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- Arvidsson, Susann, 1965-, et al.
(författare)
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Adult survivors’ perceptions of their childhood and the influences of being treated for acute lymphoblastic leukaemia with allogeneic hematopoietic stem cell transplantation as a child : A phenomenographic study
- 2024
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Ingår i: European Journal of Oncology Nursing. - Oxford : Elsevier. - 1462-3889 .- 1532-2122. ; 70
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Adults who had acute lymphoblastic leukaemia (ALL) as children and were treated with allogeneic hematopoietic stem cell transplantation (aHSCT) may have been affected in their lives due to several long-term complications. From a clinical point of view, it is of interest to study how survivors describe their perceptions of their childhood today. The aim was therefore to describe how adults perceived their childhood and the influences of being treated for ALL with aHSCT as a child.Method: Semi-structured telephone interviews were undertaken with 18 adults who had been treated for childhood ALL with aHSCT and were included in a national cohort of childhood ALL survivors, diagnosed between 1985 and 2007 at an age between 0 and 17 years. A phenomenographic analysis was used.Results: Three categories emerged: Feeling different, Feeling security and Feeling guilty. The informants felt that they had been different from other children but had felt security with the healthcare professionals and in care. They felt guilty because both their siblings’ and parents’ lives had been affected, but at the same time many perceived that they and their family members had become closer to one another.Conclusions: The results emphasised that adults who had been treated for childhood ALL with aHSCT were affected both in negative and positive ways during their childhood. This indicates the importance for early psychosocial care interventions directed to children during their treatment, but also the need for person-centred psychological care in long-term outpatient clinics. © 2024 The Authors. Published by Elsevier Ltd.
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| 3. |
- Islam, Tohidul, 1982, et al.
(författare)
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Novel ultrasensitive immunoassay for the selective quantification of tau oligomers and related soluble aggregates
- 2024
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Ingår i: ALZHEIMERS & DEMENTIA. - 1552-5260 .- 1552-5279.
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTIONTau aggregation into paired helical filaments and neurofibrillary tangles is characteristic of Alzheimer's disease (AD) and related disorders. However, biochemical assays for the quantification of soluble, earlier-stage tau aggregates are lacking. We describe an immunoassay that is selective for tau oligomers and related soluble aggregates over monomers.METHODSA homogeneous (single-antibody) immunoassay was developed using a novel anti-tau monoclonal antibody and validated with recombinant and brain tissue-derived tau.RESULTSThe assay signals were concentration dependent for recombinant tau aggregates in solution but not monomers, and recognized peptides within, but not outside, the aggregation-prone microtubule binding region. The signals in inferior and middle frontal cortical tissue homogenates increased with neuropathologically determined Braak staging, and were higher in insoluble than soluble homogenized brain fractions. Autopsy-verified AD gave stronger signals than other neurodegenerative diseases.DISCUSSIONThe quantitative oligomer/soluble aggregate-specific assay can identify soluble tau aggregates, including oligomers, from monomers in human and in vitro biospecimens.Highlights The aggregation of tau to form fibrils and neurofibrillary tangles is a key feature of Alzheimer's disease. However, biochemical assays for the quantification of oligomers/soluble aggregated forms of tau are lacking. We developed a new assay that preferentially binds to soluble tau aggregates, including oligomers and fibrils, versus monomers. The assay signal increased corresponding to the total protein content, Braak staging, and insolubility of the sequentially homogenized brain tissue fractions in an autopsy-verified cohort. The assay recognized tau peptides containing the microtubule binding region but not those covering the N- or C-terminal regions only.
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| 5. |
- Olsson, Maria, 1964, et al.
(författare)
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Co-creation of a digital platform for peer support in a community of adolescent and young adult patients during and after cancer
- 2024
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Ingår i: European Journal of Oncology Nursing. - 1462-3889.
