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Träfflista för sökning "L773:1471 2466 ;pers:(Egesten Arne)"

Search: L773:1471 2466 > Egesten Arne

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  • Hovold, Gisela, et al. (author)
  • Heparin-binding protein in sputum as a marker of pulmonary inflammation, lung function, and bacterial load in children with cystic fibrosis
  • 2018
  • In: BMC Pulmonary Medicine. - : Springer Science and Business Media LLC. - 1471-2466. ; 18:1
  • Journal article (peer-reviewed)abstract
    • Background: Cystic fibros.000000 bacterial pulmonary infections and neutrophil-dominated inflammation in the airways. The aim of this study was to evaluate the neutrophil-derived protein Heparin-binding protein (HBP) as a potential sputum marker of airway inflammation and bacterial load. Methods: Nineteen CF patients, aged 6-18 years, were prospectively followed for 6 months with sputum sampling at every visit to the CF clinic. A total of 41 sputum samples were collected. Sputum-HBP was analysed with ELISA, neutrophil elastase activity with a chromogenic assay, and total bacterial load with RT-PCR of the 16 s rDNA gene. Data were compared to lung function parameters and airway symptoms. Results: HBP and elastase correlated to a decrease in FEV1%predicted compared to the patients' individual baseline pulmonary function (ΔFEV1), but not to bacterial load. Area under the receiver operating characteristic curve values for the detection of > 10% decrease in ΔFEV1 were 0.80 for HBP, 0.78 for elastase, and 0.54 for bacterial load. Conclusions: Sputum HBP is a promising marker of airway inflammation and pulmonary function in children with CF.
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2.
  • Påhlman, Lisa, et al. (author)
  • Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1.
  • 2015
  • In: BMC Pulmonary Medicine. - : Springer Science and Business Media LLC. - 1471-2466. ; 15:1
  • Journal article (peer-reviewed)abstract
    • Secretory leukocyte protease inhibitor (SLPI) is a protein with anti-protease and antimicrobial properties that is constitutively secreted from the airway epithelium. The importance of maintaining a balance between proteases and anti-proteases, and robust innate defence mechanisms in the airways, is exemplified by inflammatory lung conditions such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). Both conditions present with a high protease burden in the airways which leads to tissue destruction. These patients also have an impaired innate immune system in the lungs with bacterial colonization and frequent airway infections. Moreover, both diseases are associated with airway hypoxia due to inflammation and mucus plugs. The aim of the present study was to investigate the role of hypoxia on SLPI production from the airway epithelium.
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Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Egesten, Arne (2)Undo refine
Gram, Magnus (1)
Mori, Michiko (1)
Jögi, Annika (1)
Påhlman, Lisa I. (1)
Kahn, Fredrik (1)
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Påhlman, Lisa (1)
Hovold, Gisela (1)
Palmcrantz, Victoria (1)
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University
Lund University (2)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)

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