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  • Roberson-Nay, Roxann, et al. (författare)
  • Longitudinal Stability of Genetic and Environmental Influences on Irritability: From Childhood to Young Adulthood.
  • 2015
  • Ingår i: The American journal of psychiatry. - Stockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics. - 0002-953X .- 1535-7228.
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: Little is known about genetic influences on juvenile irritability and whether such influences are developmentally stable and/or dynamic. This study examined the temporal pattern of genetic and environmental effects on irritability using data from a prospective, four-wave longitudinal twin study. METHOD: Parents and their twin children (N=2,620 children) from the Swedish Twin Study of Child and Adolescent Development reported on the children's irritability, defined using a previously identified scale from the Child Behavior Checklist. RESULTS: Genetic effects differed across the sexes, with males exhibiting increasing heritability from early childhood through young adulthood and females exhibiting decreasing heritability. Genetic innovation was also more prominent in males than in females, with new genetic risk factors affecting irritability in early and late adolescence for males. Shared environment was not a primary influence on irritability for males or females. Unique, nonshared environmental factors suggested strong effects early for males followed by an attenuating influence, whereas unique environmental factors were relatively stable for females. CONCLUSIONS: Genetic effects on irritability are developmentally dynamic from middle childhood through young adulthood, with males and females displaying differing patterns. As males age, genetic influences on irritability increase while nonshared environmental influences weaken. Genetic contributions are quite strong in females early in life but decline in importance with age. In girls, nonshared environmental influences are fairly stable throughout development.
  • Viktorin, Alexander, et al. (författare)
  • Heritability of Perinatal Depression and Genetic Overlap With Nonperinatal Depression.
  • 2016
  • Ingår i: The American journal of psychiatry. - Stockholm : Karolinska Institutet, Dept of Medical Epidemiology and Biostatistics. - 1535-7228. ; 173:2, s. 158-165
  • Tidskriftsartikel (refereegranskat)abstract
    • The authors investigated the relative importance of genetic and environmental influences on perinatal depression, and the genetic overlap between perinatal depression and nonperinatal depression.
  • Anckarsäter, Henrik, 1966, et al. (författare)
  • The impact of ADHD and autism spectrum disorders on temperament, character, and personality development.
  • 2006
  • Ingår i: The American Journal of Psychiatry. - : American Psychiatric Association. - 0002-953X .- 1535-7228. ; 163:7, s. 1239-1244
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: The authors describe personality development and disorders in relation to symptoms of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders. METHOD: Consecutive adults referred for neuropsychiatric investigation (N=240) were assessed for current and lifetime ADHD and autism spectrum disorders and completed the Temperament and Character Inventory. In a subgroup of subjects (N=174), presence of axis II personality disorders was also assessed with the Structured Clinical Interview for DSM-IV Personality Disorders (SCID-II). RESULTS: Patients with ADHD reported high novelty seeking and high harm avoidance. Patients with autism spectrum disorders reported low novelty seeking, low reward dependence, and high harm avoidance. Character scores (self-directedness and cooperativeness) were extremely low among subjects with neuropsychiatric disorders, indicating a high overall prevalence of personality disorders, which was confirmed with the SCID-II. Cluster B personality disorders were more common in subjects with ADHD, while cluster A and C disorders were more common in those with autism spectrum disorders. The overlap between DSM-IV personality disorder categories was high, and they seem less clinically useful in this context. CONCLUSIONS: ADHD and autism spectrum disorders are associated with specific temperament configurations and an increased risk of personality disorders and deficits in character maturation.
  • Araya, Ricardo, et al. (författare)
  • Cost-effectiveness of a primary care treatment program for depression in low-income women in Santiago, Chile.
  • 2006
  • Ingår i: American Journal of Psychiatry. - 0002-953X .- 1535-7228. ; 163:8, s. 1379-87
  • Tidskriftsartikel (refereegranskat)abstract
    • OBJECTIVE: The authors compared the incremental cost-effectiveness of a stepped-care, multicomponent program with usual care for the treatment of depressed women in primary care in Santiago, Chile.METHOD: A cost-effectiveness study was conducted of a previous randomized controlled trial involving 240 eligible women with DSM-IV major depression who were selected from a consecutive sample of adult women attending primary care clinics. The patients were randomly allocated to usual care or a multicomponent stepped-care program led by a nonmedical health care worker. Depression-free days and health care costs derived from local sources were assessed after 3 and 6 months. A health service perspective was used in the economic analysis.RESULTS: Complete data were determined for 80% of the randomly assigned patients. After we adjusted for initial severity, women receiving the stepped-care program had a mean of 50 additional depression-free days over 6 months relative to patients allocated to usual care. The stepped-care program was marginally more expensive than usual care (an extra 216 Chilean pesos per depression-free day). There was a 90% probability that the incremental cost of obtaining an extra depression-free day with the intervention would not exceed 300 pesos (1.04 US dollars).CONCLUSIONS: The stepped-care program was significantly more effective and marginally more expensive than usual care for the treatment of depressed women in primary care. Small investments to improve depression appear to yield larger gains in poorer environments. Simple and inexpensive treatment programs tested in developing countries might provide good study models for developed countries.
  • Backman, L, et al. (författare)
  • Age-related cognitive deficits mediated by changes in the striatal dopamine system
  • 2000
  • Ingår i: AMERICAN JOURNAL OF PSYCHIATRY. - : AMER PSYCHIATRIC PRESS, INC. - 0002-953X. ; 157:4, s. 635-637
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective: The study examined the influence of losses in dopaminergic function on age-related cognitive deficits. Method: Eleven healthy subjects (21-68 years of age) completed a set of cognitive tasks used to assess perceptual speed and episodic memory.
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