Search: L773:1474 4465 OR L773:1474 4422
> (2005-2009)
> Kokaia Zaal >
Emerging concepts i...
Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling
-
Koch, Philipp (author)
-
- Kokaia, Zaal (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Wallenberg Neurocentrum, Lund,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Wallenberg Neuroscience Centre, Lund
-
- Lindvall, Olle (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Wallenberg Neurocentrum, Lund,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Wallenberg Neuroscience Centre, Lund
-
show more...
-
Bruestle, Oliver (author)
-
show less...
-
(creator_code:org_t)
- 2009
- 2009
- English.
-
In: Lancet Neurology. - 1474-4465. ; 8:9, s. 819-829
- Related links:
-
https://lup.lub.lu.s...
Abstract
Subject headings
Close
- The increasing availability of human pluripotent stem cells provides new prospects for neural-replacement strategies and disease-related basic research. With almost unlimited potential for self-renewal, the use of human embryonic stem cells (ESCs) bypasses the restricted supply and expandability of primary cells that has been a major bottleneck in previous neural transplantation approaches. Translation of developmental patterning and cell-type specification techniques to human ESC cultures enables in vitro generation of various neuronal and glial cell types. The derivation of stably proliferating neural stem cells from human ESCs further facilitates standardisation and circumvents the problem of batch-to-batch variations commonly encountered in "run-through" protocols, which promote terminal differentiation of pluripotent stem cells into somatic cell types without defined intermediate precursor stages. The advent of cell reprogramming offers an opportunity to translate these advances to induced pluripotent stem cells, thereby enabling the generation of neurons and glia from individual patients. Eventually, reprogramming could provide a supply of autologous neural cells for transplantation, and could lead to the establishment of cellular model systems of neurological diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- for (subject category)
- ref (subject category)
Find in a library
To the university's database