| 1. |
- Boisvert, Isabelle, et al.
(author)
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Long-term monaural auditory deprivation and bilateral cochlear implants
- 2012
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In: NeuroReport. - : Lippincott, Williams and Wilkins. - 0959-4965 .- 1473-558X. ; 23:3, s. 195-199
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Journal article (peer-reviewed)abstract
- Long-term binaural auditory deprivation is associated with poorer speech recognition outcomes after cochlear implantation, even for postlingual hearing loss. It is, however, unknown to what extent the outcomes of implantation are related to the peripheral changes occurring monaurally or to changes at a higher level in the auditory system related to binaural deafness. This retrospective study aimed to unravel peripheral and central contributions to cochlear implantation outcomes by comparing outcomes obtained in individual ears for adults with long-term monaural auditory deprivation (i.e. unilateral use of hearing aid) who received bilateral cochlear implants. Results showed that similar outcomes can be obtained with the implant placed in the auditory-deprived or in the aided ear. This suggests that the peripheral changes related to monaural auditory deprivation have little effect on outcomes of cochlear implantation. NeuroReport 23: 195-199
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| 2. |
- Duan, Maoli, et al.
(author)
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Imaging of the guinea pig cochlea following round window gadolinium application
- 2004
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In: NeuroReport. - : Wolters Kluwer. - 0959-4965 .- 1473-558X. ; 15:12, s. 1927-1930
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Journal article (peer-reviewed)abstract
- Precise, non-invasive determination of the aetiology and site of pathology of inner ear disorders is difficult. The aim of this study was to describe an alternative method for inner ear visualization, based on local application of the paramagnetic contrast agent gadolinium. Using a 4.7 T MRI scanner, high contrast images of all four cochlear turns were obtained 3.5 h after placing gadolinium on the round window membrane. Gadolinium cleared from the cochlea within 96 h. Auditory brainstem response measurements performed on a separate group of animals showed no significant threshold shifts after the application, indicating that gadolinium is non-toxic to the guinea pig cochlea.
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| 3. |
- Ekman, A., et al.
(author)
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Neuromuscular block and the electroencephalogram during sevoflurane anaesthesia
- 2007
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In: NeuroReport. - 0959-4965 .- 1473-558X. ; 18:17, s. 1817-1820
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Journal article (peer-reviewed)abstract
- The effect of neuromuscular block on the anaesthetic depth of hypnosis is an elusive question. We simultaneously investigated the influence of neuromuscular block on the bispectral index, a measure of hypnosis during general anaesthesia, and on the electroencephalogram. Patients were anaesthetized with sevoflurane. Noxious tetanic electrical stimulation was applied on two occasions: before and after profound neuromuscular block achieved with rocuronium. Neuromuscular block significantly attenuated the effect from noxious stimulation on electroencephalogram power and synchrony in the γ band (P<0.05), and the corresponding effect on bispectral index (P<0.02). These findings are probably due to the reduced arousing afferent input from paralysed muscles, and not to changes in the frontal electromyogram.
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| 4. |
- Fridberger, Anders, 1966-, et al.
(author)
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Local mechanical stimulation of the hearing organ by laser irradiation
- 2006
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In: NeuroReport. - : Ovid Technologies (Wolters Kluwer Health). - 0959-4965 .- 1473-558X. ; 17:1, s. 33-37
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Journal article (peer-reviewed)abstract
- Light produces force when interacting with matter. Such radiation pressure may be used to accelerate small objects along the beam path of a laser. Here, we demonstrate that a moderately powerful laser can deliver enough force to locally stimulate the hearing organ, in the absence of conventional sound. Damped mechanical oscillations are observed following brief laser pulses, implying that the organ of Corti is locally resonant. This new method will be helpful for probing the mechanical properties of the hearing organ, which have crucial importance for the ear's ability to detect sound.
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| 5. |
- Jiang, Chonghe, 1951-, et al.
(author)
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Cooling of the urinary bladder activates neurons in the dorsal horn of the spinal cord
- 2004
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In: NeuroReport. - : Ovid Technologies (Wolters Kluwer Health). - 0959-4965 .- 1473-558X. ; 15:2, s. 351-355
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Journal article (peer-reviewed)abstract
- Although visceral innocuous cold receptors have been documented, the central termination of their afferents is unknown. We used menthol solution (0. 6 m M) to obtain selective activation of cold receptors in the urinary bladder of rats. Innocuous cold stimulation induced Fos expression in a population of neurons in the superficial dorsal horn of L6-SI segments of the spinal cord. Neurons in other regions of the spinal cord, e.g. the lumbar parasympathetic nucleus or the dorsal commissure region, were activated to a similar degree by menthol and control infusions, indicating a response to bladder filling. Our results are consistent with the proposal that subsets of modality-specific dorsal horn neurons convey specific information regarding the exteroceptive and interoceptive state of the animal. © 2004 Lippincott Williams & Wilkins.
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| 6. |
- Paues, Jakob, et al.
(author)
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Feeding-related immune responsive brain stem neurons : association with CGRP
- 2001
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In: Neuroreport. - 0959-4965 .- 1473-558X. ; 12:11, s. 2399-2403
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Journal article (peer-reviewed)abstract
- Using dual-labeling in situ hybridization histochemistry, the neurotransmitter expression of immune-responsive neurons in the pontine parabrachial nucleus, a major relay for interoceptive information, was investigated. Intravenous injection of bacterial wall lipopolysaccharide resulted in dense c-fos mRNA expression in the external lateral parabrachial nucleus, and a majority of the c-fos expressing cells also expressed calcitonin gene-related peptide (CGRP) mRNA. In contrast CGRP-posi- tive cells in the adjoining external medial subnucleus were c-fos negative. Taken together with previous hodological and behavioral studies, these data suggest that CGRPergic parabrachial neurons may mediate lipopolysaccharide-induced anorexia by means of their projection to central nucleus of the amygdala.
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