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Early environmental risk factors for neurodevelopmental disorders - a systematic review of twin and sibling studies
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- Carlsson, Torkel (författare)
- Karolinska Institutet
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Molander, Felix (författare)
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- Taylor, Mark J (författare)
- Karolinska Institutet
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- Jonsson, Ulf, 1974- (författare)
- Karolinska Institutet,Uppsala universitet,Ramklint: Barn- och ungdomspsykiatri,Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden;Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden Child and Adolescent Psychiatry, Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden
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- Bölte, Sven (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Cambridge University Press, 2021
- 2021
- Engelska.
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Ingår i: Development and psychopathology (Print). - : Cambridge University Press. - 0954-5794 .- 1469-2198. ; 33:4, s. 1448-1495
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- While neurodevelopmental disorders (NDDs) are highly heritable, several environmental risk factors have also been suggested. However, the role of familial confounding is unclear. To shed more light on this, we reviewed the evidence from twin and sibling studies. A systematic review was performed on case control and cohort studies including a twin or sibling within-pair comparison of neurodevelopmental outcomes, with environmental exposures until the sixth birthday. From 7,315 screened abstracts, 140 eligible articles were identified. After adjustment for familial confounding advanced paternal age, low birth weight, birth defects, and perinatal hypoxia and respiratory stress were associated with autism spectrum disorder (ASD), and low birth weight, gestational age and family income were associated with attention-deficit/hyperactivity disorder (ADHD), categorically and dimensionally. Several previously suspected factors, including pregnancy-related factors, were deemed due to familial confounding. Most studies were conducted in North America and Scandinavia, pointing to a global research bias. Moreover, most studies focused on ASD and ADHD. This genetically informed review showed evidence for a range of environmental factors of potential casual significance in NDDs, but also points to a critical need of more genetically informed studies of good quality in the quest of the environmental causes of NDDs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- confounding factors
- environmental exposure
- neurodevelopmental disorders
- systematic review
- twin and sibling studies
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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