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Sökning: L773:1382 5585 OR L773:1744 4128 > Karolinska Institutet

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  • de Frias, Cindy, et al. (författare)
  • Sex differences in cognition are stable over a 10-year period in adulthood and old age.
  • 2006
  • Ingår i: Aging, Neuropsychology and Cognition. - : Informa UK Limited. - 1382-5585 .- 1744-4128. ; 13:3-4, s. 574-587
  • Tidskriftsartikel (refereegranskat)abstract
    • Sex differences in declarative memory and visuospacial ability are robust in cross-sectional studies. The present longitudinal study examined whether sex differences in cognition were present over a 10-year period, and whether age modified the magnitude of sex differences. Tests assessing episodic and semantic memory, and visuospatial ability were administered to 625 nondemented adults (initially aged 35-80 years), participating in the population based Betula study at two follow-up occasions. There was stability of sex differences across five age groups and over a 10-year period. Women performed at a higher level than men on episodic recall, face and verbal recognition, and semantic fluency, whereas men performed better than women on a task assessing visuospatial ability. Sex differences in cognitive functions are stable over a 10-year period and from 35 to 90 years of age. Decreasing levels of estrogen in women and sex differences in age-related cortical atrophy do not seem to influence cognitive sex differences.
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  • Derwinger, Anna, et al. (författare)
  • Remembering Numbers in Old Age : Mnemonic Training Versus Self-Generated Strategy Training
  • 2003
  • Ingår i: Aging, Neuropsychology and Cognition. - : Routledge. - 1382-5585 .- 1744-4128. ; 10:3, s. 202-214
  • Tidskriftsartikel (refereegranskat)abstract
    • The effectiveness of two memory training programs designed to enhance four-digit number recall was examined in 90 healthy older adults. One group received instruction and training in the number-consonant mnemonic, whereas another group was instructed to adopt their own encoding and retrieval strategies to enhance number recall. Also, a control group receiving no training between testing occasions was included. The criterion task was administered according to the Buschke selective reminding procedure. Posttest performance was evaluated with and without cognitive support for remembering (i.e., verbal cues). Under unsupported conditions, the mnemonic group improved number recall following training and the selfgenerated strategy group showed a tendency in the same direction. When support was provided, group differences in favor of the two training groups increased. In addition, no training-related gains were observed in two verbal transfer tasks. The relatively similar patterns of gains in the two intervention groups were discussed in terms of advantages and disadvantages in the two training regimens balancing each other.
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  • Fernaeus, Sven-Erik, et al. (författare)
  • Conceptual elaboration versus direct lexical access in WAIS-similarities : differential effects of white-matter lesions and gray matter volumes
  • 2018
  • Ingår i: Aging, Neuropsychology and Cognition. - : Informa UK Limited. - 1382-5585 .- 1744-4128. ; 25:6, s. 893-903
  • Tidskriftsartikel (refereegranskat)abstract
    • Wechsler Adult Intelligence Scale (WAIS) subscale Similarities have been classified as a test of either verbal comprehension or of inductive reasoning. The reason may be that items divide into two categories. We tested the hypothesis of heterogeneity of items in WAIS-Similarities. Consecutive patients at a memory clinic and healthy controls participated in the study. White-matter hyperintensities (WMHs) and normalized temporal lobe volumes were measured based on Magnetic resonance Imaging (MRI), and tests of verbal memory and attention were used in addition to WAIS-Similarities to collect behavioural data. Factor analysis supported the hypothesis that two factors are involved in the performance of WAIS-similarities: (1) semiautomatic lexical access and (2) conceptual elaboration. These factors were highly correlated but provided discriminative diagnostic information: In logistic regression analyses, scores of the lexical access factor and of the conceptual elaboration factor discriminated patients with mild cognitive impairment from Alzheimer’s disease patients and from healthy controls, respectively. High scores of WMH, indicating periventricular white-matter lesions, predicted factor scores of direct lexical access but not those of conceptual elaboration, which were predicted only by medial and lateral temporal lobe volumes.
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  • Hassing, L, et al. (författare)
  • Mortality-related differences and changes in episodic memory among the oldest old : evidence from a population-based sample of nonagenarians
  • 2002
  • Ingår i: Aging, Neuropsychology and Cognition. - : Taylor & Francis. - 1382-5585 .- 1744-4128. ; 9:1, s. 11-20
  • Tidskriftsartikel (refereegranskat)abstract
    • We examined cross-sectional differences and longitudinal changes in episodic memory performance related to impending death among a group of very old people, aged 90–101 years. Participants were assessed at 3 measurement points across a 6-year interval. Three groups were identified: those who survived the entire follow-up period (n =40), those who died before the first follow-up (n =44), and those who died after the first follow-up (n =14). Participants completed a battery of episodic memory tasks consisting of face recognition, word recognition, word recall, and object recall with selective reminding. Those who survived performed better than those who were going to die in object recall at baseline. A Cox regression analysis, controlling age, revealed that object recall performance was significantly related to subsequent mortality status. Longitudinal analyses demonstrated significant 3-year decline for both face recognition and object recall, but no evidence of differential decline as a function of mortality group. Thus, longitudinal changes in memory preceding death were not as pronounced as the corresponding cross-sectional differences in this very old sample. In general, the results suggest that mortality-related memory deficits are present in extreme old age, although these deficits are relatively small and task-specific.
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