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Tidskriftsartikel (refereegranskat)abstract
- Background Adolescents and young adults (AYAs) diagnosed with cancer report psychological challenges and social isolation. Peer support has been shown to be a valuable resource for coping with these experiences. Aim The aim of this study was through co-creation map the needs for peer support among AYA cancer patients in Sweden; and building on these results to develop and test a prototype of a digital tool for peer support. Method The study was conducted in co-creation in a team consisting of AYA cancer patients, researchers, and a health tech company in Sweden. Through interviews the needs for emotional support were investigated. Based on this information, a prototype of a digital platform was co-created by the team. The platform was tested and evaluated through an online survey and follow-up interviews as part of the development process. Results AYAs expressed feelings of loneliness and a desire to process their cancer experiences with peers. A prerequisite for a digital platform for peer support was the assurance of a high degree of security. Piloting the prototype, 87% reported feeling secure, all participants found it valuable to interact with peers on the platform. In the follow-up interviews, AYAs emphasizing the need to simplify this process while maintaining stringent security measures. Conclusion Co-creating tools for support with AYAs ensures relevance and usability. A secure digital platform for peer support represents a complement to other existing forms of support. The presence of moderators was found to enhance security. Further development of the platform's log-in procedure is necessary.
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| 7. |
- Olsson, Maria, Lektor
(författare)
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Risk eller frisk? Tvärprofessionell samverkan för att förebygga att barn i förskola och skola hamnar i svårigheter
- 2024
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Ingår i: Utbildning och lärande. - 1653-0594. ; 18:1, s. 1-18
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Tidskriftsartikel (refereegranskat)abstract
- This article contributes knowledge regarding professionals’ expectations and conceptions of what initiatives in pedagogical practice, multiprofessional cooperation for supporting children “at risk”, can generate or has generated. The data derive from semi-structured interviews with professionals involved in a project in a Swedish municipality that aimed by means of improved multi-professional collaboration to prevent children from getting into difficulties. In this article, Billig’s concept of ideological dilemmas was used as theoretical framework, and the data analysis was inspired by qualitative content analysis. The presented ideological dilemmas – rhetoric versus practice and the individual versus the collective – relate to contrasting overarching logics associated with education and social services: promoting all children’s health and development versus treating individuals’ potential deficiencies. This article suggests that discussions about the intentions of multiprofessional collaboration need to be held when opposing positions can be articulated. Such discussions, based on professionals’ experiences and knowledge, may lead to the development of multiprofessional collaboration.
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| 8. |
- Gunnarsson, Ann-Charlotte, 1964-
(författare)
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Vuxeneleven i fokus : Att utforma metoder för individanpassad undervisning i en forskningscirkel vid Komvux
- 2023
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Denna studie tillhör deltagarorienterad forskning (PAR) i form av en forskningscirkel. Syftet var att beskriva och analysera en forskningscirkels kunskapsutveckling både gällande dess process och dess innehåll. Deltagarna i cirkeln var nio lärare som arbetar vid en komvuxskola och de undervisar vuxenelever i ämnena SFI, SVA och engelska. Forskningscirkelns fokus har varit frågor som gäller individanpassad undervisning inom komvuxutbildningar. I cirkeln har empiriska data kommit fram genom att låta deltagarna berätta sina livsberättelser om individanpassad undervisning och i gruppsamtal prata om individanpassad undervisning. I en växelverkan mellan deltagarnas erfarenheter om individanpassad undervisning och tidigare forskning inom detta område, arbetade vi i cirkeln fram metoder för individanpassad undervisning inom komvuxutbildningar. Deltagarna prövade dessa metoder i undervisningen. Metoderna som var utformade för individanpassad undervisning var både vitt och övergripande utformade, vilket var positivt på grund av att lärarna kunde anpassa metoderna och arbetssätten till varje elevgrupp och till enskilda vuxenelever. Resultatet visar att individanpassad undervisning bör utformas som individuell undervisning, en till en undervisning, mellan lärare och vuxenelev. Då kan vuxeneleven få individuell hjälp med studierna och eleven kan få arbetsuppgifter som är individuellt anpassad till hens förmåga att studera. Det har också framkommit att, det är viktigt att undervisningen är utformad utifrån relationell undervisning, vilket innebär att vuxeneleven både får möta lärare och andra elever under studiernas gång. Det innebär olika undervisningssätt som både är individanpassade, samtidigt som de utgår från en relationell undervisning. Det har framkommit i studien att relationell undervisning är särskilt viktigt i språkundervisningen. Det har också uppmärksammats individanpassade metoder som utgår från digital undervisning både inom individuell undervisning och relationell undervisning. I studien lyftes fram olika arbetssätt som utgår från digital undervisning.
