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Sökning: L773:1013 7424

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1.
  • Edvinsson, Lars, et al. (författare)
  • Neuropeptides in cerebrospinal fluid of patients with Alzheimer's disease and dementia with frontotemporal lobe degeneration
  • 1993
  • Ingår i: Dementia (Switzerland). - : Karger. - 1013-7424. ; 4:3-4, s. 71-167
  • Tidskriftsartikel (refereegranskat)abstract
    • The two major primary degenerative dementias, dementia of Alzheimer type (DAT) and frontal lobe degeneration of non-Alzheimer type (FLD) have several clinical features in common but also many symptoms that differ. In a clinical material of 80 patients with either of the two forms of dementia (DAT = 39, FLD = 41) we have studied the levels of neuropeptides in the cerebrospinal fluid (CSF) in order to find biochemical markers for CNS affection. The dementia forms were evaluated by careful clinical analysis, psychometric testing and measurement of regional cerebral blood flow. Approximately one third of the subjects died during the completion of the study and neuropathology was performed, confirming the diagnoses. We observed reductions in the CSF levels of antidiuretic hormone and somatostatin in both DAT and FLD. A strong tendency to reduction was noted for neuropeptide Y (NPY). There was a correlation with the duration of disease demonstrating a significant reduction in NPY levels in subjects with DAT. Most notably there was a strong reduction in the levels of delta sleep inducing peptide (DSIP) in DAT cases only. The levels of DSIP in FLD were the same as in controls. The reverse was found for corticotropin releasing factor (CRF) which had a significant reduction in FLD patients but not in those with DAT. The present study indicates a difference in the CSF levels of neuropeptides, observations that these may serve as biochemical markers which differentiate DAT and FLD.
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2.
  • Elfgren, C, et al. (författare)
  • Neuropsychological findings in frontal lobe dementia
  • 1993
  • Ingår i: Dementia (Switzerland). - : Karger. - 1013-7424. ; 4:3-4, s. 9-214
  • Tidskriftsartikel (refereegranskat)abstract
    • Neuropsychological investigations were performed on 18 patients with a clinical diagnosis of frontal lobe dementia supported by regional cerebral blood flow measurements. Nature and degree of cognitive impairment were examined with a comprehensive test battery. The results of the neuropsychological assessment could be described as three levels of cognitive impairment. The increasing levels of cognitive impairment were accompanied by corresponding levels of reduced cerebral blood flow in frontotemporal areas. No apparent relationship emerged between impairment level and illness duration, indicating a considerable individual variation in the clinical course of frontal lobe dementia.
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3.
  • Elmstahl, S., et al. (författare)
  • Quantitative EEG in elderly patients with Alzheimer's disease and healthy controls
  • 1994
  • Ingår i: Dementia (Switzerland). - : Karger. - 1013-7424. ; 5:2, s. 119-124
  • Tidskriftsartikel (refereegranskat)abstract
    • Multichannel (19) EEG were analyzed in 23 female patients with rather advanced late-onset Alzheimer's disease (AD) and compared with 56 age- and sex-matched healthy control subjects. The quantified EEG was correlated with psychometric and clinical variables. The control subjects showed increasing theta activity with age but the EEG changes did not correlate significantly with psychometric features. The AD patients showed highly significant increases in delta and theta activity and decreases in beta activity compared with controls. The EEG changes were most marked over posterior regions of the brain. The individual EEG variables showed a high degree of intercorrelation and an almost complete discrimination between patients and controls was accomplished by taking only the posterior delta activity into account. In a subgroup of 10 patients, in which a Mini Mental test score could be obtained, the score correlated with the relative theta power.
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4.
  • Elmståhl, S., et al. (författare)
  • Increased sweat sodium concentration in patients with Alzheimer's disease
  • 1993
  • Ingår i: Dementia (Switzerland). - : Karger. - 1013-7424. ; 4:1, s. 50-53
  • Tidskriftsartikel (refereegranskat)abstract
    • Sweat sodium concentration was estimated with pilocarpine iontophoresis in I 15 women with Alzheimer's disease (AD) and 29 healthy control women. The age ranged from 76 to 96 years with a mean age of 85 years in both groups. The mean sodium concentration of 91 ± 41 mmol/l (n = 11) in the Alzheimer patients was significantly higher than in the control group (62 ± 29 mmol/l, n=27, p=0.0011). 27% of AD patients and 7% of the control women did not respond to stimulation. The impaired sweating in AD patients make them more vulnerable to heat stress. Further studies are needed to reveal whether the neurophysiological mechanism involved is located in the hypothalamus, in cortical projections to the hypothalamus or in postganglionic sympathetic fibers.
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9.
  • Johansson, Barbro (författare)
  • Pathogenesis of vascular dementia: the possible role of hypertension
  • 1994
  • Ingår i: Dementia (Switzerland). - : Karger. - 1013-7424. ; 5:3-4, s. 174-176
  • Tidskriftsartikel (refereegranskat)abstract
    • In spite of the fact that hypertension is the main risk factor for cerebrovascular disease, retrospective studies have not given a clear answer concerning the role of hypertension in vascular dementia. Hypertension predisposes to intracerebral and extracerebral arterial alterations which may cause cerebrovascular events by a number of mechanisms. In addition to the established association between hypertension and stroke, the role of hypertension for silent white matter hyperintensities (WMHIs) observed on magnetic resonance imaging is debated. Data are presented indicating that WMHIs are rare below the age of 55 in normotensive individuals but are not infrequent when the blood pressure is moderately or markedly increased. It is proposed that the possible role of hypertension in vascular dementia should be evaluated in prospective studies of hypertensive populations.
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  • Resultat 1-10 av 18
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