Search: L773:0959 4965
> Natural sciences >
The immune modulato...
The immune modulator Linomide prevents neuronal death in injured peripheral nerves of the mouse
-
- Ekström, Per (author)
- Lund University,Lunds universitet,Retinal degeneration: Molekylär patologi,Forskargrupper vid Lunds universitet,Retinal degeneration: Molecular Pathology,Lund University Research Groups
-
Hedlund, Gunnar (author)
-
Karlsson, Jenny (author)
-
show more...
-
Andersson, Gunnar (author)
-
show less...
-
(creator_code:org_t)
- 1998
- 1998
- English 5 s.
-
In: NeuroReport. - 0959-4965. ; 9:7, s. 1337-1341
- Related links:
-
https://lup.lub.lu.s...
Abstract
Subject headings
Close
- Neuronal death after injury or disease could result from imbalanced cytokine expression. Linomide (LS-2616, quinoline-3-carboxamide), a synthetic immunomodulator with effects on cytokine production, suppresses autoimmune diseases of the nervous system. Here adult mice were pre-treated with 200 mg/kg/day of Linomide for 9 days, after which the sciatic nerves were crushed. After another 10 days of Linomide treatment the dorsal root ganglia were dissected out and stained for apoptosis, either immediately or after 2 days in culture, which increases cell death. Superior cervical ganglia were also cultured for 2 days. The Linomide pretreatment profoundly reduced (~60- 80%) the injury-induced apoptotic death of neurons and satellite cells in both systems. The results suggest that modulation of the inflammatory cytokine cascade is a promising road to nerve cell rescue.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- Apoptosis
- Cytokines
- Immunomodulation
- Macrophages
- Nerve regeneration
- Neuronal death
- Neuronal survival
- Peripheral nerves
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database