| 1. |
- Jaderstad, Johan, et al.
(författare)
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Hypoxic preconditioning increases gap-junctional graft and host communication
- 2010
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Ingår i: NeuroReport. - 0959-4965 .- 1473-558X. ; 21:17, s. 1126-1132
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Tidskriftsartikel (refereegranskat)abstract
- Gap-junctional intercellular communication between grafted neural stem cells (NSCs) and host cells seems to be essential for many of the functional and beneficial interactions after NSC engraftment. Gap-junctional communication is also known to increase in the central nervous system after hypoxia and ischemia. We therefore hypothesized that controlled hypoxic preconditioning of murine NSCs (C17.2) before the engraftment is a reliable method to increase connexin 43 expression and improve subsequent graft and host communication. Data indicated that 3-h exposure to hypoxia increased the number of connexin 43 aggregates in treated NSCs by 31%. This was paralleled by enhanced hemichannel function showed by faster calcein dye efflux and an augmentation of the early functional graft and host communication.
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| 2. |
- Kruusmagi, Markus, et al.
(författare)
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Intracellular dynamics of calcyon, a neuron-specific vesicular protein
- 2007
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Ingår i: NeuroReport. - 0959-4965 .- 1473-558X. ; 18:15, s. 1547-1551
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Tidskriftsartikel (refereegranskat)abstract
- Calcyon is a brain-specific protein, implicated in clathrin-mediated endocytosis. In this descriptive study we show that calcyon is exclusively expressed in neurons, and localized in moving vesicles. The movement of calcyon-containing vesicles was dependent on temperature and on intact microtubules, in addition these vesicles were colocalized with a marker for endocytosed plasma membrane proteins, suggesting that calcyon vesicles follow the endocytic recycling pathway. We also show using evanescent wave microscopy that there is a pool of ready releasable calcyon vesiclesaccumulated beneath the plasma membrane. We conclude that the mobility and storage properties of calcyon-containing vesicles imply that they play a role in brain plasticity.
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| 3. |
- Thordstein, Magnus, et al.
(författare)
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Sex differences in electrocortical activity in human neonates
- 2006
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Ingår i: Neuroreport. - : Ovid Technologies (Wolters Kluwer Health). - 0959-4965 .- 1473-558X. ; 17:11, s. 1165-8
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Tidskriftsartikel (refereegranskat)abstract
- Cerebral cortical activity in healthy, full-term human neonates (10 boys and 10 girls) was evaluated using spectral estimation of electroencephalogram frequency content with new equipment and analysis technique allowing the assessment of the lowest frequencies (i.e. infraslow waves). The activity was analysed under quiet sleep and active wakefulness taking sex into consideration. During sleep, the mean amount of infraslow activity was 27% larger in boys, whereas during wakefulness the average amount of higher frequencies was 17% larger in girls. Both these differences indicate an earlier maturation of cortical function in girls than in boys.
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