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| 9. |
- Mak, Jonathan K. L., et al.
(författare)
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Two Years with COVID-19 : The Electronic Frailty Index Identifies High-Risk Patients in the Stockholm GeroCovid Study
- 2023
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Ingår i: Gerontology. - : S. Karger. - 0304-324X .- 1423-0003. ; 69:4, s. 396-405
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Frailty, a measure of biological aging, has been linked to worse COVID-19 outcomes. However, as the mortality differs across the COVID-19 waves, it is less clear whether a medical record-based electronic frailty index (eFI) that we have previously developed for older adults could be used for risk stratification in hospitalized COVID-19 patients. Objectives: The aim of the study was to examine the association of frailty with mortality, readmission, and length of stay in older COVID-19 patients and to compare the predictive accuracy of the eFI to other frailty and comorbidity measures. Methods: This was a retrospective cohort study using electronic health records (EHRs) from nine geriatric clinics in Stockholm, Sweden, comprising 3,980 COVID-19 patients (mean age 81.6 years) admitted between March 2020 and March 2022. Frailty was assessed using a 48-item eFI developed for Swedish geriatric patients, the Clinical Frailty Scale, and the Hospital Frailty Risk Score. Comorbidity was measured using the Charlson Comorbidity Index. We analyzed in-hospital mortality and 30-day readmission using logistic regression, 30-day and 6-month mortality using Cox regression, and the length of stay using linear regression. Predictive accuracy of the logistic regression and Cox models was evaluated by area under the receiver operating characteristic curve (AUC) and Harrell's C-statistic, respectively. Results: Across the study period, the in-hospital mortality rate decreased from 13.9% in the first wave to 3.6% in the latest (Omicron) wave. Controlling for age and sex, a 10% increment in the eFI was significantly associated with higher risks of in-hospital mortality (odds ratio = 2.95; 95% confidence interval = 2.42-3.62), 30-day mortality (hazard ratio [HR] = 2.39; 2.08-2.74), 6-month mortality (HR = 2.29; 2.04-2.56), and a longer length of stay (beta-coefficient = 2.00; 1.65-2.34) but not with 30-day readmission. The association between the eFI and in-hospital mortality remained robust across the waves, even after the vaccination rollout. Among all measures, the eFI had the best discrimination for in-hospital (AUC = 0.780), 30-day (Harrell's C = 0.733), and 6-month mortality (Harrell's C = 0.719). Conclusion: An eFI based on routinely collected EHRs can be applied in identifying high-risk older COVID-19 patients during the continuing pandemic.
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| 10. |
- Olsson, Maria, Lektor, et al.
(författare)
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Between an educational task and an idea for treatment : multiprofessional collaboration for supporting children "at risk" – a coordinator role in pedagogical practice
- 2023
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Ingår i: Scandinavian Journal of Educational Research. - : Routledge. - 0031-3831 .- 1470-1170.
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Tidskriftsartikel (refereegranskat)abstract
- This article contributes knowledge regarding professionals’ experiences, conceptions, and expectations of a coordinator role in preschools/schools while multiprofessionally collaborating for supporting children "at risk". Data were collected via semi-structured interviews with professionals involved in a project in a Swedish municipality intended to prevent children from getting into difficulties. Procedures for thematic analysis were followed, and Billig’s ideological dilemmas were used as a methodological tool. A coordinator role, assigned to head teachers, emerges as tense where dilemmas need to be addressed. The dilemmas are related to opposed, overarching ideas – education for "all" versus treatment for specific children – which require coordination. This article suggests that dialogues between actors need to be held when opposite positions can be articulated. To initiate and maintain such dialogues, a coordinator role is important.
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