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Träfflista för sökning "L773:1424 8247 OR L773:1424 8247 ;pers:(Langel Ülo)"

Sökning: L773:1424 8247 OR L773:1424 8247 > Langel Ülo

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1.
  • Regberg, Jakob, et al. (författare)
  • Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies
  • 2012
  • Ingår i: Pharmaceuticals. - : MDPI AG. - 1424-8247. ; 5:9, s. 991-1007
  • Tidskriftsartikel (refereegranskat)abstract
    • Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the treatment, either of conventional small molecular drugs or oligonucleotide based therapeutics. This review is focused on the cancer applications of cell penetrating peptides as delivery systems; different aspects of drug loading, cargoes and delivery are discussed together with methods for targeted delivery, activatable cell-penetrating peptides and transducible agents coupled to cell-penetrating peptides.
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2.
  • Saar, Külliki, et al. (författare)
  • Distribution of CPP-protein complexes in freshly resected human tissue material
  • 2010
  • Ingår i: Pharmaceuticals. - : MDPI AG. - 1424-8247. ; 3:3, s. 621-635
  • Tidskriftsartikel (refereegranskat)abstract
    • Interest in cell-penetrating peptides (CPPs) as delivery agents has fuelled a large number of studies conducted on cultured cells and in mice. However, only a few studies have been devoted to the behaviour of CPPs in human tissues. Therefore, we performed ex vivo tissue-dipping experiments where we studied the distribution of CPP-protein complexes in samples of freshly harvested human tissue material. We used the carcinomaor hyperplasia-containing specimens of the uterus and the cervix, obtained as surgical waste from nine hysterectomies. Our aim was to evaluate the tissue of preference (epithelial versus muscular/connective tissue, carcinoma versus adjacent histologicallynormal tissue) for two well-studied CPPs, the transportan and the TAT-peptide. We complexed biotinylated CPPs with avidin-β-galactosidase (ABG), which enabled us to apply whole-mount X-gal staining as a robust detection method. Our results demonstratethat both peptides enhanced the tissue distribution of ABG. The enhancing effect of the tested CPPs was more obvious in the normal tissue and in some specimens we detected a striking selectivity of CPP-ABG complexes for the normal tissue. This unexpected finding encourages the evaluation of CPPs as local delivery agents in non-malignant situations, for example in the intrauterine gene therapy of benign gynaecological diseases.
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refereegranskat (2)
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Langel, Ülo (2)Ta bort avgränsningen
Regberg, Jakob (1)
Hansen, Mats (1)
Pooga, Margus (1)
Saar, Külliki (1)
Srimanee, Artita (1)
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