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Cancer as a risk fa...
Cancer as a risk factor for long-term cognitive deficits and dementia.
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Hefling, L A (author)
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Meyerowitz, B E (author)
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- Hall, P (author)
- Karolinska Institutet
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- Lichtenstein, P (author)
- Karolinska Institutet
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- Johansson, Boo (author)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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Pedersen, Nancy L. (author)
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Gatz, Margaret (author)
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Heflin, LH (author)
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(creator_code:org_t)
- 2005-06-01
- 2005
- English.
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In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 1460-2105 .- 0027-8874. ; 97:11, s. 854-856
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https://doi.org/10.1...
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Abstract
Subject headings
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- Previous studies have shown that cancer survivors frequently experience short-term cognitive deficits, but it is unknown how long these deficits last or whether they worsen over time. Using a co-twin control design, the cognitive function of 702 cancer survivors aged 65 years and older was compared with that of their cancer-free twins. Dementia rates were also compared in 486 of the twin pairs discordant for cancer. Cancer survivors overall, as well as individuals who had survived cancer for 5 or more years before cognitive testing, were more likely than their co-twins to have cognitive dysfunction (odds ratio [OR] = 2.10, 95% confidence interval [CI] = 1.36 to 3.24; P<.001; and OR = 2.71, 95% CI = 1.47 to 5.01; P<.001, respectively). Cancer survivors were also twice as likely to be diag-nosed with dementia as their co-twins, but this odds ratio did not reach statisti-cal significance (OR = 2.0, 95% CI = 0.86 to 4.67; P = .10). These results suggest that cancer patients are at increased risk for long-term cognitive dysfunction compared with individuals who have never had cancer, even after controlling for the influence of genetic factors and rearing environment.
Subject headings
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- Cancer
- cognition
- elderly
Publication and Content Type
- ref (subject category)
- art (subject category)
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