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Sökning: L773:0735 0414 OR L773:1464 3502 > Helander A

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Numrering	Referens	Omslagsbild	Hitta
1.	Beck, O, et al. (författare) Biomarkers to disclose recent intake of alcohol: potential of 5-hydroxytryptophol glucuronide testing using new direct UPLC-tandem MS and ELISA methods 2007 Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 0735-0414 .- 1464-3502. ; 42:4, s. 321-325 Tidskriftsartikel (refereegranskat)
2.	Bendtsen, P, et al. (författare) Urinary excretion of methanol and 5-hydroxytryptophol as biochemical markers of recent drinking in the hangover state 1998 Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 0735-0414 .- 1464-3502. ; 33:4, s. 431-438 Tidskriftsartikel (refereegranskat)
3.	Bergstrom, JP, et al. (författare) Clinical characteristics of carbohydrate-deficient transferrin (%disialotransferrin) measured by HPLC: sensitivity, specificity, gender effects, and relationship with other alcohol biomarkers 2008 Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 1464-3502 .- 0735-0414. ; 43:4, s. 436-441 Tidskriftsartikel (refereegranskat)
4.	Bottcher, M, et al. (författare) Evaluation of a new immunoassay for urinary ethyl glucuronide testing 2008 Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 1464-3502 .- 0735-0414. ; 43:1, s. 46-48 Tidskriftsartikel (refereegranskat)
5.	Dahl, H, et al. (författare) Urinary ethyl glucuronide and ethyl sulfate testing for detection of recent drinking in an outpatient treatment program for alcohol and drug dependence 2011 Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 1464-3502 .- 0735-0414. ; 46:3, s. 278-282 Tidskriftsartikel (refereegranskat)
6.	Dahl, H, et al. (författare) Urinary ethyl glucuronide and ethyl sulfate testing for recent drinking in alcohol-dependent outpatients treated with acamprosate or placebo 2011 Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 1464-3502 .- 0735-0414. ; 46:5, s. 553-557 Tidskriftsartikel (refereegranskat)
7.	Erim, Y, et al. (författare) Feasibility and Acceptability of an Alcohol Addiction Therapy Integrated in a Transplant Center for Patients Awaiting Liver Transplantation 2016 Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 1464-3502 .- 0735-0414. ; 51:1, s. 40-46 Tidskriftsartikel (refereegranskat)
8.	Helander, A, et al. (författare) Biochemical markers of alcohol use and abuse: experiences from the Pilot Study of the WHO/ISBRA Collaborative Project on state and trait markers of alcohol. International Society for Biomedical Research on Alcoholism 1997 Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 0735-0414 .- 1464-3502. ; 32:2, s. 133-144 Tidskriftsartikel (refereegranskat)
9.	Helander, A, et al. (författare) Detection times for urinary ethyl glucuronide and ethyl sulfate in heavy drinkers during alcohol detoxification 2009 Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 1464-3502 .- 0735-0414. ; 44:1, s. 55-61 Tidskriftsartikel (refereegranskat)
10.	Helander, A, et al. (författare) Dose-Response Characteristics of the Alcohol Biomarker Phosphatidylethanol (PEth)-A Study of Outpatients in Treatment for Reduced Drinking 2019 Ingår i: Alcohol and alcoholism (Oxford, Oxfordshire). - : Oxford University Press (OUP). - 1464-3502 .- 0735-0414. ; 54:6, s. 567-573 Tidskriftsartikel (refereegranskat)abstract AimMeasurement of whole-blood phosphatidylethanol (PEth) offers high sensitivity and specificity as alcohol biomarker. A remaining issue of importance for the routine application is to better establish the relationship between PEth concentration and amount and duration of drinking.MethodsThe study included 36 subjects (32–83 years) voluntarily attending outpatient treatment for reduced drinking. At ~ 3- to 4-week intervals, they provided a diary on their daily alcohol intake and gave blood samples for measurement of PEth and carbohydrate-deficient transferrin (CDT). Whole-blood PEth 16:0/18:1 was measured by liquid chromatography-tandem mass spectrometry and serum CDT (%disialotransferrin) by high-performance liquid chromatography.ResultsAt start, the self-reported past 2-week alcohol intake ranged 0–1260 (median 330) g ethanol, the PEth 16:0/18:1 concentration ranged 0.05–1.20 (median 0.23) μmol/L, and the CDT value ranged 0.7–13.0% (median 1.5%). At the final sampling after 5–20 (median 12) weeks, neither reported alcohol intake nor PEth and CDT levels differed significantly from the starting values. The PEth concentration showed best association with past 2-week drinking, followed by for intake in the next last week. The changes in PEth concentration vs past 2-week alcohol intake between two successive tests revealed that an increased ethanol intake by ~ 20 g/day elevated the PEth concentration by on average ~ 0.10 μmol/L, and vice versa for decreased drinking.ConclusionsThe PEth concentration correlated well with past weeks alcohol intake, albeit with a large inter-individual scatter. This indicates that it is possible to make only approximate estimates of drinking based on a single PEth value, implying risk for misclassification between moderate and heavy drinking.

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Typ av publikation: tidskriftsartikel (22)

Typ av innehåll: refereegranskat (22)

Författare/redaktör: Helander, A (22)Ta bort avgränsningen; Beck, O (5); Bottcher, M. (4); Dahl, H (4); Stephanson, N (2); Dahmen, N (2); visa fler...; Borg, S. (2); Fehr, C (2); Hermansson, U (2); CARLSSON, AV (2); Lindner, M. (1); Kiianmaa, K (1); CHRISTOPHERSEN, AS (1); MORLAND, J (1); Fors, M. (1); Klein, C. (1); Paul, A (1); Franck, J (1); Hammarberg, A (1); Salaspuro, M (1); Müller, C. (1); Neumann, T (1); Brandt, L (1); Salmela, K (1); Huss, A (1); Villén, T (1); Signell, P (1); Erim, Y (1); Jones, AW (1); Bendtsen, P (1); Zheng, YF (1); Spies, C (1); Bergstrom, JP (1); Soyka, M (1); Saunders, JB (1); Tabakoff, B (1); Hillgren, K (1); Domke, I (1); van Pelt, J (1); Schwarz, MJ (1); Springer, B (1); Weigl, G (1); Li, TK (1); Mayr, A. (1); Grant, B. (1); Schieber, K (1); Beckebaum, S (1); Ronnberg, S (1); Sarkola, T (1); Balant, L (1); visa färre...

Lärosäte: Karolinska Institutet (22)

Språk: Engelska (22)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (1)

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