| 1. |
- Fored, C. M., et al.
(author)
-
Acetaminophen, aspirin, and chronic renal failure
- 2001
-
In: New England Journal of Medicine. - Waltham, USA : Massachusetts Medical Society. - 0028-4793 .- 1533-4406. ; 345:25, s. 1801-1808
-
Journal article (peer-reviewed)abstract
- Background: Several epidemiologic studies have demonstrated an association between heavy consumption of nonnarcotic analgesics and the occurrence of chronic renal failure, but it is unclear which is the cause and which is the effect.Methods: In a nationwide, population-based, case-control study of early-stage chronic renal failure in Sweden, face-to-face interviews were conducted with 926 patients with newly diagnosed renal failure and 998 control subjects, of whom 918 and 980, respectively, had complete data. We used logistic-regression models to estimate the relative risks of disease-specific types of chronic renal failure associated with the use of various analgesics.Results: Aspirin and acetaminophen were used regularly by 37 percent and 25 percent, respectively, of the patients with renal failure and by 19 percent and 12 percent, respectively, of the controls. Regular use of either drug in the absence of the other was associated with an increase by a factor of 2.5 in the risk of chronic renal failure from any cause. The relative risks rose with increasing cumulative lifetime doses, rose more consistently with acetaminophen use than with aspirin use, and were increased for most disease-specific types of chronic renal failure. When we disregarded the recent use of analgesics, which could have occurred in response to antecedents of renal disease, the associations were only slightly attenuated.Conclusions: Our results are consistent with the existence of exacerbating effects of acetaminophen and aspirin on chronic renal failure. However, we cannot rule out the possibility of bias due to the triggering of analgesic consumption by predisposing conditions.
|
|
| 2. |
|
|
| 3. |
- Hansson, LE, et al.
(author)
-
The risk of stomach cancer in patients with gastric or duodenal ulcer disease
- 1996
-
In: NEW ENGLAND JOURNAL OF MEDICINE. - : MASS MEDICAL SOC. - 0028-4793. ; 335:4, s. 242-249
-
Journal article (peer-reviewed)abstract
- Background Helicobacter pylori infection, now considered to be a cause of gastric cancer, is also strongly associated with gastric and duodenal ulcer disease. The discovery of these relations has brought the long-controversial connection between peptic ul
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Lagergren, J, et al.
(author)
-
Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma
- 1999
-
In: NEW ENGLAND JOURNAL OF MEDICINE. - : MASS MEDICAL SOC. - 0028-4793. ; 340:11, s. 825-831
-
Journal article (peer-reviewed)abstract
- Background The causes of adenocarcinomas of the esophagus and gastric cardia are poorly understood. We conducted an epidemiologic investigation of the possible association between gastroesophageal reflux and these tumors. Methods We performed a nationwide
|
|
