Search: L773:0012 1797 OR L773:1939 327X
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Effects of Gastric ...
Effects of Gastric Bypass Surgery on the Brain : Simultaneous Assessment of Glucose Uptake, Blood Flow, Neural Activity, and Cognitive Function During Normo- and Hypoglycemia
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- Almby, Kristina E. (author)
- Uppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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- Lundqvist, Martin H. (author)
- Uppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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- Abrahamsson, Niclas, 1976- (author)
- Uppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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- Kvernby, Sofia (author)
- Uppsala universitet,Radiologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Fahlström, Markus (author)
- Uppsala universitet,Radiologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Pereira, Maria J., 1981- (author)
- Uppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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- Gingnell, Malin, 1982- (author)
- Uppsala universitet,Institutionen för psykologi,Cervenka: Psykiatri,Department of Neurosciences and Department of Psychology, Uppsala University, Uppsala, Sweden
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- Karlsson, Anders, 1945- (author)
- Uppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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- Fanni, Giovanni (author)
- Uppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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- Sundbom, Magnus (author)
- Uppsala universitet,Gastrointestinalkirurgi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Wiklund, Urban (author)
- Umeå universitet,Radiofysik,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.
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- Haller, Sven (author)
- Uppsala universitet,Radiologi,Univ Geneva, Fac Med, Geneva, Switzerland.,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; Faculty of Medicine, University of Geneva, Geneva, Switzerland
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- Lubberink, Mark (author)
- Uppsala universitet,Radiologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Wikström, Johan, 1964- (author)
- Uppsala universitet,Radiologi,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Eriksson, Jan (author)
- Uppsala universitet,Klinisk diabetologi och metabolism,Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2021-03-04
- 2021
- English.
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In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 70:6, s. 1265-1277
- Related links:
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https://diabetes.dia...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
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- While Roux-en-Y gastric bypass (RYGB) surgery in obese individuals typically improves glycemic control and prevents diabetes, it also frequently causes asymptomatic hypoglycemia. Previous work showed attenuated counterregulatory responses following RYGB. The underlying mechanisms as well as the clinical consequences are unclear. In this study, 11 subjects without diabetes with severe obesity were investigated pre- and post-RYGB during hyperinsulinemic normo-hypoglycemic clamps. Assessments were made of hormones, cognitive function, cerebral blood flow by arterial spin labeling, brain glucose metabolism by F-18-fluorodeoxyglucose (FDG) positron emission tomography, and activation of brain networks by functional MRI. Post- versus presurgery, we found a general increase of cerebral blood flow but a decrease of total brain FDG uptake during normoglycemia. During hypoglycemia, there was a marked increase in total brain FDG uptake, and this was similar for post- and presurgery, whereas hypothalamic FDG uptake was reduced during hypoglycemia. During hypoglycemia, attenuated responses of counterregulatory hormones and improvements in cognitive function were seen postsurgery. In early hypoglycemia, there was increased activation post- versus presurgery of neural networks in brain regions implicated in glucose regulation, such as the thalamus and hypothalamus. The results suggest adaptive responses of the brain that contribute to lowering of glycemia following RYGB, and the underlying mechanisms should be further elucidated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
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Diabetes
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- By the author/editor
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Almby, Kristina ...
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Lundqvist, Marti ...
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Abrahamsson, Nic ...
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Kvernby, Sofia
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Fahlström, Marku ...
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Pereira, Maria J ...
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Gingnell, Malin, ...
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Karlsson, Anders ...
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Fanni, Giovanni
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Sundbom, Magnus
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Wiklund, Urban
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Haller, Sven
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Lubberink, Mark
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Wikström, Johan, ...
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Eriksson, Jan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Diabetes
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Uppsala University
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Umeå University