SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:1055 9965 OR L773:1538 7755 ;lar1:(kth)"

Sökning: L773:1055 9965 OR L773:1538 7755 > Kungliga Tekniska Högskolan

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Yngveson, A, et al. (författare)
  • p53 Mutations in lung cancer associated with residential radon exposure.
  • 1999
  • Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 8:5
  • Tidskriftsartikel (refereegranskat)abstract
    • Unusual mutation patterns in lung tumors among underground miners have been indicated, suggesting radon-specific alterations in the genome, but the data are not consistent. To investigate the association between residential radon exposure and p53 mutations in lung tumors, we performed a study on cases from a nation-wide population-based investigation in Sweden. Our study included 83 nonsmoking lung cancer cases and 250 smoking lung cancer cases, diagnosed 1980-1984, with a time-weighted average radon exposure over 140 Bq/m3 or up to 50 Bq/m3. Radon was measured in dwellings occupied by the study subjects at some time since 1947. Information on smoking habits and other risk factors was obtained from questionnaires. After exclusions because of the initiation of treatment or insufficient material, the p53-status of 243 tumors was determined using PCR-single-stranded conformation polymorphism analysis and sequencing determination of exons 5-8. The overall mutation prevalence was 23.9%. An increased mutation prevalence was suggested among those with high exposure to residential radon [odds ratio (OR), 1.4; 95% CI, 0.7-2.6], especially among nonsmokers (OR, 3.2; 95% CI, 0.7-15.5), but no specific mutational pattern was indicated. Furthermore, the mutation prevalence seemed to be higher among smoking lung cancer cases than among nonsmoking cases (OR, 2.1; 95% CI, 0.9-5.0), and particularly among those smoking less than 10 cigarettes per day. It may be concluded that residential exposure to radon seems to contribute to a higher mutation prevalence of the p53 gene in lung tumors.
  •  
2.
  • Örtendahl, Monica, et al. (författare)
  • Somatic, psychological and social judgments related to smoking among pregnant and non-pregnant women
  • 2007
  • Ingår i: Journal of Addictive Diseases. - 1055-0887 .- 1545-0848. ; 26:4, s. 69-77
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: To examine the association between pregnancy and judgments about a range of somatic, psychological and social events and conditions related to smoking. Basic Procedures: Pregnant and non-pregnant women smokers, intending and not intending to quit, were contacted in family practices in Bulgaria where they were under ordinary medical observation. All 80 women in the study were asked to rate consequences related to smoking in terms of how good or bad they were. Results: Being pregnant or not pregnant had the main effect on rated values of smoking-related consequences, with non-pregnant women giving the least positive ratings across the time-span of the study and whether or not they intended to quit. No statistically significant difference was obtained between the quitting and non-quitting women, and there was only one statistically significant difference for different days. Conclusions: The physical variable of pregnancy has a larger impact on judgments about smoking compared to the motivational aspect of intending to quit.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy