (CBF) patterns in middle-aged and younger old patients with subjective experience of memory deficits. Methods. The CBF was measured by 99m-Tc-HMPAO-SPECT. The study group was heterogeneous with patients fulfilling criteria for dementia (n=13) and patients with mild cognitive impairment (MCI; n= 24) as well as with not verified cognitive impairment (Non-MCI; n=17). The MCI patients were subdivided into two groups. The MCI type 1 group (n=14) had isolated memory impairments while the MCI type 2 group (n=10) had memory impairments together with slight verbal and/or visuospatial disturbances. Results. The MCI type 1 group showed lower blood flow in the left middle/inferior gyrus and in parts of the left inferior parietal lobe compared to the Non-MCI group. The MCI type 2 group showed reductions in the left anterior medial temporal lobe as well as in parts of the posterior cingulate gyrus. The Non-MCI patients reported high incidence (70%) of long-lasting psychosocial stress. Conclusions. The combination of clinical and CBF data provides diagnostically meaningful information about regional brain dysfunction in patients with memory deficits.
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| 69. |
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| 70. |
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