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Träfflista för sökning "L773:0340 6997 ;pers:(Strand Sven Erik)"

Sökning: L773:0340 6997 > Strand Sven Erik

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1.
  • Rydén, Stefan, et al. (författare)
  • A scintillation camera technique for measurements of the reticuloendothelial function -Comparison of different methods for measuring RES function
  • 1982
  • Ingår i: European Journal Of Nuclear Medicine. - 0340-6997. ; 7, s. 16-21
  • Tidskriftsartikel (refereegranskat)abstract
    • A highly standardized 99mTc-sulphur colloid was used to evaluate reticuloendothelial system (RES)-function in the normal rat and after RE blockade by gelatin (Haemaccel). Activity distribution in the animals was measured with a scintillation camera technique. Total uptake of activity in the liver was estimated. From the time-activity curves over the liver, the phagocytic index (kphag) was evaluated. Estimation of the uptake rate of the labelled colloid into the liver and into other parts of the RES was also performed using a twocompartment model. Different methods of evaluation of RE function were compared. It was shown that for a proper estimation of the RE function, the whole uptake curve must be considered. Gelatin (Haemaccel) significantly reduced the total colloid uptake by the liver. The colloid uptake rate into the liver was also significantly reduced. Liver specimens after colloid injection were examined by light and electron microscopy showing vacuolation of hepatocytes and sinusoidal cells probably due to pinocytosis. The technique described enables functional studies of the RES. It has the advantage of noninvasive registrations and is based on the same technical facilities as used for routine liver scintigraphy.
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2.
  • Strand, Sven Erik, et al. (författare)
  • The dual photopeak-area method applied to scintillation camera measurements of effective depth and activity of in vivo 123I-distributions
  • 1977
  • Ingår i: European Journal Of Nuclear Medicine. - 0340-6997. ; 2:2, s. 121-128
  • Tidskriftsartikel (refereegranskat)abstract
    • Attenuation curves and photopeak ratios of 159 keV and 28 keV phtons emitted in the decay of 123I have been studied using a scintillation camera equipped with an extra ADC for recording the pulse height distribution of the energy signal. Cavities of various sizes containing 123I-solution were placed at different depths in a water phantom in order to vary the effective depth, i.e., the thickness of attenuating material above the cavity plus the distance to the centre of activity in the cavity. The centre of activity varies with the distribution of activity in the cavity, size of cavity, and the effective attenuation coefficient derived from the attenuation curves. From the photopeak ratio an average effective depth is determined which can be used for calculating the attenuation correction factor. The dual photopeak ratio has been used in clinical evaluation of thyroid 123I uptake measurements where effective depths ranging from 21 to 43 mm were obtained for the activity in the thyroid. Applications of the photopeak ratio method for renography with 123I-hippuran and blood flow studies using 133Xe or 127Xe and studies with many other radionuclides are also discussed.
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